“highly significant”

The mean behaviour of these groups of genes in response to heat shock displays a highly significant positive correlation (Pearson r = 0.312, p < 0.00001, Spearman r = 0.314, p < 0.00001; electronic supplementary material, file S2), such that those mRNAs corresponding genes more distant from transcription initiation sites increase in abundance while those close to transcription initiation sites decrease.

Interestingly, the genomic prediction accuracies based on only highly significant SNPs ( P < 0.00001, 318–400 SNPs for survival status and 1,362–1,589 SNPs for survival time) were somewhat lower (0.3–15.6%) than those obtained from the whole set of 6,470 SNPs.

In splenic macrophages from arthritic mice treated with TNFα targeting but not with control siRNA, we found a decrease of intracellular TNFα staining indicating effective silencing ( Figure 6b ).Overall, the effect of treatment on mean fluorescent intensity value is highly significant according to an ANOVA ( F = 17.061, P < 10 −5 ).

Results remained highly significant when excluding the cross-fostered bats ( n = 11), which were only tested in year 3 ( P < 0.00001; learning : 0.19±17 vs. 0.45 ±0.19 error rates, respectively, R 2 =0.72, p < 0.00001, mixed GLM with learning set as the response variable, the origin as a fixed factor and the bat’s ID as a random effect, n = 65).

After adjusting for sex, age, and race/ethnicity in Model I, the negative association remained highly significant (β = −0.038, 95% CI: −0.045 to −0.031, p < 0.00001).

The log 10 Bayes factors recovered under each substitution model exhibit very highly significant linear relationships ( r 2 > 0.99, p < 0.00001 in all cases) and are hence independent of the amino acid substitution model employed (electronic supplementary material, S7).

The positive relationship between φ and geographical distance was statistically highly significant (Mantel test, 100000 randomisations, r = 0.375, P = 0.00001), also when corrected for beetle phenotype (Partial Mantel test, 100000 randomisations, r = 0.379, P = 0.00001; see Materials and Methods for comments regarding the value of r of the Mantel test).

However, the P value from meta-analysis was highly significant ( P <1×10 −5 ).

In models predicting RT, there was a moderately sized and highly significant main effect of congruency in which participants were slower on incongruent as compared to congruent trials ( η 2 = .177, p < .00001) and a small but significant main effect of valence in which participants were slightly slower when angry faces were the task-irrelevant distractor as compared to happy faces, but the effect size was miniscule ( η 2 = .003, p < .00001).

The generated null distribution confirmed that agreement we observed between ‘mock’ and ‘ground-truth’ ratios was highly significant ( P <10 −5 ).

The Pearson correlation for each metric across the two periods was highly significant ( p < 0.00001) and ranged from 0.86 to 0.92, demonstrating high reliability (Fig. 4 ).

An unpaired Student's t -test demonstrated that both combination treatments were significantly different to the appropriate controls, which resulted in an overall highly significant one-way ANOVA test ( P <0.00001).

The correlation between the initial decision and Δ f is highly significant (Spearman’s correlation: |ρ| = 1; p < 10 −5 ).

Testing for co-occurence of both motifs on all intergenic regions is highly significant ( P -value <10 −5 ).

However, the Bray-Curtis dissimilarity between the two data is highly significant, using the two-sided t -test with p-value <10 −5 .

However, when we combined multiple studies of plasma t‐tau in our meta‐analysis, we observed a highly significant effect ( z = 4.69, p < 0.00001).

These data demonstrate a high degree of gene expression dysregulation in the peripheral blood of patients with FA with a highly significant ( P < .00001) skewing in favor of upregulated genes.

The contrast for the 2-back to the 0-back condition for RVE (Figure 4 ) shows widespread and highly significant ( p < 10 −5 ) increases in entropy throughout the brain.

Effects of reproductive status and diagnosis on polysomnographic measures (with age as a covariate) The omnibus MANOVA (without covariate) was highly significant for RS ( P <.00001) but was non-significant for diagnosis ( P =.364) and the RS x diagnosis interaction ( P =.811).

Our study therefore demonstrated highly significant ( p < 0.00001) recovery of a VH3-enriched set of B cells and our findings therefore confirmed the selection of SpA-binding switched post-germinal center B cells that was solely based on the VH region and was apparently not affected by light chain usage.

Regression analysis revealed a highly significant relationship between 28S and 18S copy numbers ( R 2 = 0.996; P < 0.00001; Supplementary Fig. 1 in Supplementary File 3 ), with a regression coefficient close to the expected value of 1 (1.02).

Overall, there is a highly significant effect of training week across the balance beam crossing time data [ F (18 , 4914) = 5.1, p < 0.00001].

T-test statistically confirmed the highly significant response of M2e ELISA test to live virus infection at p = 0.00001(data not shown).

When comparing each variable (GI35, GI42 and DTF) between years (Figure 2b–d ), highly significant correlations were observed ( P < 0.00001) supporting a strong genetic control of these traits.

A highly significant correlation (R 2 = 0.9021, p value < 10E-6) was calculated between the two techniques (Figure 7 ).