“highly significant”

One-way analysis of variance (ANOVA) using the cluster size as the factor variable found that both results are highly significant ( P < 10 −16 ).

Overall, a test of independence between the risk score tertiles and the potentially AAMR CNV count classes shows a highly significant association ( P < 1 × 10 −16 ) for both Fisher's exact test and a χ 2 test.

The correlation between HNRNPK binding events and nuclear enrichment was highly significant when controlling for transcript length and expression levels (R=0.2, P<10 -16 in HepG2 cells and R=0.07, P<10 -16 in K562 cells).

In sharp contrast, the STRING analysis found a highly significant connection enrichment in the MSI-H overexpressed proteins ( Fig. 3 B ; p -Value < 10 −16 ).

The perfect association of the haplotype was highly significant (p<10 −16 ).

We do detect a highly significant enrichment of marine-freshwater differentially expressed genes, as predicted ( P < 10 −16 ).

The fits showed a highly significant effect of light angle (p < 10 −16 ) on the perceived walking direction for both true walking directions (AWAY and TOWARDS).

However, the overlap between the two categories of the intergenic transcribed regions is highly significant (P-value < 10 -16 , chi-square test)." Contributor Information Philipp Kapranov, Email: philippk08@gmail.com.

The PPI network analysis revealed highly significant connectivity ( p < 1.0e-16), with functional enrichment in protein refolding and cellular stress response.

The network comprises 26 nodes and 131 edges, with a highly significant PPI enrichment p < 1.0e-16.

As illustrated in Figure 3 , there was a highly significant correlation between the genetic and transcriptome covariances for this set of genes ( r = 0.035, P = 1.0 × 10 −16 ; Figure 3 ).

By comparing the joint mt / apico haplotype frequencies ( Supplementary Table 3 ), we found that the dependence between mt and apico was highly significant ( χ 2 =64,921, d.f.=39,566, P <10 −16 ), providing strong evidence of co-inheritance of the two organelles.

This highly significant directionality ( P < 10 -16 ) is not expected by models of statistical positioning, but suggests instead that Isw1-dependent shifts reflect its function during elongation [ 15 ].

A highly significant correlation (half-life: Spearman's r = 0.67, P ≤ 1e -16 ; decay rate: r = 0.64, P ≤ 1e -16 ) was obtained, supporting the initial finding that RNA stability becomes more pronounced with increasing distance from the promoter.

A highly significant proportion of these genes (Figure 4A and B and Supplementary file 5) (599, hypergeometric P < 1e−16) are also within 25 kb of 961 TP53 binding sites, potentially representing direct TP53-induced target genes (Figure 4B and C ), many of which, such as CDKN1A , are associated with multiple TP53 sites.

41 All clocks demonstrated a strong and highly significant correlation with the biologic age, with the skin and blood clock demonstrating the strongest correlation (Pearson R = .96; 95% CI, 0.959–0.97; P <1 × 10 16 ) ( Figure 8 A ).

Results In the independent validation set, the hazard score calculated from 54 single nucleotide polymorphisms was a highly significant predictor of age at diagnosis of aggressive cancer (z=11.2, P<10 −16 ).

This overlap is highly significant ( P -value <10 −16 , hypergeometric test where the intersection is 9000 between 700 000 conserved islands and 60 000 DHSs, assuming a total of 30 000 000 potential loci), consistent with the idea that sequence conservation at overlapping unannotated conserved island/DHS loci reflects the importance of regulatory factor binding to DNA.

In spite of different cell death phenotypes of these mutants, RNA-seq revealed that all three mutants down-regulated the same 95 genes and up-regulated the same 9 genes, a highly significant portion of the total transcriptome (p<10 −16 ) ( Figure 5 and Table S5 ).

Statistical analysis (MANOVA) of the original data obtained from the cell populations indicated a highly significant difference between them (p<10 −16 ) suggesting that the nuclear SIRT1 pattern reflects structural differences in the nuclei between the cell populations.

However, while the difference between term and moderate to late preterm TREC was significant but not meaningful, 108 (70–170) vs 101 (64–164) median TREC ( p = 0.0017), the differences between term and extremely preterm, 49 (29–92), or very preterm, 88 (52–149), were both highly significant ( p = 1E −16 , p = 4E −6 , respectively) and meaningful.

The network comprised 87 nodes and 1, 198 edges and showed highly significant enrichment (PPI enrichment p < 1.0 × 10 -16 ).

In particular, there was a highly significant overlap ( p < 1E-16, one-sided Fisher’s exact test) between the top 56 enriched cytobands from the CBTN cohort and a top set of 79 enriched cytobands from the PCAWG cohort, involving 29 cytobands (Figure S1e).

Accordingly, the removal of these functional factors leads to a highly significant association between GC content and recent positive selection (slope = 0.49; P < 1E−16; supplementary Results S3: table S4, Supplementary Material online).

Moreover, the Pearson correlation between association strength of shared SNPs across the two tissues was highly significant ( P <10 −16 ), highlighting the conservative genetic architecture of C18∶1, C18∶3, C20∶0 and C20∶1 in the two tissues.