“highly significant”

All comparisons between coffee rhizospheres were highly significant: INT-Coffee x ORG-Coffee p<0.0001, df = 39; INT-Coffee x TRN-Coffee p = 0.0002, df = 39; and ORG-Coffee x TRN-Coffee p<0.0001, df = 39.

Highly significant ( P < 0.0001) decrease in fasting PG and 2 h PP-PG, HbA1c, ASL, ALT, fasting total cholesterol, LDL, TG, and increase in HDL were observed after bariatric surgery.

However, there was still a positive and highly significant covariance between the male and female partner's in tGSH and GSSG ( n = 340, tGSH: F = 22.163, P < 0.0001; and GSSG: F = 5.955, P = 0.015).

The differences between the two treatments were highly significant ( p < 0.0001), for both within-group variance (higher in the independent rewards treatment) and between-group variance (higher in the interdependent treatment).

Furthermore, the median survival time (TTH) of Surgicel was lower than that of Arista, PerClot, and 4DryField, and the log-rank test showed that the difference in time to achieve hemostasis between Surgicel and each of the test articles was also highly significant ( P < .0001; Supplementary Table S3 ).

The amount of MON deposition under infinite-dose conditions was examined from three formulations: MON-NLC, MON-NLC gel, and MON in water across the epidermis, dermis, and the receiver chamber of the Franz diffusion cell after 24 h application ( Figure 11 ). A significant finding was that the MON-loaded NLC gel left much less MON on the skin surface (59.50 ± 505.81 ng/cm2) as extracted from the skin wash compared to the MON-loaded NLC (14313.11 ± 118.88 ng/cm2), with a highly significant p-value of <0.0001.

All subjects lost ≥3.0 kg total body weight, with an average reduction in BMI of −1.14 kg/m 2 which was highly significant (one sample t ‐test, p ≤ 0.0001).

The primary endpoint was archived by 53% of the patients in the rhPTH(1-84) group compared with only 2% in the placebo group, which was a highly significant difference ( P <0.0001).

A highly significant overlap of DEGs in response to reduced Ecd between the two transcriptomic experiments (72%, P ≤ 0.0001, hypergeometric test) underscored the robustness of the molecular phenotype.

It was found that the difference between the arithmetic means was statistically highly significant ( p ≤ 0.0001) Table 1 .

Median emPHasis-10 scores were 3, 19, 31 and 40 in WHO functional classes I, II, III and IV, respectively, with highly significant differences between the scores in each functional class (all p<0.0001).

The difference was statistically highly significant (p < 0.0001) and also significantly different (p = 0.0005) from healthy controls (n = 16), which had low background titers similar to the RA reactivity with untreated HSA.

Interestingly, there was a highly significant negative multilevel correlation between μ and percept duration of the object image (ρ(7439) = –0.057, 95% CI [–0.081, –0.034]; p < 0.0001).

Detailed ex-vivo phenotypic analyses, without restimulation, confirm that intrahepatic NK cells have been activated in situ indicated by a highly significant downregulation in CD16 and NKp30 in HCV and CLD groups (p < 0.0001; figure 2 B,C); downregulation in NKG2D expression (HCV cohort only p=0.01; figure 2 D); and significantly increased expression of IFN-γ and CD107a with decreased intracellular granzyme B (p<0.006; figure 2 F–I).

Significant changes were observed across all the global spatio-temporal parameters studied: Cadence (steps/min): a highly significant improvement in cadence was noted ( p < 0.0001), indicating that the intervention had a substantial effect on step frequency; Speed (m/s): walking speed also showed a significant increase ( p < 0.0001), reflecting enhanced movement efficiency; Stride length (m): significant changes in stride length ( p < 0.0001) were identified, suggesting modifications in gait mechanics over the intervention period.

The Pairwise G-tests showed that genetic differentiation was highly significant between the sorghum populations of the three groups, being highest between the Chuka and both the Tharaka (p-value < 0.0001) and Mbeere (p-value = 0.0002) populations and lowest between the Tharaka and Mbeere populations (p-value = 0.0083).

Likewise, there was also a highly significant difference between umbilical hernia and epigastric hernia ( p < 0.0001).

Similarly, for studies evaluating serum TNF-α levels, visual inspection of the funnel plot also revealed asymmetry ( Figure 4 B), which was confirmed by the highly significant results of Egger’s test for publication bias ( p < 0.0001).

There was a highly significant effect of incubation time for each powder ( p < 0.0001), and a significant difference between the moringin yield of powders at 30 min (F 1,6 = 221.38, p < 0.0001).

Evaluation by the Fischer’s exact test revealed that only the affected (n = 12) and not the unaffected twins (n = 0) had autoantibodies against the systemic autoantigen targets, and this difference was highly significant (P < 0.0001).

Discrimination based on NEXN expression was highly significant within the data set of Taylor et al , however in this case low gene expression was associated with poor prognosis (log-rank P≤0.0001).

The AHI showed the most prominent group difference (Wilcoxon-Kruskal-Wallis rank sum test was highly significant with chi 2 = 22, df = 3 p < 0.0001) with severely lower event rates in the LTG (9.45/h) compared to POAG (22.7/h) and controls (21.9/h; p < 0.0001 and 0.02, respectively).

Other covariates such as age, educational level, working status, participation in social activities, perceived health status, regular physical activities, and weight change of ≥5kg in the past year were also highly significant for both men and women ( p < 0.0001).

When the same cohort was stratified by CAB, the results showed a higher difference in DMFS (10.84%) between the low‐ and high‐risk categories with a highly significant P ‐value of <0.0001 (Figure 2 A) suggesting that CAB is a better prognostic predictor in comparison to node status.

The differential effect of aza in 4T1 Hif1b -KO versus 4T1 Hif1b -scr grafts was also highly significant in an interaction analysis ( P < 0.0001).