“highly significant”

For the Ipi-N cohort, this increase in TCR.strong score was highly significant (p = 0.00097) in those with evidence of clinical benefit, which was not captured by the T cell activation metric ( Figure 7 D).

GO analysis of the genes identified in REG4 and GATA6 knockdown cells revealed a highly significant enrichment for probe sets annotated as “cell cycle phase” ( P = 9.7 × 10 −4 ).

These data amounted to a statistically highly significant association between prior autoimmune autoAb positivity and subsequent development of anti-IFN-I autoAbs (P = 0.0009766; Fig. 4 E ).

Across 15 mutation categories (see Additional file 1 ), there was a highly significant trend for users to have fewer mutations (SNVs and indels) than non-users (sign test p < 9.8 × 10 −04 ; Additional file 2 : Tables S5 and S7).

Lastly, statistical analysis revealed a highly significant (MonteCarlo, P =0.00099) correlation between DEGs of normal ageing versus bcat-1 RNAi, suggesting a global functional relevance of BCAT-1 for the process of physiological ageing.

Since highly significant ( P = 0.000996) overactivation of NFKB1 was observed in SOD1 astrocytes, we further investigated NFKB isoforms by qICC.

For schizophrenia, the statistical analysis revealed that 25 out of the top 30 gene pairs shared at least one Biological Process (BP) pathway, and the observed enrichment is highly significant ( P = 9.99 × 10 –4 , computed as ( w + 1)/(1,000 + 1) where no background iterations reached ≥ 25, thus w = 0) compared to random expectations.

The correlation between measured and simulated FT4 values was highly significant (Spearman’s rho=0.882, p<0.001, see Figure 4 ). 3.3 Computer Aided Thyroid Treatment Framework The established mathematical model was implemented in software packages to perform numerical simulation studies.

:​​ The Red module displayed the greatest shift in ME value within hybrid BC98, changing from ME = 0.33 at the AN stage to ME=−0.27 at the GF stage (ΔME = 0.60), the largest ΔME observed among all modules; (3) ​​Significant Genotype × Developmental Stage interaction:​​ Multifactor ANOVA confirmed a highly significant interaction effect for both modules (Brown: F = 12.65, p < 0.001; Red: F = 8.96, p = 0.003), strongly linking their expression patterns to heterosis and developmental transition.

Using time between baseline and death as a time-to-event endpoint a highly significant association of FEV1 baseline % with mortality risk was found [Exp(B) 0.968; 95%CI 0.952–0.984; p < 0.001].

Incidence of Citrus Canker and Huanglongbing In regard to citrus canker incidence on harvested fruits, a highly significant ( p ≤ 0.001) interaction was observed between the 19 late-season sweet orange selections and the two assessed harvest seasons, 2020 and 2021 ( Table 8 ).

Effect of Chrysin on the Weight Gain and Liver Index in High-Fructose-Induced NAFLD in Rats ( Figure 3 ) Rats fed with high fructose showed a highly significant weight gain compared to the normal control (86.14 ± 6.57 vs. 44 ± 6.76, P < 0.001).

There was a highly significant correlation between the predicted and measured tumor cell fraction ( r = 0.81, p < 0.001) (Figure 4C ).

The likelihood-ratio Chi-square is highly significant ( p < 0.001).

The effect of the experimental condition (feed presentation_herb) on all the variables studied was statistically highly significant ( p < 0.001).

Although the LS174T cell positivity for mHsp70 was highly significant between the wt and LDH -/- sublines (p ≤ 0.001), there was no remarkable difference in their MFI referring to the mHsp70 density per cell ( Figure 1B ).

Statistical analysis of the data presented in Table 1 using one-way ANOVA revealed highly significant differences between groups (F(8,1251) = 23.8, p < 0.001).

The chi-square value for age was found to be 160.88, with a highly significant p-value <0.001.

The regression models were highly significant ( p < 0.001), with coefficients of determination ( R2 ) ranging from 0.92 to 0.99.

On intergroup comparison, it was found that there was a statistically significant difference in terms of marginal adaptation ( P = 0.024) and retention ( P = 0.023), while a highly significant difference was observed in terms of surface texture and anatomic form ( P < 0.001) at the end of 1 year [ Table 1 ].

A highly significant higher level of sCD200 was found among cases as compared to controls (P<0.001), while a significantly lower level of CD200 R expression on both lymphocytes and monocytes was detectable in cases as compared to controls (P < 0.001 in both instances) Table 1 .

Using the two-factor ANOVA model, there was a highly significant E effect ( p < .001) on reducing sclerostin levels and a borderline significant ( p = .052) T effect on increasing sclerostin levels, suggesting opposite effects of E versus T on sclerostin levels.

Results PD1 was brightly expressed in 91.5% of the cases than control sample with highly significant difference ( P = .001).

We found a highly significant inversely proportional correlation between the LL-37/leukocyte count ratio and the severity of COVID-19 ( p < 0.001) (Fig. 2 b).

To aid in interpretation of hazard ratios we scaled selected variables either by fixed factors or to a proportion of the sample median before modeling, as some features showed highly significant associations ( p > 0.001) but HRs and confidence interval limits of nearly 1.00.