In the entire PRDM9 protein of 894 amino acids, only 96 amino acids are in a DNA-binding turn-helix region (8 in each of 12 ZF domains), indicating a highly significant enrichment of nonsynonymous SNPs in turn-helix residues (24/31 vs. 96/894, P<0.0001 by Fisher's exact test).
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These gradients were highly significant ( P < 0.0001), independent of malignancy and robust to neighbourhoods of diverse radii (Extended Data Fig. 3g,h ).
The difference in response after booster dose between the undetectable and low Ab group was highly significant (42% vs. 87%, p=0.0001).
One-way ANOVA revealed a highly significant overall difference among groups (F(8,81) = 177.509; P < 0.0001; Tukey HSD = 8.786 MPa).
The functionalization of AP chains with the aldehyde part leads to a highly significant decrease ( p < 0.0001) in surface roughness compared to unmodified AP.
The difference in unique alleles between lines was 43,194 SNPs and highly significant ( P <0.0001).
The prevalence of highly significant comparisons (**** p < 0.0001) indicates that changes in the storage modulus were strongly formulation-dependent, validating the ability to decouple and reproducibly control hydrogel mechanical properties through polymer design.
The day of delivery was a highly significant covariate for PORCH ( p < 0.0001), not SOFA ( p = 0.09).
Highly significant up-regulation was observed in CIN III, CC, and TB categories ( p < 1 × 10 −4 ), consistent with activation of proliferative and inflammatory oncogenic miRNA programs.
The differences between the control and FRET situations were highly significant (p<0.0001).
Statistical analysis of the IC 50 values for all essential PBPs demonstrated a highly significant reduction in drug affinity in the IS 48 clinical isolate compared with the ATCC 49175 reference strain ( p < 0.0001).
In comparison to ∆ odc mutants supplemented with polyamines, the difference was highly significant, with p < 0.0001 observed on days 4, 7, and 10.
Removal of the two outliers improved the amount of variance explained by the model (76%) and turned into a highly significant relationship (r 2 adj = 0.76, F 1,14 = 49.27, P < 0.0001).
The P -values for the interaction terms between each of education level and wealth quintile and the time period variable were highly significant ( P <0.0001 in all models for both unadjusted and adjusted estimates).
Bernoulli GLMM analysis of the effect of forest fragment size on tree hyrax singing indicated that “forest size” was a highly significant covariate in tree hyrax singing probability (P-value < 0.0001) (Table 1 e, Fig.
Nonetheless, the effect of rearing condition on FF after taking z-score differences into account remained highly significant ( Con : F(1,285) = 31.39, p<0.0001; Pips : F(1,280) = 34.18, p<0.0001).
One-way ANOVA confirmed a highly significant difference in the percentage of Th17 cells across groups, F (3, 16) = 59.41, p < 0.0001, R 2 = 0.92.
2a ), with a highly significant difference between TTS-patients and controls ( p < 0.0001).
† ANOVA results indicated that the model was highly significant, as the F value for the model was 17.58 ( p < 0.0001).
and C.H.] and a high Spearman correlation coefficient ( = 0.82) and a highly significant (p<0.0001) correlation between measurements was observed.
The quadratic term for age (Age 2 ) was highly significant (β = 0.0021, SE = 0.0002, 95% CI [0.0018, 0.0025], p < 0.0001), accounting for 77.7% of heterogeneity, which indicates a non-linear effect across the age range (∼42–70 years).
Furthermore, the analysis indicates that the dsRNA construct also had a highly significant impact (p < 0.0001, Figure 3C ).
Segregating the mice by sex exposed a 4.75-fold increase of Wnt signaling activity in male LRRK2 KO mice and a 4.66-fold increase of Wnt signaling activity in male LRRK2 G2019S KI mice with both effects being highly significant ( P < 0.0001; Fig. 2 B).
theobaldi and ostracod numbers were highly significant in the wet season (Pillai's F 8, 88 = 3.959, P < 0.0001).
Correlation of ELISpot Responses to Various BK Virus and JC Virus Peptide Pools Spearman analysis indicated that, in 17 HSCT recipients with BKV-related cystitis and in 50 healthy controls, responses to the BKV LT and VP1 peptide pools showed a highly significant correlation ( r > 0.7, p < 0.0001) ( Appendix B , Table A2 ).