“highly significant”

Meta-analysis was highly significant (−482T meta-analysis p = 1.1 × 10 -4 ).

Of the 22 genes in the immediate neighborhood of ApoE , including ApoE itself, 4 (18.2%) were inferred as differentially connected between the wild type and ApoE −/− crosses, and this proportion was highly significant (∼8.1 fold enrichment, FET p -value<1.1×10 −4 , permutation adjusted p -value<0.001) ( Figure 5 and Figure S5C ).

The difference in distribution of AKT-sensitive and AKT-insensitive drugs to the M area was statistically highly significant (Fisher exact test: p = 0.00011).As expected, the group of AKT-insensitive drugs mapping to the M region included typical microtubuli-targeting drugs such as colchicine, vinblastine, and podophyllotoxin.

Simulations using data sets in which the observed DNA methylation levels were randomly connected to the amplicon sequences, indicated that these overrepresentations are highly significant with p-values <1.1×10 −4 ( Figure 4B ).

CYP4C64 was found to be strongly overexpressed in the thiamethoxam-resistant strains compared with the susceptible strains, and the correlation between relative protein expression levels ( CYP4C64 expression values versus actin expression values) and resistance levels (RR values; table S2) was positive and highly significant ( P = 1.11 × 10 −4 ) ( Fig. 1B and fig.

When we analyzed the statistical significance of the TAIs using VTAI (variance of TAIs) as a test statistic, [ 47 ] we found that the bat, mouse, and pig forelimb trends are highly significant ( P -values = 1.11e-4, 1.36e-4, and 3.12e-4, respectively), whereas the opossum forelimb trend is not ( P -value = 0.256) (Additional file 6 : Figure S5).

This is a highly significant overlap, given that the total number of genes in all sub-networks created by NIMMI is 6035 (p-value = 1.11×10 −4 , hypergeometric test).

The difference between average ΔF/F MAX of WT (0.084 ± 0.017) and MUT (0.019 ± 0.004) rods was highly significant (*** t = 4.40122 with 32 df: p = 1.12099 × 10 −4 ).

Conversely, in the MIIP group, only one 6-week-old piglet tested positive for the virus, a statistically highly significant difference compared to the 100% infection rate in the control group ( p = 0.0001191).

10 4 /mL blood), intriguingly, CD33 and CD64 showed a highly significant inverse profile in this study ( p = 0.00012; Figure 3 A right).

This enrichment for proteins with 3 or more copies of the RXXS motif is highly significant (p = 1.2 × 10 -4 ; G.

By applying the threshold of 5% tumor-infiltrating lymphocytes (TILs) we defined two groups, hot and cold tumors, which show a highly significant difference in TIL percentage (p<0.00012).

The co-treatment with both agents to the diabetic rats (Group 7) resulted in normalization of FBG with a highly significant difference as compared to the diabetic group ( p =0.00012) and was lower than that in the diabetic rats treated with metformin (Group 8).

Assigning ABC and GCB phenotypes to these groups of samples, Goeman's global test found a highly significant association ( p = 0.00012) of the ABC and GCB phenotypes with the DLBCL ABC and GCB predictor gene set.

Although here statistical significance was not reached for any dosage group alone, the Poisson trend statistic [ 32 ] suggested a highly significant (p = 0.00012) decreasing trend in tumor incidence rate over the dose range from 4 Gy to 16 Gy.

The increase in the percentage of dead SH-SY5Y cells under the influence of antibodies from the patients with schizophrenia was highly significant in comparison with the culture medium alone ( p = 0.00012), and the difference from the healthy donor control was even greater ( p = 0.000003).

Fungal infection experiment First we tested whether males and females differ in their survival, which is highly significant for sex (n = 378, Z = -3.84, p = 0.00012) and treatment (n = 378, Z = -4.67, p < 0.0001) (Fig. 3a ), therefore fungal treatment reduced survival differently depending on sex, and females survived better.

In this analysis, the correlation coefficient among the methods was moderate and highly significant ( r = 0.465; p = 1.2e − 4).

Nonetheless, the contingency table of type collected at each health facility ( Supplementary Table 4 , Supplementary File 1 ) reveals highly significant evidence to reject independence of type occurrence at each health facility (G statistic = 849.7, dof = 704, P = 1.25×10 -4 ) in favour of clustering of type occurrence by health facility.

The difference between the figures of the MWT values obtained from control and CFA-treated rats was highly significant ( p = 0.000125).

The associations between %-respondents for the concurrent data sets of snake encounters versus snakebite experiences showed highly significant positive correlations across the six habitat types ( r s = 0.9908, p = 0.000127, two-tailed, n = 6,), as well as across the six habitat types, three daytime periods and two seasons combined ( r s = 0.9545, p < 0.00001, two-tailed, n = 11).

When rs3747742 or rs9381040 are included as covariates in a conditional analysis, rs75932628 remains highly significant ( p = 1.27 × 10 −4 and p = 1.19 × 10 −4 , respectively) ( Fig. 1 , panel D), suggesting that the TREML2 and TREM2 signals are independent from each other.

Furthermore, in the TS cultivar, specific boundaries showed a highly significant enrichment of active gbM marks (51.6% vs. 44.3%; Δ = +7.3%, 95% CI: [3.5%, 11.1%], Cohen's h = 0.147, p = 1.28e‐04), whereas gbM levels were comparable in PN (Δ = −1.3%, p = 0.438) (Figure S9 ).

The heritability of SPH or SEM was highly significant (p=0.0001298 and p=0.0000006 for SPH and SE, respectively), with heritabilities of 23.2% (SPH) and 33.9% (SE).

In contrast, CAST 2959 and CAPN1 4751 exhibited the strongest evidence of LD among all marker pairs, with an intermediate D′ value (0.4731), low but higher r 2 (0.0851), and a highly significant chi-square result (χ 2 = 14.642, p = 0.00013).