“highly significant”

Three additional islands of highly significant homology ( P < 10 -5 ) were identified further upstream.

When 29 studies containing 4,390 patients who had received radical surgery (I–III) were considered, highly significant heterogeneity was detected ( χ 2 =92.48, P <0.00001; I 2 =70%).

The differences were highly significant ( p < 0.00001) for both a 2 h treatment and an overnight treatment, suggesting that if we had used the earlier material in the second trial it could have proved more effective.

There was no significant difference in MM96L when siNF1 was compared with miR-514a, whereas in MM253, particularly at higher drug dosage (10-100nM), the differences between siNF1 and miR-514a, were highly significant ( p < 0.00001) (Figure 5a ), indicating that the mode of BRAFi resistance was different, possibly due to other targeted genes of miR-514a.

While the fixed-effect model produced a highly significant result (p<0.00001), this was not upheld under the random-effects model (p=0.28), which showed considerable heterogeneity (I2=95%).

This analysis revealed a single highly significant CCA mode that relates functional connectomes to subject measures (r=0.87, P<10 −5 corrected for multiple comparisons across all modes estimated).

In contrast, five of the 13 SCC control cases exhibited P63 positivity, demonstrating a highly significant association (p < 0.00001).

The fact that the result remains highly significant ( p < 0.00001) with a narrow confidence interval after removing the outliers strengthens the conclusion that TCM external therapy is efficacious, and the initial overall estimate was not merely an artifact of heterogeneous studies.

The advantage of KRR and KMER over RR is highly significant ( p = 1 × 10 −5 ; permutation testing), but the advantage of KMER over KRR is not significant ( p = 0.093).

2011 ), which is highly significant (permutation P < 1 × 10 −5 ) ( Fig. 3 B).

Heterogeneity was negligible (I 2 = 0%), and the test for overall effect was highly significant (Z = 6.16, p < 0.00001) ( Figure 2 ). 3.10.

There is a highly significant correlation of the expression levels of individual ta-TRIM s as determined from EST and from RNA-Seq data (Pearson correlation test, P < 0.00001), confirming that the variation observed among ta-TRIM s is not an artifact of the mapping algorithm or the selected parameters.

High IL-2 levels, IFN-γ levels, CD4 subset, and CD4/CD8 ratio, and low IL-10 levels and CD8 subset in HS were highly significant ( P <0.00001–0.005).

The QIDS-SR scores after treatment were 2.2±2.3 (nondepressed range), and the difference from baseline was highly significant ( P <0.00001, Student’s t -test, one-tailed).

Highly significant (P < 0.00001) pairwise correlations were observed for 431 out of the 703 possible pairs for the 38 probesets examined in this study.

As demonstrated by the high odds ratio (log 2 (OR)>6) between all the data sets, we showed that there was a highly significant overlap in RI (Fisher’s exact adjusted p<1e−05, Figure 1—figure supplement 2a ).

These studies had highly significant heterogeneity ( P < 0.00001, I 2 = 91%), so a random-effect model was used to calculate pooled SMD.

The test for subgroup differences confirmed a highly significant difference between the results derived from these two study designs (I2 = 97.4%, p < 0.00001).

There was a strong positive correlation between DAO and histamine levels in all the groups that was statistically highly significant ( p = 0.00001) (Table 6 ).

This comparison identified 3,487 differentially expressed genes (DEGs) that met a fold change cut-off of >2 with a highly significant, Bonferroni corrected pvalue (p < 0.00001).

Association between clinical severity and age groups was highly significant (p-value <0.00001) as presented in Table 4 .

Correlation analysis between the co-expression module and traits was carried out, and two highly significant trait-related modules (|cor| > 0.75, p -value < 1 × 10 −5 ) were identified.

This dichotomy between the effects of HP1E depletion on the euchromatic and heterochromatic compartment is highly significant (p < 0.00001) and suggests a direct action of HP1E in the heterochromatic compartment, akin to its closest HP1 relative, HP1A ( Kellum et al., 1995 ; Levine et al., 2012 ).

All three two-way interactions between the main effects were found to be highly significant (p<0.00001), thus estimates and corresponding significance levels are not given for the main effects.

One group was enriched 20–30-fold relative to the GST negative control, with highly significant P -values ( P < 1 × 10 −5 ).