“highly significant”

In the intervention group, all subdimensions showed highly significant changes ( p < 0.001), with large effect sizes (Cohen’s d = 3.61, 3.64, 3.58, 3.70, and 3.75, respectively).

All clinical stability tests—Anterior Drawer, Lachman and Pivot Shift—showed a highly significant reduction in anterior laxity post‐operatively ( p < 0.001), indicating successful restoration of the joint's mechanical integrity [ 29 ].

According to Table 3 , farm size exhibits a highly significant positive correlation with information usage (p = 0.001), suggesting that larger farm sizes enable more intensive information application.

Highly significant differences in basal AMH among groups were observed (P < 0.001).

Of particular note, the analysis revealed a highly significant and steep increase in amoxicillin resistance ( Figure 4 ) from 2018 to 2024 (OR per year, 1.60; 95% CI, 1.31–1.96; p < 0.001).

Smooth curve fitting analysis indicated that the nonlinear effect of the smooth term in the overall population was highly significant ( p < 0.001), suggesting a complex nonlinear relationship between VAT volume and CVD risk.

There was a highly significant correlation between the PAM score and the postoperative BCVA ( P < 0.001, Chi-square test).

Regarding the color coordinates, the difference between the tested groups was highly significant in lightness (ΔL∗) ( p < 0.001), while no significant differences were found in green/red value (Δ a ∗) and yellow/blue value (Δ b ∗) ( p > 0.05).

This maturation effect was highly significant for all markers (p<0.001) ( Table 1 ).

The effect of time was highly significant ( P < 0.001), with the difference between the groups emerging at about 3 h and increasing throughout the test (Fig. 3 ).

Overall, the model was highly significant and explanatory of TTHM concentrations ( F 3,92 = 135.3, p <0.001 , R 2 = 0.82).

As expected, highly significant differences were observed in cortical regions ( p < 0.001) when comparing 18 F-Flut(+) and 18 F-Flut(–).

Notably, Eggerthella lenta showed a highly significant positive association with Kawasaki disease ( p < 0.001), with an odds ratio (OR) of 2.984 × 10 5 and a 95% confidence interval (CI) ranging from 2.900 × 10 2 to 3.070 × 10 8 .

From these listed genes, we selected the top 27 genes, which have a highly significant difference (p < 0.001) as shown in Table 1 .

RM ANOVA showed a highly significant effect of OBX model ( F (1,20) = 81.42, p < 0.001), feeding status ( F (1,20) = 20.99, p < 0.001), day ( F (9,180) = 1175.89, p < 0.001), day*OBX model interaction ( F (9,180) = 81.90, p < 0.001) and day*feeding status interaction ( F (9,180) = 14.80, p < 0.001).

The overall fitted model was highly significant as the coefficient of covariance parameter indicated the p -value < 0.001.

At a higher magnification ( Figure 6B ) the enhancement of oil droplets formation was readily observed (panel d), increase that is statistically highly significant (p = 0.001 for resistin vs. resistin+heparanase).

These values were found to be highly significant by paired t -test ( P < 0.001).

Likewise, liver bacterial load results showed that compared with the PC group, the P and C groups exhibited significantly reduced liver bacterial load (P < 0.05), while the CPH and CPL groups demonstrated highly significant reduction ( P < 0.001) ( Fig. 6 D).

On the other hand, the values of total N content in CGE and GDE were similar but highly significant ( P < 0.001) compared to total N content in OGR (Table 2 ).

The obtained CV-ANOVA results demonstrated a highly significant model performance with an F-value of 267.637 and an extremely low p-value (P < 0.001).

The initial column (Table A6) considers only ED attendances and migration status in 2017, revealing that first- and second-generation immigrants experience positive and highly significant differences of 2.9% and 5.1% (1), respectively, compared to Swiss natives ( p < 0.001).

Two highly significant ( p < 0.001) molecular signatures were identified by Gene Set Enrichment Analysis of BAP1 calling-card target genes associated with gene expression response to BAP1 depletion (see Additional file 7 ): an Epithelial-to-Mesenchymal Transition (EMT) signature was associated with up-regulated genes; and a polycomb-mediated lysine27-trimethylation of histone H3 in Embryonic Stem Cells was associated with down-regulated genes (Fig. 4d ).

A highly significant weight gain of 1 kilogram was observed at 8 weeks with prazosin compared to baseline (p < .001), and this gain was also statistically significant when compared to the 8-week weight changes in all other groups that had experienced either weight loss or no mean weight change (p < 0.05).

Correlation was highly significant (p<0.001 for all).