“highly significant”

Moreover, pairwise Levene’s tests for equality of variances between ancestry tracts were all highly significant ( p < 1 × 10 −16 ).

Statistical analysis (MANOVA) of the original data obtained from the cell populations indicated a highly significant difference between them (p<10 −16 ) suggesting that the nuclear SIRT1 pattern reflects structural differences in the nuclei between the cell populations.

The PPI network comprised 51 nodes and 283 edges, with a highly significant enrichment (PPI enrichment p-value < 1.0e-16) as shown in Figure 4A .

Figure 3 illustrates the interactome for DS3, featuring 257 edges, 57 nodes, an average node degree of 9.02, and a highly significant PPI enrichment p -value of <1.0 × 10 −16 .

The heritability estimates for all subfields, displayed on the plot’s diagonal, were highly significant (all p -values < 1 × 10 −16 ), ranging from h 2 = 0.14 of the parasubiculum to h 2 = 0.27 for the hippocampal tail.

STRING analysis revealed highly significant connectivity between almost all input genes (enrichment p -value < 1 × 10 −16 ), suggesting that TCF19 may be regulating one cluster of interconnected genes ( Figure 2 B).

Starting with the GO gene sets, we found a highly significant enrichment in genes related to the innate immune response particularly (p = 1.×10 −16 , FDR = 1.36 × 10 −12 ).

Moreover, using paired t tests to validate these differences, we found highly significant differences between the observed distributions of FD and PD and the null models ( P < 10 −16 , t test).

The perfect association of the haplotype was highly significant (p<10 −16 ).

This detrimental effect of antibiotics was highly significant among the phyla Bacteroidota and Firmicutes_A (p < 1e–16, OR 0.7) and observed at various host ages ( Figure S2 E).

Protein–protein interaction (PPI) analysis revealed a highly significant network connectivity among these proteins ( p < 1.0 × 10 −16 ).

It exhibits highly significant protein interaction enrichment ( p < 1 × 10 −16 ).

By comparing the joint mt / apico haplotype frequencies ( Supplementary Table 3 ), we found that the dependence between mt and apico was highly significant ( χ 2 =64,921, d.f.=39,566, P <10 −16 ), providing strong evidence of co-inheritance of the two organelles.

As reported in the Results section, the resulting network showed a highly significant protein–protein interaction enrichment ( p -value = 1 × 10−16), indicating that the observed interactions are far more frequent than expected for a random set of proteins of comparable size.

The C > A mutations observed were associated with highly significant sequence-selectivity, being marked by an excess at CpCpT (NGCII082, odds ratio (OR) = 3.2, P -value < 10 -16 , χ 2 test) or TpCpA sites (NGCII092, OR = 1.7, P -value < 10 -16 , χ 2 test) and extensions of these motifs (Materials and methods; Note 6 and Figure S6 in Additional file 1 and Table S14 in Additional file 6 ).

The network comprised 87 nodes and 1, 198 edges and showed highly significant enrichment (PPI enrichment p < 1.0 × 10 -16 ).

However, the overlap between the two categories of the intergenic transcribed regions is highly significant (P-value < 10 -16 , chi-square test)." Contributor Information Philipp Kapranov, Email: philippk08@gmail.com.

The discovery and validation gene counts were 2.8 and 1.2 enriched respectively in the 38 Cluster 2-like NPH astrocytes and highly significant (chi-square test of expected versus observed UMIs; p < 1E-16).

The PPI network exhibited a highly significant enrichment, with a p-value of <1.0e-16 and obtained from a random set of proteins which is a distinguishable property of STRING analysis, suggesting that these proteins are more interconnected than expected by chance, pointing to their potential roles in Parkinson’s disease pathology ( Figures 3 , 4 ).

41 All clocks demonstrated a strong and highly significant correlation with the biologic age, with the skin and blood clock demonstrating the strongest correlation (Pearson R = .96; 95% CI, 0.959–0.97; P <1 × 10 16 ) ( Figure 8 A ).

In each of the hippocampus, amygdala, thalamus, caudate, nucleus accumbens, and brainstem, one or more diffusion metrics were highly significant with P < 10 −16 .

Again, the correlation between the P values of the 1000 top variants for the classical and mixed-effect Cox models was highly significant ( r = 0.97, Spearman P value < 10 −16 (Supplementary Fig. 4b )).

However, the effects were clearly non-random, with highly significant enrichments of specific pathways and an overall protein–protein-interaction enrichment p -value of <1.0 × 10 −16 upon bioinformatics analysis at the STRING (search tool for the retrieval of interacting genes) webpage in Heidelberg.

ChIP-seq showed there was a highly significant correlation ( p values < 10 −16 ) between ER binding fold changes induced by the addition of elacestrant or fulvestrant in the three cell lines tested (Pearson correlations with p values <10 −16 ; 0.78 MCF7, 0.47 MCF7-LTED wt and 0.60 MCF7-LTED Y537C ) especially in regions where there was increased ER binding after treatment versus E2 (Fig. 4A ).

Using STRING analyses, we identified a highly significant protein–protein interaction (PPI) enrichment ( P = 10 −16 ) only for the downregulated genes of H2A.Z.1‐depleted cells.