“highly significant”

For the delta-ADP test, we performed the Kaplan–Meier analysis for bleeding events during the follow-up of 180 days, using the Youden index of our delta-ADP ROC curve as cut-off, and showed this to be highly significant ( p = 0.004; Fig. 7 ).

The heterogeneity between all prospective and retrospective studies was highly significant ( P = 0.004).

A permutation test further verified that the actual difference in standard deviations between late versus early start groups is highly significant relative to what this standard deviation difference would be under random group labeling (p = 0.004) ( Fig. 1D ).

The results revealed a highly significant main effect of relatedness, F (1, 29) = 9.50, MSE = 32, 294, p = 0.004, showing that response latencies were faster in the related condition than in the unrelated condition.

We tested drug-drug interactions for three pairs: KP372-1 + rucaparib, KP372-1 + olaparib, and KP372-1 + talazoparib, all of which showed highly significant effect of synergy (η = 0.472, P = 0.004; η = 0.453, P = 0.002; η = 0.613, P = 0.009, respectively).

Using this cut-off value, a highly significant prognostic role for CD8 on RFS was observed (Figure 2 , log-rank test, p = 0.004, cohort 2).

Post-hoc comparisons revealed that this significantly decrease by day 35 (P = 0.01 compared to day 0) and was highly significant by day 70 (P = 0.004 compared to day 0).

We also observed a highly significant increase in the frequency of NK cells labeled with 2F1 antibody ( P = 0.004), which recognizes the maturation marker KLRG1, in BALB- Cmv3 MA/My H2 d mice compared to their H2 k counterparts.

The prediected linear regression was highly significant (R 2 =0.345, r =0.59, P=0.004).

Importantly, however, the main effect of Mimicry Type remained highly significant when the effect of Gender and the interaction of Gender and Mimicry Type were controlled (Wald χ 2 (2) = 11.21, p = 0.004).

The PCT improvement was highly significant in the aggregated analysis (p = .004).

The difference in age at onset of EM disease between the three groups of patients was highly significant (P < 0.004; Fig. 3 d).

Since our main goal was to test the background similarity hypothesis, we pooled the same-background conditions (V–V and Λ–Λ) and pooled the orthogonal background conditions (Λ–V and V–Λ) without excluding any subject, and found that the difference between the two pooled data sets was highly significant ( p = 0.0040, t = 3.62, df = 11). 3.3.

This difference was highly significant ( P = 0.004).

The statistical analysis of the LC-MS measurements shows a highly significant increase (p = 0.004) of the [2,3- 13 C 2 ]lactate-to-[2,3- 13 C 2 ]pyruvate ratio upon activation, with a 95% confidence interval of [4.54, 28.76] (Fig. 3F ).

As a further check that the interaction of Group with O-Span was not an artefact of ‘regressing out’ age effects within the older group which correlated with WMC, we also ran the model without age as a predictor, and the interaction of Group with O-Span remained highly significant (β = .47, t (33) = 3.14, p = .004; for model, R 2 = .32, F (3,31) = 4.84, MSE = 14.2, p = .007).

Presence of hyposalivation based on unstimulated salivary flow rate (IUS), although highly significant in the simple logistic regression model (OR: 2.02, 95% CI: 1.24–3.27, p-value = 0.004) was only of borderline significance when adjusted for confounders (OR: 1.68, 95% CI: 1.01–2.79, p-value = 0.046).

Of more concern is the highly significant difference in the baseline value among the groups ( p = 0.004), which was not statistically accounted for.

This is a highly significant enrichment (Fisher's exact test p-value <0.004), demonstrating that many of the genes affected by the Usf1 polymorphism might in fact be direct Usf1 targets.

The difference of CXCL10 median plasma concentration among T1R and their matched controls was highly significant (p = 0.004) (Fig 1A ).

Extent of depletion was not correlated with the magnitude of the SCR difference score in the acquisition phase ( r (27) = 0.210, p = 0.294); however, there was a highly significant correlation between greater depletion and a more pronounced reversal learning deficit ( r (27) = −0.536, p = 0.004), depicted in Fig. 5 .

The difference between Sema4D expressions regarding the response to therapy was highly significant ( p -value < 0.004) (Fig. 3 ).

Furthermore, the Kruskal–Wallis test demonstrated a highly significant difference in the median number of inhibited phytopathogens across the three proxy score groups (H = 11.04, p = 0.004, Figure S1, Supplementary Materials ).

As such, there was a highly significant additive effect of Tween ( F (2) = 279.64, p = 0.004).

Highly significant reduction in HDRS (p = 0.004) and CGI-BP (p < 0.0001) from baseline to endpoint were also noted.