“highly significant”

M+F+A− genes were also significantly overrepresented on the X at a 2-fold expression threshold ( f (X) = 0.26, p = 0.03), and at larger thresholds the effect became highly significant, the frequency of X-linkage reaching 0.50 ( p = 0.0001) and 0.57 ( p = 0.0002) for 5- and 10-fold overexpressed genes, respectively.

The log-rank test revealed highly significant differences in survival across quartiles for both outcomes (p < 0.0001).

Regarding their binding to the FAS1 mRNA, the cell cycle–specific enrichment of all five proteins was highly significant ( p < 0.0001, based on the robust bootstrap ANOVA).

The gene expression analysis showed highly significant up-regulation in FLT3 of all AML samples [FLT3-wildtype (0.316 ± 0.05 folds) and FLT3-mutants (0.368 ± 0.03 folds)] in contrast of control group (P = 0.0001).

From Fisher's method, we can combine these results to one chi-squared test which is very highly significant (Fisher's method, χ 2 = 80.4, df = 10, P < 0.0001).

Regression analysis of the cured percentage in untreated patients versus the odds ratio of the ten studies analyzed and presented in table S2, revealed a highly significant linear relationship (Spearman Rho = −0.842, adjusted R2 = 0.806, P<0.0001) indicating that centers with good surgical results do not benefit from pretreatment and centers with worse surgical results benefit most from pretreatment.

While immunohistochemical analysis of 47 patients demonstrated a highly significant association between high Snail expression and poor survival ( P < 0.0001) [ 118 ], SNAI1 mRNA levels from the GDC portal ( https://portal.gdc.cancer.gov ) showed no significant correlation with patient outcomes (Fig. 2 ).

Statistical significance is indicated in the figures by asterisks, using the following standard notation: * for p ≤ 0.05 (significant), ** for p ≤ 0.01 (very significant), *** for p ≤ 0.001 (highly significant), and **** for p ≤ 0.0001 (extremely significant).

Both the model based on Ad26.COV2.S and the model based on all vaccine candidates have highly significant slopes ( p < 0.0001) in the nose.

edulis extracts inhibited HIV-1 protease activity highly significant ( p < 0.0001) at each time point during the linear curve ( R 2 = 0.9974) in a typical dose response manner.

The highly significant p values ( p < 0.0001) showed that there was a significant change in mean value from baseline for all three variables.

Similarly, Figure 4C,4D presents the analysis results of the entire TCGA dataset, showing highly significant differences in survival between the low- and high-risk groups (P<0.0001), consistent with previous results.

The model turned out to be highly significant at the permutation test ( p < 10 −4 ), as shown in Figure 9C , and predictive with 100% correct classification rate. 4 Discussion In the present study, the longitudinal multi-omics investigation on a single mother-infant dyad was proposed to examine in depth the relationships among diet composition, gut microbiota metabolism and composition during the transition from breastfeeding to weaning.

The colocalization of LAMP3 and EEA1 was calculated using the colocalization threshold plugin in the ImageJ program, and the correlation of the colocalization between LAMP3 and EEA1 was found to be highly significant ( R 2 = 0.96; P < 0.0001) ( Fig. 5B ).

However, the overall increasing trend through time was highly significant ( t = 8.45, df = 471, p < 0.0001) with an effect size of 0.0024 developmental units per year.

Comparative analysis of gene polymorphisms in groups of patients with adverse clinical and laboratory data by Plinc programme revealed highly significant differences in higher carriage of minor unfavourable alleles in the group with hyperleukocytosis for rs1800630 polymorphism in TNF gene (p<0.0001; OR1=3.943) ( Table 3 ).

For the 2- to 12-year-olds, the 40 factors showed highly significant group differences ( P < 0.0001).

AMOVA that was conducted by grouping the accessions according to their geographic regions of origin and without grouping revealed a highly significant variation among accessions and regions as well as within accessions ( Table 2 ; P < 0.0001).

Paired Wilcoxon rank sum tests revealed highly significant differences ( P < 0.0001 for BLAST and k-mer matching) in accuracy favoring the rRNA operon.

This difference was highly significant compared to all other cancer types and defined as a bona fide hotspot for CLL ( p < 0.0001, chi-square test).

The repeated measures ANOVA revealed a highly significant difference between paired and unpaired groups (F = 56.93; df = 5,114; P < 0.0001; partial η 2 = 0.71; power = 1.00).

Better correlation was achieved when using the LS system compared with the IVIS system, although in both cases the correlation was highly significant ( r = 0.9223, P < 0.0001 and r = 0.7992, P < 0.0001, respectively).

A highly significant heterogeneity was found among the studies ( I 2 = 82%, p < 0.0001) ( Figure 5 ).

The impact of measurement time on USCL changes in the 2nd cohort comparisons was highly significant (p < 0.0001).

The spatial autocorrelation was highly significant (p-values: Obsoletus group model: p<0.0001, Pulicaris group model: p<0.0001), and was estimated to be 0.41 (+/-0.09) for the Obsoletus group model and 0.235 (+/-0.09) for the Pulicaris group model for traps placed with 50 m distance.