“highly significant”

However, gene ontology enrichment analysis revealed a highly significant enrichment of glycolysis-associated proteins ( P < 10 10 ), with downregulation of the entire glycolytic pathway, and conversely an upregulation of AMP-activated protein kinase signaling– and autophagy-associated proteins, promoting catabolic pathways to generate more ATP.

The overall statistic is highly significant ( p < 10 −10 ) for the first three eigenvectors but insignificant for the fourth ( p = 0.97), indicating that this eigenvector is capturing population subdivision that is different from the traditional western/central/eastern/bonobo designations.

For each of the module, we have assigned the clinical annotation, when it is highly significant (p < 10 −10 ) and when the minimum hit of the module genes on cancer pathways is atleast 50%.

5 , 6 , p < 0.05, false discovery rate (FDR) corrected], and in nine such comparisons, results were highly significant (Figs. 5 , 6 , p < 10 −10 , FDR corrected); see Supplementary Data 5 for AUC histogram bin data (bootstrapped resamples).

In both cases the difference is highly significant ( P << 10 −10 ).

5C ), and this difference was highly significant within an animal across within-sequence repetitions (Fig. 5D , p < 10 −10 , Wilcoxon Rank Sum test, n 1 = 162, n 2 = 1428) and across animals (Fig. 5E , p = 0.0079, Wilcoxon Rank Sum test, n = 5), as well as in single cells recorded in the ORR in 2p in the same animals (Fig. 5F , p < 10 −100 , Wilcoxon Rank Sum test, n = 765).

The first four inferred edges are highly significant (p<10 −10 for m = 1 to m = 4), the last one however to a much lesser extent (p = 0.009).

In these studies, a highly significant ( P <1×10 −10 ) association was detected for CDKAL1 , in accordance with the present study in Japanese.

Compared to the expectation under random assignment, this is an over-representation in this category of 40% in yeast and 29% in human, which is modest, but because of the large numbers, highly significant (both p<1e-10).

Indeed, we observed a highly significant enrichment of H3K9 methylation at 49 known 26G loci ( Vasale et al. 2010 ) compared to 100 random genes ( P -value < 1 × 10 −10 ) ( Fig. 5C ).

On the basis of counting statistics (binomial distribution), this difference is highly significant ( p << 10 −10 ).

Emmetropization There was strong evidence of emmetropization (Figures 4(a) and 4(b) ) in RAR and ROP Sprague-Dawley rats ( dashed light blue and light red lines ) as well as ROP Long-Evans rats ( dark red lines ) resulting in a highly significant effect of age ( F (age) = 32.6, df = 2,78, P < 10 −10 ).

On applying a relaxed threshold of FDR <0.3 we observed a total of 2,514 BRCA1 -mutation associated CpGs, of which 1,422 (57%) were hypermethylated (hyperM) and 1,092 (43%) were hypomethylated (hypoM) in women who had a BRCA1 mutation (Figure 1 , Additional file 5 ), representing a highly significant skew towards hypermethylated CpGs (Binomial test P < 1e-10).

The Pearson correlation coefficients for branching density and asymmetry index ( R = −0.50) and for bifurcation amplitude remote and asymmetry ( R = 0.51) are both statistically highly significant ( p < 10 −10 ).

The difference between the fraction of paused and non-paused genes containing GrIn1 elements was highly significant (χ 2 = 82; P < 10 −10 ).

A P -value of 0.007 was achieved when testing the difference between carbonate content between low-grade DCIS and ICs G1, whereas the statistical difference between moderate-grade DCIS and IC G2 and high-grade DCIS and IC G3 were once again highly significant with P -values <10 −10 .

This revealed four regions with highly significant differentiation ( P < 10 −10 after Bonferroni correction, per SNP χ 2 test (d.f. = 1); Supplementary Fig. 1 ).

This difference is highly significant statistically (P < 1.0E-10, Chi-square test).

Numbers in bold indicate highly significant partial correlations ( P < 1 e - 10).

The logistic regression and Cox models adjusted for tumour size were also consistent with a highly significant difference between the two groups ( P <10 −10 ).

This number is more than 100 times greater than expected by chance, a difference that is statistically highly significant ( p < 10 −10 , sign test).

This is highly significant ( p -value < 10 −10 ) at or beyond the α = 0.05 level.

Across multiple Glomeromycetes species, chi-square tests of double-base substitution bias gave highly significant P value (all p < 10 − 10 ), and TT>AA, TA>AT, and AT>TA repeatedly showed the strongest positive standardized residuals within the TT, TA, and AT categories, respectively ( Supplementary Tables S4 , available as supplementary material at Bioinformatics Advances online; Supplementary Methods , secti

This was largely due to a few eeQTLs with relatively highly significant effects ( p < 1e-10) on the expression levels of the 2nd exon in the milk cells and a similar but less significant effect ( p < 1e-4) on the 2nd exon expression in white blood cells (Additional file 2 : Figure S7).

We found 1060 upregulated genes in Wit49 and 396 in 17.94, with a highly significant overlap of 212 genes between the two cell-lines ( p < 10 −10 ) ( Figure 3 A).