“highly significant”

The enrichment of these MCTS1 pLOF variants in our male MSMD cohort without genetic diagnosis ( n = 422, 5 pLOF variants) relative to a cohort comprising both male patients without mycobacterial infections and healthy male individuals ( n = 1,932, 0 pLOF variants) was highly significant ( p = 0.00013).

Aligned rank transform three-way ANOVA analysis revealed significant effects of session and experimental day, and further demonstrated a highly significant interaction between group (TMP versus vehicle) and session (A, D, A*; P = 1.3 × 10 −4 ), indicating that cell ablation significantly but differentially affected learning in novel and familiar sessions (Fig. 5e ).

The model utilizing only data preprocessing without residual block optimization yielded a relatively lower accuracy of 75.68%, demonstrating a highly significant difference compared to the complete model ( p = 0.00013).

The difference was highly significant ( χ 2 = 14.6, P = 0.00013).

The difference was highly significant in this case ( p = 0.00013). 3.2.

In the second stage, SNPs/loci that passed a significant threshold (p < 0.05) were further pruned down with bonferroni correction and only those SNPs that were highly significant (p < 0.00013, Supplementary Table 3 ), and belonged in particular, to the extracellular matrix (ECM) i.e., Aggrecan and Fibulin-1 genes were selected for genotyping, as these genes were up-regulated and associated with aPWV in the gene profiling work.

All findings were highly significant following multiple comparison corrections ( p < .00013).

In particular, BAP1 was highly significant ( P = 0.00013, HR = 2.20, 95% CI: 1.47–3.29, more than 53 mutated tumours out of 888 total), with mutations associating with detrimental outcome in four tumour types and notable associations in KIRC ( P = 0.00079), consistent with a recent report 28 , and in UCEC ( P = 0.066).

The differences in the proportion of identified heterospecific song types between sympatric and allopatric Thrush Nightingale males were highly significant (GLM, DF1 = 1, DF2 = 15, F = 25.94, p = 0.00013), as was the difference in the proportion of Common Nightingale song types in repertoires of sympatric Thrush Nightingale and Common Nightingale males (GLM, DF1 = 1, DF2 = 15, F = 14.56, p = 0.0016).

72 kDa type IV collagenase precursor was highly significant (FC > 2; p = 0.00013).

A highly significant association between the categorical PD-L1 TPS assessed by IHC and the continuous GEP-derived PD-L1 (CD274) was identified ( p = 0.00013).

First, the large overall differences between increasing- and decreasing-rate ACC were confirmed by a highly significant main effect of change direction ( F (1,7) = 56.94, p = 0.00013; 3-way RMANOVA: change direction × change size × base rate).

A highly significant association was found between reporting of complaints and occurrence of pulmonary complications at some point in the study (X2 (1, N = 250) = 14.6309, p = .000131) as shown in Table 3 .

Without exception, a highly significant difference was observed using every deleteriousness metric with M-CAP the most significant ( p = 1.37 × 10 − 4 ) all of which would withstand correction for the three independent tests performed.

When comparing these two groups, their 4YR IQ difference was highly significant (C/R, p = 1.379 × 10 –4 ; Figure 1a , middle panel).

Both cell types showed highly significant effects on cyst volumes ( p = 0.00014, f = 14.7, df = 2,19), with no significant difference between rats treated with hNESCs and hNPCs.

Table 4 and Figure 8c list the 20 most significant small molecules along with their enrichment scores and p values; amongst these, Prestwick-1080 (enrichment score: −0.906) and verteporfin (enrichment score: −0.903) had highly significant negative scores (P = 0.00014 and 0.00176, respectively), suggesting they could restore the normal cell state.

Increase in waist circumference (cm) was another highly significant risk factor unique to COVID-19 risk of death (HR = 1.059 [1.028,1.091], p = 0.00014).

Time effect The Friedman rank sum test showed a highly significant time effect for all tested individuals’ serum RELN concentrations ( p = 0.00014; d f = 7; χ 2 = 29.09).

Correlation analysis of velocity and activation area within individual experiments revealed a highly significant correlation between these parameters both in acute experiments (Spearman r = −0.576, p = 0.00014), and in chronic experiments (Spearman r = −0.371, p = 0.043), particularly under isoflurane anesthesia (Spearman r = −0.526, p = 0.030).

No significant differences were observed amongst viral strains at 4 dpi or 17 dpi, but highly significant differences in RNA1 (** p = 0.00014) and RNA2 (**** p = 0.0000008) were observed when comparing wildtype GHu to mutant GHu 1E Pol*/Sd K802G at 26 dpi, as shown by Tukey’s HSD test (Supplementary Fig. 6b,c).

This frequency approached significance in males (95% CI: 0.758-53.32, P =0.074), but was highly significant in females (95% CI: 3.852-Inf, P =0.00014) and when both sexes were combined (95% CI: 2.993-140.6, P =6.24×10 −5 ).

P levels were highly significant ( p < 0.00014); thus, the reliability of data was accepted and MANOVA was performed for both genders for each one of the two parameters, i.e., number of graphemes and BHK score. 3.2.

A LRT test indicated that these differences are highly significant (PRE: P = 1.4 × 10 −4 ; ERE: P = 1.2 × 10 −5 ), suggesting a greater involvement of HoxA genes in female reproductive function in mammals than in nonmammalian gnathostomes.

We observed a highly significant negative correlation between ξ and the proportion of small distances Ψ ξ generated by the A-WE model ( r 2 = 0.969, P = 0.00014): the smaller ξ , the better the simulations fitted the observed data, and the greater the enrichment of the A-WE model in these simulations.