“highly significant”

In contrast, particularly at 10 μM, a highly significant ( p < 0.0001) anti-clonogenic effect (26% inhibition) was found in MDA-MB-468 cells after three hours of exposure; meanwhile, there was a gradual decrease with increasing TQ concentration, exhibiting a significant 90% inhibition of colony formation at the highest tested concentration, 50 μM.

Overall shell shape variation among populations was highly significant (One-Way Permanova, global F =21.68, p = 0.0001) and all pairwise comparisons between locations showed significant differences ( Table 3 ).

ANOVA indicated that the model was highly significant ( p < 0.0001) with an insignificant lack of fit ( p = 0.3319 > 0.05), demonstrating good overall fitness.

However, meals were significantly smaller and shorter in NG Y2R KD compared with controls ( Figure 2 , Figure 3 ); probability density functions for meal patterning readouts further illustrate highly significant differences (p < 0.0001) in average meal size and duration ( Suppl Figs. 3f and 3g ), with a trend to shorter intermeal durations, particularly in the dark phase ( Figure 3 ).

Consequently, the AHRU group showed higher scores in all three scoring systems, with a highly significant difference (all p < 0.0001) in comparison to the non-AHRU group (CHAMPS: 2.5 (2, 4) vs. 1 (0, 2); NOBLADS: 4 (3, 5) vs. 3 (2, 4); ABC: 3.5 (2, 7) vs. 2 (1, 4)), suggesting that AHRU was potentially associated with worse clinical outcomes.

Regarding immunological response, the Spearman correlation coefficient suggests a highly significant direct link between IL-2, TNF-α, and INF-γ and radiation doses (P < 0.0001).

The stress versus basal conditions were associated with a highly significant increase in cortisol levels (p < 0.0001), as published previously ( Ancelin et al., 2013a , Beluche et al., 2009 , Chaudieu et al., 2008 ).

The ANOVA results showed a highly significant difference between the groups (F = 2820, P < 0.0001) and an R2 value of 0.9991, indicating that 99.91% of the between-group differences could be explained by changes in the relative expression of NME4.

The final number of clusters was validated based on two characteristics obtained from a discriminant function analysis, with cluster identity as the dependent variable and the original habitat variables as independent variables ( Leimeister, 2010 ), as follows: (i) a highly significant Wilks's λ (Wilks's λ = 0.046; P < 0.0001) indicating that >95% of the total variance in the discriminant scores was explained by differences between groups (clusters); and (ii) investigation of the number of errors the discriminant function analysis produced; two clusters produced the lowest number of classification errors (1%).

As this effect had only borderline statistical significance, and was not important for interpreting the results, it was collapsed and the analysis was re-run The main factor Group was highly significant, F (1,35) = 25.7, p <.0001, r 2 = .021, as well as the main factor Level, F (1,35) = 656.7, p <.0001, r 2 = .93.

By this global comparison differences between sections as well as differences between localizations were highly significant ( p < 0.0001).

Bats that were associated with the (bushmeat) value chain were more frequently positive for coronavirus RNA (25.4%) than bats sampled at other human animal (peri-domestic) interfaces (5%), and this difference was highly significant (p < 0.0001).

Selection and Functional Role of VAMP5 as a Diagnostic Biomarker of TB We followed the criteria of showing a high correlation with other EV-related DEGs, highly significant expression with a p -value < 0.0001 in both validation sets, function in vesicle-mediated transport, and a high AUC to select the VAMP5 gene, which can be a potential diagnostic biomarker of TB.

For the IGRA, comparisons between ChAdOx/ChAdOx and both heterologous regimens also revealed highly significant differences ( p < 0.0001) with stronger results for the heterologous regimens, but no statistically significant difference between both heterologous regimens ( p = 0.812; see Figure 5 ).

In contrast, longitudinal within-subject analysis revealed a highly significant upregulation in miR-146a-5p expression from T0 to T2 in both sexes ( p < 0.0001).

Surprisingly, U-HO1-RS cells differ from U-HO1-PTPN1-RS-cells by a highly significant increase of very short telomeres including "t-stumps" (p < 0.0001).

However, some weakly significant correlations were seen between the T cell response and the IgG2 response, with one highly significant correlation at week 8 (r 2 = 0.14, p < 0.0001).

The distribution of samples in the six clusters was highly significant ( X 2 = 486.6, p < 0.0001).

IHC H‐scores (Figure 4D ) revealed a highly significant difference between WT and Vasn −/− mice ( p < 0.0001).

Comparison between before 24 weeks gestations and at 37 weeks gestations showed a highly significant decrease (p<0.0001) in fasting blood glucose level.

Furthermore, the analysis indicates that the dsRNA construct also had a highly significant impact (p < 0.0001, Figure 3C ).

This model was highly significant (F = 10.29, p < 0.0001) and BMI category ( p < 0.05) was found to be an independent predictor of SIgA concentration.

Moreover, a drastic fall was observed in case of IgG4, where the difference became significant as early as on day 30 ( P = 0.0027) and was highly significant on day 365 ( P < 0.0001).

We observed a highly significant association for the model of (βATP + PCr)/iP vs. the CNR values (putamen, caudate, globus pallidus, and thalamus) (P < 0.0001) (see Table 1 ).

Highly significant ( P <0.0001; all evaluations, all readers) improvements in lesion border delineation, visualization of lesion internal morphology and lesion conspicuity versus background were noted for assessments of combined pre- and post-contrast images compared to pre-contrast images alone (Table 3 ).