“highly significant”

Overall, the difference between the HOsm and all other groups was highly significant ( P = 0.004, Figure 5 ).

A highly significant ( p = 0.004) PCT concentration demonstrated it to be a clinically meaningful effect size and a reliable biomarker in discriminating the progression of TBI post 72 h, with an AUC of 0.834 at 72 h and 0.607 at 24 h from the admission time.

The effect of treatment on SOD activities was highly significant ( P = 0.004 ), and post-hoc analyses revealed that SOD levels in the GH group were statistically lower than those of in C and G.

Tb.N, a trabecular bone morphometry parameter with the highest value, was highly significant (OR = 19,062.087, 95% CI: 22.233–16,343,266.88, p = 0.004), indicating a detrimental micro-architectural shift attributable to significant trabecular thinning despite no significant change in BV/TV.

Highly significant reduction in HDRS (p = 0.004) and CGI-BP (p < 0.0001) from baseline to endpoint were also noted.

The differences in overall promoter hypermethylation between untreated tumors (P/M1; 32%) and C1 tumors (75%) were highly significant (P = 0.004), while the differences between untreated tumors and C2/C3 tumors (62.5%) were less pronounced (P = 0.09).

Analysis of similarities (ANOSIM) analysis illustrated that the J.0 M group had significantly lower R values than the GH.3 M, GH.6 M, and GH.12 M groups ( R =0.453 696, R =0.356 417, and R =0.717 596, respectively; all P =0.004 975), and there was a highly significant difference between GH.3 M and GH.6 M ( R =0.498 653, P =0.004 975), so the GH.3 M and Z.3 M groups had higher R than the other groups and resembled the apex of the parabola, while the J.0 M, GH.12 M, and Z.‍12 M groups presented the two ends of the parabola ( Fig. 4 d).

A highly significant ( P = 0.004; 0.006, P < 0.01) difference in temperature was observed between healthy and diseased legs at both measurement points.

However, on day 6 the infectivity of the oseltamivir-treated infected group was 123-fold higher than the control infected group (10 5.4 ffu per ferret), a highly significant difference ( p = 0.004; Fig. 4 d).

This finding was highly significant for ADP response measured using platelet aggregometry (fentanyl 40.6% [ ± 19.2] vs. no-fentanyl 25.2% [ ± 10.8], p = 0.004).

Post-hoc comparisons revealed that this significantly decrease by day 35 (P = 0.01 compared to day 0) and was highly significant by day 70 (P = 0.004 compared to day 0).

The statistical analysis of the LC-MS measurements shows a highly significant increase (p = 0.004) of the [2,3- 13 C 2 ]lactate-to-[2,3- 13 C 2 ]pyruvate ratio upon activation, with a 95% confidence interval of [4.54, 28.76] (Fig. 3F ).

MLT was highly significant in the KM, PKRM, and LKRM scenarios ( p ≤ 0.004), marginally significant in the IKRM scenario ( p = 0.049), and not-significant in the RM scenario ( p = 0.055).

There was a highly significant difference between the scores of children with autism and typically developing children on the explicit unexpected location task (P=0.004).

Furthermore, a highly significant ANOSIM analysis result, with R = 0.92 and p = 0.004 shown in Figure 2e , confirmed the potential biological relevance of virome changes in OP.

This relationship was highly significant, especially after adjustment: each 10-ng increase in c- PAH levels in the Teplice district resulted in an increase of AORs by 1.22 (CI, 1.07-1.39, p < 0.004; Table 3); a similar, but nonsignifi- cant increase was found for Prachatice (1.17, CI, 0.92-1.89).

When this correlation was controlled for familiarity, it became highly significant ( N = 7, r = −0.951, P = 0.004).

These findings indicated a highly significant association between the responses of participants related to knowledge of these four issues and AAS use ( χ 2 = 11.31, P = 0.004; χ 2 = 15.51, P = 0.001; χ 2 = 16.93, P = 0.001 and χ 2 = 17.08, P = 0.001).

The highly significant p values (e.g., p = 0.004 for GRBAS G) can be attributed to the consistency of changes across patients and the large effect sizes (e.g., r = 0.70 for GRBAS G).

Presence of both DM and HTN also had a highly significant impact on arteriolar hyalinosis (p=004), GS (p=0.03) and IF/TA (p=0.001).

PERMANOVA confirmed highly significant effects of forest type on the litter (R 2 = 0.259, p = 0.004), soil (R 2 = 0.427, p = 0.001), microbial biomass (R 2 = 0.420, p = 0.001), and enzyme modules (R 2 = 0.198, p = 0.012).

Both outcomes are highly significant compared to matched historical controls (p = 0.004).

After combining the two transect probabilities by Fisher's method, overall genetic isolation by temporal distance was highly significant ( P = 0.004).

There was a highly significant negative correlation between HPT and CPT ( r = −.66; p = .004).

Differences were highly significant (p = 0.004).