“highly significant”

On independent t test, all three were highly significant ( P <0.0001).

The difference at 12 weeks was highly significant (P<0.0001) ( Figure S1 ).

Results: A highly significant elevation ( P <0.0001) was found in survivin protein and total p53 levels in acute lymphoblastic leukemia children patients at diagnosis compared to controls.

In DRG cultures of both sexes, 17β-estradiol produced a highly significant (p > 0.0001) 3-fold induction of Il6 ( Fig. 5 A) and Cacna2d1 ( Fig. 5 B) expression.

Interestingly, post hoc pairwise comparisons with Bonferroni correction returned a highly significant ( p < 0.0001) difference between the pure DMEM and each of the tested cell lines, showing that the sensor is capable of detecting adherent cells with respect to medium only, with the resonant frequency of the medium containing cancer cells being consistently lower than that of pure DMEM.

3.6.2 Effect on the contents of the characteristic phenolic acid analogues For Y 1 , the developed model was found to be highly significant ( p < 0.0001), as shown in Table 4 .

The difference in incidence of GCaMP expression in Cre-expressing and Cre-lacking neurons is highly significant ( p < 0.0001; Fisher’s exact test). 10.1523/ENEURO.0373-21.2022.f7-1 Extended Data Figure 7-1 Cre-dependent expression is limited to peripheral neurons.

Comparison of the IHC and single-plex immunofluorescence revealed highly significant positive correlations between the cell densities of CD8, CD68, CD16, PD-L1 and SOX10 marker positive cells (Spearman’s rho = 0.927 to 0.750, p < 0.0001).

All models were highly significant ( P < 0.0001).

The interactions of different solutes with the type of carbon (e.g., AF or BF or CF ) and pH (e.g., BD ) populate the highly significant binary terms ( p -values < 10 –4 ) and contribute considerably to the variability in the process response.

Results Plasma 5‐hydroxyindoleacetic acid (5‐HIAA), the major metabolite of serotonin (5‐HT), was significantly higher in delirious and non‐delirious cognitively impaired subjects as compared to control individuals without delirium and cognitive impairment ( p < 0.001 and p = 0.007), which remained highly significant after excluding patients taking psychotropic medication ( p < 0.0001 and p = 0.003).

Statistical evaluation using a two-tailed unpaired Student’s t-test confirmed this increase was highly significant ( P < .0001), highlighting overnight phage amplification facilitated by metabolically active log-phase E. coli hosts [ 40 , 64 , 72 ].

Y 1 = 6.119 + 1.815 A - 4 .626B - 18 .608C + 0.436AB + 0.580AC - 0 .887BC - 0 .633A 2 + 3.269 B 2 + 15.650 C 2 Y 2 = 18.883 + 13.360 A + 49.779B - 186 .192C - 9 .063AB + 7.010AC - 24 .790BC - 3 .289A 2 - 13.194 B 2 + 150.865 C 2 The yield model (Y 1 ) had an F-value of 105.270, indicating highly significant level differences ( p < 0.0001).

The difference between both conditions, however, proves to be highly significant ( p < 0.0001) with a higher average correlation length in the presence of fluid shear stress of 33.3 μm, compared to 24.1 μm in the case of no fluid flow.

As expected, there were highly significant differences among the three regional comparisons (Friedman ANOVA: χ 2 2df = 77.82; p <0.0001).

Other Clinical Efficacy Results The mean changes from baseline in the IKDC subjective score, which ranges from 0 (worst result) to 100 (best result), were highly significant at all time points (i.e., P < 0.0001; including Month 3) and increased in their extent through Month 24 (LS mean increase from baseline: 41.6 ± 1.9 points; 95% CI: 37.9-45.4).

The Wilks’ lambda value of 0.093 was highly significant ( F (12,96) = 18.2, p = 0.0001), supporting the hypothesis that the examined individuals could be assembled in three morphological groups; the analysis also showed that the individuals were appropriately classified inside the corresponding group.

Correlation of intermediate and extensive TILs groups -combined- also showed a highly significant positive correlation with survival (p < 0.0001).

There was a highly significant difference in the serum Ki-67 concentrations between healthy dogs and dogs with non-neoplastic diseases ( p < 0.0001, Figure 2 ).

The Kaplan-Meier curve indicated that the difference between the high-and low-risk score subgroups was highly significant ( p < 0.0001) ( Figure 2F ).

The mean GI score in CHX group was found to be 0.70 ± 0.25 as against 0.66 ± 0.16 in Hi-Ora and 1.59 ± 0.55 in normal saline groups indicating least GI scores in Hi-Ora group while the results were found to be statistically highly significant ( P < 0.0001).

In particular, the difference was highly significant in the case of ALS (controls: 9098.68 ± 1210.76 pg/mL; ALS: 17,235.3 ± 1033.2; p < 0.0001), and AD (18,496.00 ± 1165.27; p < 0.001) and less in the case of ID (16,180.35 ± 1323.65; p = 0.004).

Although the serum 25(OH)D3 levels of subjects were significantly lower in March (14.11 ± 1.259 ng/mL) than in May (17.67 ± 1.342 ng/mL; p = 0.0013, paired t test), the correlation between the two sampling points was highly significant (r = 0.717, p < 0.0001).

Effect of temperature on yield traits The analysis of the variance (Table 4 ) showed that the variety had a very highly significant effect ( P ≤ 0.0001) on the days to 1% flowering, the days to 50% flowering, the days to maturity of grains, the width of grains, the weight of 1000 grains and the average yield per plant.

These revealed that the difference in mean activity between winners and losers was highly significant in the case of strong dominance pairs (W = 0.39; L = 0.20; Mann–Whitney U = 1, df 23, P < 0.0001).