“highly significant”

The Wilcoxon rank-sum test revealed highly significant differences between the distributions of between-class and within-class correlations ( p = 5.36 × 10 −4 ), confirming that samples from the same disease state exhibit systematically higher correlations than samples from different disease states.

Strains with transposon insertions in agrA , agrC , and ausA showed a highly significant reduction in PI uptake AUC (adjusted p = 5.4 × 10 −4 , Wilcoxon rank-sum test), confirming their reported roles in affecting bacterial cytotoxicity and validating our convergence analysis ( Figure 5F ; Blättner et al., 2016 ; Das et al., 2016 ; Laabei et al., 2021 ; Mairpady Shambat et al., 2016 ).

The ratio N tokens / N full population ( Table 3 ) shows a highly significant linear inverse correlation with the number of municipalities (R 2 = 0.23; p = 0.000544; see Fig 5 ).

Decreases in high-dose treated verses mock-treated mice were most pronounced and highly significant in the thalamus ( p = 0.000557 by a 2 sample t -test); no significant differences in staining were seen amongst groups in the hippocampus ( p = 0.825 for the high-dose group compared to the mock treated group and p = 0.839 for the low-dose group compared to the mock treated group, again with a 2 sample t -test).

Cox regression analysis confirmed this observation: For the surrogate marker-based classification, the log-rank test was highly significant (OS: p = 0.00056, PFS: p = 0.00067), and the hazard ratios for POLE and p53abn versus NSMP groups were very low and high, respectively, for both, OS and PFS (Table 4 ).

The most significant result drawn from this study was the highly significant decrease in expression of hsa-miR-205 (adj p <0.00056 by RT-qPCR validation) in DCIS lesions with intermediate/high Oncotype DX ® DCIS scores.

This difference between the homozygous and control cells was highly significant (p values = 5.6 × 10 −4 and 1.7 × 10 −7 for 1401 and 1402, respectively; Wilcoxon test).

Interestingly, histone concentrations, and thus cellularity, increased from the inner to the outer compartments of the disc, and showed a highly significant decrease in aged discs compared to young discs across all compartments ( Figure 1J , Wilcoxon p=5.6 × 10 −4 ; Figure 1—figure supplement 4B ).

Despite overall similar buprenorphine dosage, we found a highly significant correlation between cannabis use and serum buprenorphine level ( p = 0.000563).

Similarly, immunolabeling also revealed a highly significant increase in the GABAA‐α1 signal in GPi neurons at 18 months ( p = .00057), consistent with our SP immunolabeling data showing an abnormality in SP+ terminals in GPi at 18 months (Figure 12 ), and ISHH showed a trend in the same direction for GABAA‐α1 signal in GPi neurons ( p = .12720).

Co-expression with the β1 subunit consistently increased the mean peak currents, and this was highly significant overall (P = 0.00057, 2-Way ANOVA), with no significant differences between the current densities driven by splicing (P = 0.20 all 4 variants, 2-Way ANOVA).

Yet worth to mention, the canonical pathway CTLA-4 Signaling in Cytotoxic T Lymphocytes is also highly significant (p= 5.75E-04) through Ingenuity.

The differences were highly significant for AC005258 ( p = 0.00059), ZBTB7A ( p = 0.00181), SLC16A3 ( p = 0.00185), MBP ( p = 0.00478), SLC66A2 ( p = 0.00519), CTBP1 ( p = 0.00572), CDC42 ( p = 0.00572), ZNF516 ( p = 0.00572), SIN3A ( p = 0.0109), RUNX1 ( p = 0.0109), C15orf39 ( p = 0.0109), OAZ1 ( p = 0.01262), ETV6 ( p = 0.0166), DMD ( p = 0.02509), NFATC1 ( p = 0.03528), and AL591378 ( p = 0.03765).

Precipitation was not statistically significant ( p = 0.3166), whereas temperature remained highly significant ( p = 0.000596) with a coefficient consistent with the univariate model (0.496).

It was found that, in early AMD, after correction for age, the overall effect was statistically highly significant ( P = 0.0006).

Pre-pronation values of the PaO 2 /FiO 2 ratio were significantly different between groups (group S vs D: 150 ± 56 vs 115 ± 46; p = 0.006), but only pre-pronation FiO 2 remained highly significant at multivariate analysis (0.67 ± 0.16 vs 0.82 ± 0.18; univariate p = 0.0006, multivariate p = 0.001, OR 6.11).

Differences in survival times of rMVAGnGc were highly significant (χ 2 = 17.48; df = 3; p = 0.0006). 3.3.

Furthermore, there was a highly significant increase in normalised Time to Peak (TTP) BH 2 for PSY compared to those of both MD ( p = 0.0006) and MC ( p = 0.029), whereas MD and MC were not significantly different ( p = 0.75) ( Fig. 5B ).

This effect is statistically highly significant (γ = 95%, p = 0.0006).

The 24‐month LS meta‐analysis with five paired comparisons in 885 adolescents showed a highly significant weighted mean BMD difference of −0.02 (95% CI: −0.03 to −0.01) g/cm 2 in CHC‐exposed adolescents ( P = 0.0006).

Highly significant improvements were found for the main spinal parameters from T0 to T1: TK reduced from 54.22± 13.58 to 44.48± 12.80 (p= 0.0006), LL from 57.43± 11.16 to 51.13± 10.28 (p= 0.0077) and SSA from 132.87± 9.80 to 127.09± 9.24 (p= 0.0036); no significant differences were found for the other parameters.

Dynamic cerebral autoregulation The mixed linear model identified the highly significant effects of intervention ( p = 0.0006) and time points ( p = 0.0024) on PD but did not identify the interaction effect of them ( p = 0.4836) ( table 2 ).

The multiple regression analyses revealed an overall highly significant correlation ( r = 0.84 and p < 0.0006).

A moderate, but highly significant correlation ( r = 0.75; p = 0.0006) was observed between iohexol and exogenous creatinine clearances ( Figure 6A ).

The Treatment*MAOA interaction was not significant across all delays, but RMANOVA across the shorter delays (2,4,8,16 s), completed by all but one subject, showed a highly significant interaction (F(1,23) = 9.27, p = 0.0006) and a significant fluoxetine effect in the hi-MAOA subgroup (post hoc comparison, p = 0.0003).