“highly significant”

The main statistical analysis showed a highly significant improvement in all experimental group members during the course of treatment as evident from the objective (Wolf Motor Function Test WMFT [ 16 ]: p = 0.009; Frenchay Arm Test FAT [ 17 ]: p = 0.007; Wilcoxon-Rank-Sum-Test) and the subjective (Stroke Impairment Scale SIS [ 18 ]: p = 0.013) scales.

Following TARGIT-IORT there was an increase of 0.203 foci per cell (range −1.436 to 1.275) compared with 0.935 foci per cell (range −0.679 to 2.216) in the EBRT group; this difference was highly significant (p = 0.009).

The maximum benefit in the CROSS-trial was observed in squamous cell carcinoma, with highly significant (HR = 0.48; 95%C.I. 0.28–0.83; P = 0.009) benefit compared with surgery alone, in comparison with adenocarcinoma, where the benefit was more modest (HR = 0.73; 95%C.I.0.55–0.98; P = 0.037), but the benefit of neoadjuvant chemoradiotherapy was consistent across subgroups, without any significant interaction identified [ 1 , 2 ].

When we compared it with the rate of the control group, the difference was found to be highly significant (90% vs. 63%, p < 0.009).

We found a highly significant, negative association between log 10 cortisol/DHEA-S ratio and log 10 sCD14 (r = 0.561, p = 0.009).

The HR for BNP in Q4 was 2.32 (95% CI, 1.24-4.35) as compared to Q1, which was statistically highly significant, p = 0.009.

Moreover, analysis of patients with and without impaired RV–PA coupling as indicated by a TAPSE/sPAP ratio <0.31 mm/mmHg, revealed a highly significant difference in all‐cause mortality ( p = 0.009; Figure 3D ).

Indeed, analysis of large randomized statin trials demonstrate a highly significant ( p = 0.009) inverse association between achieved low-density lipoprotein cholesterol levels and cancer 7 .

major total extract at a concentration of 0.5 g/mL and indicates that there are highly significant differences (p=0.009).

In contrast, the study revealed a highly significant difference when comparing the influence of SPC on EOL SACT solely within the patient cohort that received SACT ( P = 0.009).

The genetic correlation was large, highly significant and strongly negative in women ( r G = −0.877, P = 0.009) in a model without covariates, but not in men ( P = 0.777).

We demonstrate a dose-dependent effect on hRECs by increasing exposure to 1, 5, and 10 mM caffeine citrate, resulting on average in highly significant CBF excitation of 14.2% ( n = 7; p = 0.009), 18.6% ( n = 6; p = 0.023), and 28.8%( n = 6; p = 0.014) over CBF b respectively (Fig. 1 d).

This finding was statistically highly significant ( p = 0.009).

HCM patients showed highly significant LV wall thickening (LVT) compared to the healthy subjects (LVT HCM = 14.94 ± 2.98 mm; LVT Healthy = 11.77 ± 1.27 mm; P = 0.009) ( Figure 1B ).

The analysis showed that the between-groups treatment effect on ADOS scores continued all through this time (OR −8.2; −1.53, −0.12, p = 0.02), giving a highly significant cumulative effect of the therapy [marginal log-odds effect size of 0.55 (95% CI 0.14–0.91; p = 0.009)] ( 29 ; see Figure 1 ).

But, a highly significant decrease in the intensity of mental pain was detected [M 0 = 4.3 ± 3.06, M 1 = 3.1 ± 2.36, M 2 = 2.7 ± 2.64: F (2, 38) = 5.4, p = 0.009; partial η 2 = 0.22; Cohen's f = 0.53].

Though the mortality difference was highly significant (absolute risk reduction of 30% for hospital mortality, p = 0.009, NNT = 3.3), only one or two deaths in the hydrocortisone group would have been sufficient to tip the balance toward a non-significant mortality difference and in favor of study continuation, rather than early termination of the trial.

The difference over time to develop each stage of the phenotype was highly significant between the two populations (St2: p = 0.009; St3: p < 0.0001, St4: p = 0.0033).

There was a highly significant group difference of the daily weight gain during the first 3 weeks of life (p = 0.009): HALO treated calves had a significantly lower average daily gain (ADG) than SCFP fed (p = 0.029) and CON calves (p = 0.031).

A modest (~25%), but highly significant increase in secretion (p ≤ 0.009) was observed in WDR1 knock down cells (Fig. 7E ).

In the sibling-paired analysis, the decrease in total motor score was highly significant, p = 0.009, driven by a decrease in fine motor score, p = 0.008.

In accordance with the in vivo advantage of utilizing an IL-2-independent pathway of costimulation of tumor-specific T cells, in a retrospectively analyzed cohort of patients with metastatic malignant melanoma treated with cyclophosphamide and tumor-antigen transfected DCs ( NCT00978913 ) we observed a highly significant inverse relation between overall survival and expression of IL-2Rα on DC vaccine products (p = 0.009).

In particular, in STHS (rams), the effects of the 3 ′ UTR-17 bp on the chest depth was highly significant ( P = 0.009 ). 4 Discussion Studies of SIRT genes tend to focus on the regulation of the physiological processes of cell stress responses, proliferation, apoptosis, aging, metabolism, and especially on the development of tumors (Li and Kazgan, 2011; Roth and Chen, 2014; O'Callaghan and Vassilopoulos., 2017; Ye et al., 2017).

At baseline and 2 weeks, there were no significant differences between DTSQs total scores in the three study arms ( P = 0.283 and P = 0.789) or between the two intervention arms ( P = 0.602 and P = 0.964), but at 16 weeks, the differences were highly significant ( P = 0.009 and P = 0.002).

From the analysis by Pearson’s Chi-square test, we found a highly significant difference between the two groups regarding the following parameters: - SBP ≥ 160 mmHg: p = 0.009 ( Table 3 ). - Perioperative use of clevidipine: p < 0.00001 ( Table 4 ). - Transfer to intensive care unit: p < 0.00001 ( Table 5 ).