Further analysis of the gene set revealed a highly significant enrichment (p= 1.0 −7 ) for the upstream regulator hepatocyte nuclear factor 4 alpha (HNF4α), which regulates almost 200 genes (~ 15% of genes) in the list of differentially expressed genes between the two groups post-treatment ( Supplementary Table 1B ).
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The rate ratio is highly significant at P < 0.0000001.
There was approximately a two-fold down regulation of EGFR in A + AD compared with A − AD which was highly significant (p < 10 −7 ) ( Supplementary Figure 6 ).
From duplicate measurements for each of three independent DNA preparations per construct, we again saw no effect of shRNA targeting Zfp423 , but a highly significant decrease on overexpression of human ZNF423 (p<10 −7 , Tukey HSD pair-wise test after one-factor ANOVA).
Additionally, a highly significant difference was observed in the β-cell function across the Chinese diabetic stages ( p < 0.0000001).
For the three factors where a correct association is predicted, the result is judged highly significant by a one-tailed Fisher's; Exact test ( P < 10 − 7 ) (data not shown).
The Kruskal-Wallis rank sum test revealed a highly significant effect of feedback on rating (p<10 −7 ).
P i signal dropped faster than PCr increased during recovery (see Table 1 ); the correlation between the time constants τ PCr recovery and was highly significant ( r = 0.98, p < 10 − 7 ).
Selection treatment had no significant effect on the total number of fixed mutations (electronic supplementary material, appendix B figure S14A; ANOVA p = 0.788), but the effect of the ancestor was highly significant (electronic supplementary material, appendix B figure S14B; ANOVA p < 1 × 10 −7 ).
The difference of this value with the plateau of neutralizing activity of hospitalized individuals was highly significant (p < 10 –7 by Z-test, and p < 10 –4 by Wilcoxon test as described in methods; Fig. 2 B), and reflects the different distribution (p = 0.0003, Chi-square test) of individuals with undetectable (< 20), low (20–100), medium (100–1000) or high (> 1000) neutralization titers in the non-hospitalized and the hospitalized groups (Fig. 2 C).
These changes could reflect changes in the training of those who name species, as more species are named by scientists who are not classically trained taxonomists or who have less familiarity with Latin and Greek; however, these hypotheses would be difficult to test. A notable feature of the etymological patterns in table 2 is that they vary among the surveyed taxa (and this variation is highly significant: p < 10 −7 ).
We found very strong evidence of association of multiple SNPs at TTC12 and ANKK1 in two different populations, EAs and AAs (minimal P=0.0007 in AAs and minimal P=0.00009 in EAs), and highly significant association of a single haplotype (set of markers) spanning TTC12 and ANKK1 to ND in the pooled sample (P=0. 0000001).
Combinations that we predicted to be anti-selective were indeed so, and this was highly significant when compared to the non-selective control combinations (Wilcoxon signed-rank test p < 10 − 7 , Figure 5 D).
flexneri was very highly significant ( P < 0.0000001), but survival of alone-cultivated A. castellanii compared to that of cocultivated with plasmid-cured S. flexneri was not statistically significant ( P = 0.88).
A highly significant correlation existed between the AUC values of APC and NPC ( r =0.857, P <10 −7 ).
A 2-way ANOVA on proportion of correct recalls revealed no main effect of group (F(1,34) = 3.51, p = .065, r = .25), but a highly significant effect of type of Encoding (F(1,34) = 44.45, p<.0000001, r = .75), and a significant interaction between Group and type of Encoding (F(1,34) = 9.14, p<.005, r = .46).
Ethnic Affiliation Related Pattern distributions differences in the various ethnic groups, which returned highly significant differences between the groups at the 5% level (χ 2 , p<0.0000001), have revealed that the Nilo-Saharan Berta manifested significantly higher Arch frequencies (18.68%), which is high both with respect to the other studied local ethnic groups (having arch frequencies less than 7%), as well as relative to other studied populations worldwide [ 3 , 4 ].
Of the 45 pairwise differences between the modules, 32 were significant ( p < 0.05, of which 24 were highly significant, p < 1.00 × 10 − 7 ) and 13 were not ( p > 0.05).
Pearson correlations revealed low, but highly significant, positive correlations between DRF and DTD for the entire sample ( r 28888 = 0.282; p < 0.0000001) and for males ( r 5884 = 0.276; p < 0.0000001) and females ( r 23004 = 0.287; p < 0.0000001) considered separately.
The final model (Predation = −66.2917 + 2.15625G − 0.8421X + 0.0106X 2 ) was highly significant (F 3,47 = 323.8478, p = 1 × 10 −7 ) and explained a large proportion of variation in predation (adjusted R 2 = 0.9537).
The coefficient for study arm was −12 (SEM 4.1), and the inclusion of study arm to the model was highly significant ( P = 10 −7 ), demonstrating a strong influence of the intervention on salt intake.
The difference between the CVs of neurons in COBN and CUBN was highly significant ( t -test, p < 10 −7 ) for all input rates above 1.5 spikes/ms.
While the p values for both the clinical TNM and the proposed TB model’s staging, for the aforementioned statistical tests, are highly significant (p < 1E-07), the proposed staging yields larger test statistics.
Only SNPs mapped to the autosomes, with call rates > 0.98, minor allele frequencies > 0.03, and not in a highly significant deviation from the Hardy–Weinberg equilibrium ( P > 10 −7 ), were considered for the analyses.
In the Mushroom dataset, unlike SIPRI, the Friedman test detected highly significant ranking differences in all five metrics (all p < 10 −7 ).