“highly significant”

These findings suggest that the potent antitumor activity of irinotecan is further enhanced by TG6002/5-FC, with the combination showing highly significant efficacy compared to controls ( p < 0.0005).

In contrast, the singly butylated peptide ( 16 ) caused highly significant (P < 0.0005) apoptosis in a concentration dependent manner.

A highly significant relationship was found between Prm 2 promoter divergence and relative testes size ( r 2 =0.7065, p =0.0005)—independently or normalized in relation to Prm 1 promoter and to the neutral divergence assumed for INT ( figure 3 ; table 2 ).

However, the abandonment rates of den-captured bears were highly significant even when comparing with overall abandonment rates (χ 2 (1, N = 76) = 20.5, p<.0005) or when excluding those occasions where bears moved dens early in the season (χ 2 (1, N = 56) = 45.2, p<.0005).

Fisher’s exact test revealed highly significant difference between the two groups ( p= 0.0005).

After ordering each of the three methods from highest scored country to the lowest scored country for each domain and disease, Spearman's rank test showed highly significant ( p < .0005) correlations among all three of the scoring methods (Figure 4 ).

Nevertheless, the difference was highly significant ( p < 0.0005) at all the time points.

In contrast, PMA triggered a much larger increase in the C/N ratio of eERK-KTR1.2/emiRFP670, from ∼0.7 to ∼1.7, which was highly significant ( p = 5 × 10 −4 ).

The difference between these two centres was highly significant ( t =4.0, P <0.0005, CI: 2.98–9.02).

Effect of Dasatinib on Protein Expression as Assessed by Western Blotting It revealed a highly significant difference in LC3, P62 and caspase3 expressions between the four groups ( p < 0.0005).

This corresponds to a highly significant increase (p = 0.0005).

However, at 14 D, the interaction between phytase and Ca and P i levels was highly significant ( P = 0.0005), with the NC+no phytase treatment having the lowest bone ash percentage compared with the PC treatment, regardless of phytase inclusion.

The analysis of population structure by means of Wright’s [ 23 ] F ST statistic (0.42) was highly significant ( P = 5x10 -4 ).

These differences were highly significant at steps A, C and D (F = 20.97; 43.18 and 48.37 respectively; P < 0.0005) in the St-Marcellin's process, at steps A', B' and D' (F = 326; 37; P < 0.0005 and F = 11.3; P < 0.01, respectively) in Brie's process.

1 and Supplementary Data ); this difference was highly significant ( P = 0.0005).

The differences between the L p values at 0°C and those at 10°C were highly significant (p<0.0005).

Comparing the multiple and single cranial bone fractures among the fatal and nonfatal cases and applying the chi square test, multiple bone fracture was found to be highly significant for fatality p = 0.0005.

The difference in medians between RRP after cooling measured by the two protocols (1.36 ms) is highly significant (P = 5.10 -4 ); see Fig. 4 . 3.2 Cooling of wrist In the second series of experiments, RC and RCSM were tested after cooling of the wrist (12 subjects with a mean age of 38.3 ± 3.8 years).

Accordingly, the wake list AUCs were highly significant when compared to bisector’s AUC ( u -test: P < 5.10 − 4 for both the type-I and type-II ROC curves).

Mean APs, Median g‐Factors, Median Absolute Errors, and Mean CRLBs of tCho and tCr for the Three Methods and Six Acceleration Factors (Bold numbers indicate that the reference method was worse than (2 + 1)D‐CAIPIRINHA; * indicates statistical significance ( P < 5·10 −2 for AP, P < 5·10 −3 for the others); and ** indicates highly significant differences ( P < 5·10 −4 ).

Although inhibition of Mef2a was less strong than in vitro cell cultures, inhibition was highly significant (72% expression of control, p = 0.00052 in the adductor, and 78% expression of control, p < 0.0001 in the gastrocnemius muscle).

However, the difference becomes highly significant after stimulation with escitalopram ( P =0.00052) or lithium ( P =0.004).

The mean for heterocellular coupling is only about 11% smaller, but due to the large sample size is still highly significant (2 tailed homoscedastic t -test, p = 0.00052).

In contrast, GRsig emerged as a robust and highly significant predictor of survival (HR=0.79, p =0.00052582), implying that higher levels of GRsig independently correspond to a lower risk of the event ( Fig. 6A ).

Quantifying the relative F-actin intensity in the delaminated epithelia of both Lgl-KD (N = 13 invasive multilayers from 10 total egg chambers) and Lgl-KD+Keap1-OE (N = 18) egg chambers at midoogenesis revealed (1) an increase in F-actin enrichment in the multilayered epithelia compared to the monolayer and (2) a highly significant (p = 0.00053) enhancement of F-actin intensity in the Lgl-KD+Keap1-OE multilayers compared with those in Lgl-KD ( Figure 6D ).