“likely to be significant”

As at the rhombic lip, Crabp1 is likely to be significant in transiently facilitating or terminating intracellular retinoic acid signalling as cells drop out of division.

Hence the clusters with a larger number of genes seem more likely to be significant while small sized profiles are penalised.

In real applications to complex bio-molecular data, we suggest to apply both Bernstein -based and χ 2 -based procedures: structures discovered by both tests are likely to be significant, and Bernstein -based tests can discover potential structures not detectable with the more selective χ 2 -based test.

Hence a random subset with the same numbers of genes as the original intersection would be likely to be significant.

This aspect of NFAT regulation is likely to be significant, since both the extent and duration of NFAT activity have recently been shown to influence the qualitative pattern of NFAT-dependent gene expression induced during T cell activation [ 28 ].

Substitutions in the vicinity of the substrate binding site may influence the affinity of the neuraminidase for its substrate, whereas remote substitutions in the ectodomain are less likely to be significant.

Because having CKD increases the risk of progressing to ESRD in patients with VUR, risk factors for progressing to CKD are highly likely to be significant predictors for the progression to ESRD.

This small but reproducible signal is likely to be significant, as it was abolished in an mre11 mutant, in which ssDNA forms more slowly ( Lee et al., 1998 ) ( Figure S4 ).

These are the patients in whom the consequences of treatment with an antibiotic ineffective against the pathogen causing the exacerbation are likely to be significant, with clinical failures, hospitalizations and early recurrences likely.

Furthermore, the clinical benefit of reducing unnecessary radiation exposure is likely to be significant.

These are the genes whose transcriptional control is most likely to be significant for the response to biologically relevant UV doses.

There are likely to be significant differences between the rats used here other than their pigmentation phenotype, and include variation in genetic background and ocular light experience, among other difference.

PYY-positive endocrine cells are often surrounded by Y 1 -immunoreactive epithelia and nerve fibers but are themselves Y 1 -negative [26] ; thus a paracrine rather than an autocrine action for PYY is likely to be significant in human colon.

The downstream effects of the elevated levels of important regulatory proteins on cellular signal pathways are likely to be significant.

If this brings to light any differences likely to be significant the next step will be to look for similar differences between the differently reacting skins of young New Buffalo and CBA mice.

Therefore, we believe our results are more globally applicable to LCIS and that alterations identified in other pathways not specifically validated in this study are nonetheless very likely to be significant.

It is reasonable to assume that there are likely to be significant differences between adjunctive use of Web-based interventions compared to fully automatic Web-based interventions like ours that do not involve any in-person contact and that deliver the intervention only by a rules-driven algorithm.

As a result of this analysis, we concluded that changes in abundance are likely to be significant if they are greater than 6-fold.

Exclusion criteria Exclusion criteria were chosen to avoid inclusion of patients whose AARR is likely to be significantly biased by underlying diseases or medications.

In summary, the combined vasodilator effects of increased basal NO levels and increased AT2R expression in INSR subjects are likely to be significant contributors to the observed increased arterial compliance in the early stages of INSR states, and may represent an early response to vascular damage, 58 some of which is induced by increased AT1R expression.

Conclusions While VPA appears safe and well-tolerated in this initial pilot trial, these data suggest that weight gain and carnitine depletion are likely to be significant confounding factors in clinical trials.

This attenuation is likely to be significant since noradrenaline reuptake inhibitors result in only moderate increases in blood pressure.

2), differences in mean LR are likely to be significant.

Clustering of top-scoring sites in a group of related genes is likely to be significant when it arises from an unbiased genome-wide analysis. miR-7 and miR-2 were selected for target validation. miR-7 Regulates Notch Targets Among the top 10 predictions for miR-7 , we found Enhancer of split ( E(spl) ) and Bearded ( Brd ) complex genes ( Figure 3 A).

In these circumstances, exposure of children to the disease is likely to be significant; and therefore, prevention of serious childhood tuberculosis should remain a priority.