Barely Significant
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likely to be significant

404 sentences · 404 papers · 18,949 search hits before verification · confirmed specimen

Sighted at

p=0.054

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

14 , 15 In these people, disproportion adipose distribution (tending towards central and visceral adiposity) and adipose dysfunction, sarcopaenia and early beta cell failure are likely to be significant drivers of MASLD and T2D development. 12 – 14 As a result of the linked pathophysiologies, MASLD is extremely common in patients with T2D, with prevalence demonstrated to be as high as 65–70%, and studies using liver biopsy-based diagnosis demonstrating prevalence of over 90%. 16 – 18 In addition, there is a bi-directional, synergistic interaction between the conditions, which leads to worsening diabetes control, increased risk of MASLD progression and increased non-l iver morbidity and mortality beyond that already conferred by T2D alone.
Nevertheless, when a sequential Bonferroni [ 42 ] adjustment was used to avoid the so-called “multiple comparison problem” (where with a significance threshold p -value of 0.05, 5% of tests are likely to be significant by chance), only two loci (HPRTB and DXS10148) were found to be out of HWE ( Table S2 ).
For example, antitumour drugs such as methylation inhibitors 5-azacytidine and 5-aza-2′-deoxycytidine can specifically inhibit the methylation of certain genes that suppress tumour growth and metastasis and regulate cell cycle, playing a corresponding role in curbing tumour proliferation with fewer side effects; these drugs are likely to be significant in cancer treatment in the future ( 170 , 178 - 181 ).