“may be significant”

These findings may be significant to the field of EAS where low-level indicators of stress are difficult to ascertain yet could be contributing to problematic behaviors in horses.

The clinical consequences of such variations may be significant.

Understanding the demographic trends of patients requiring wrist arthroscopy procedures may be significant for better addressing the future of this surgery and the related health service planning.

The third factor may be significant heterogeneity across studies.

Therefore, it is important to study the genetic components of AC to identify susceptible populations according to genotypes; such findings may be significant for the prevention and treatment of AC.

In conditions of malnutrition, such as cancer cachexia and anorexia, there may be significant alterations in the production of many proteins, such as leptin, secreted from adipocytes with important metabolic and regulatory implications ( 45 ).

Considering that “the potential consequences of overdiagnosis and overtreatment may be significant and include such harms as the psychological and behavioral effects of disease labelling, physical harms and side effects of unnecessary tests or treatments, unnecessary treatment negatively affecting quality of life, increased financial costs to individuals and wasted resources and opportunity cost

The cooperative motions of the Site3 GlcNAc and the Phe410 side chain may be significant from the mechanistic viewpoint.

Naturally and at any age, there may be significant variations in AMH levels among women [ 12 , 13 , 19 ], however the greatest variability is seen in women aged ∼25 years.

This pattern may be significant because basal and lateral adhesion signaling are coordinated through multiple pathways to promote or inhibit cell migration [ 56 ], suggesting a possible role for CLCA2 in cross-talk between AJ and hemidesmosomes.

Second, there may be significant differences or similarities between different classes of medical images, which may lead to the inability of some hypothesis-based or a priori algorithms to accurately depict the distribution and probability of image data.

It was reported that oxidative stress initiates eryptosis, and the release of MPs, generated during this process, may be significant in microvascular dysfunction.

These findings may be significant in light of future trials involving yet more sophisticated closed-loop systems and in which equipoise regarding the two study arms may be yet more imperative (see Discussion ).

This may be significant since there is increasing evidence that the integrity of the sperm chromatin at the actual time of fertilization influences embryo survival [ 9 ]; poor sperm DNA integrity may account for some of the infertility commonly thought to lie with mares.

Among the available subjects, 15 were Ki67-negative and 3 were Ki67-positive, but a p -value of 0.01 suggests the pilot result may be significant, even with the limited sample size.

For example, stimuli may be significant for successfully performing a task (task‐significant stimuli), such as detecting a certain target in a visual search paradigm.

Furthermore, some studies have shown that interhospital transfers are not without risk, as they may cause depression, pain, and loss of independence, functional status may worsen, patient satisfaction may diminish, the cost of transfer may be significant, and quality of care issues may arise (pressure ulcers, falls, transitions of care leading to medication errors). 17 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 Without understanding the risks of iatrogenic harm, the likelihood of intervention at the receiving hospital and alternative care options, patients and informal caregivers cannot select the care most consistent with their goals and values.

Nevertheless, there are some variations in cell lineage that may be significant in the development of natural diseases.

Caution is advised when interpreting the results because these sites may be significant contributors to ventilator‐associated infections.

Taken with the interactome observed for the 9 mRNA binding/splicing factors, there may be significant opportunity for overlap between these factors and other splicing factors in contributing to regulation of BMP4-dependent transcription.

There may be significant advantages of receiving thalidomide for maintenance therapy after transplantation: resistance may be avoided; the risk of thromboembolism can be reduced, since this risk is highest during induction therapy; and the incidence of neurotoxic effects should be reduced with the later introduction of thalidomide at lower doses (50 to 100 mg) during maintenance therapy.

Our observation of calvarial centripetal proliferation with trabecular formation associated with CPA represents a novel finding that may be significant in elucidating the pathogenesis of CPA.

There may be significant drawbacks with this method, however.

Our observation of increased activation with greater value of the potential gain may be significant insofar as it may be the functional neuroanatomical realization of over-valuation of the potential benefit of risky choices which has previously been reported in HIV+ individuals [19] .

Finally, both calorie intake and inflammation processes may be significant co-determinants of oxidative and antioxidant potential and future studies should also take into account dietary data and inflammation markers.