Barely Significant
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may be significant

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In the literature

Environmental factors, such as cellular and physical stress, can also influence miRNA expression (Lukiw & Pogue, 2007 ; Mannironi et al., 2013 ; Rocha, 2007 ), and thus there may be significant genotype‐by‐environment (GxE) interactions present, whereby MBSVs are only pathologically relevant within the context of other environmental risk factors for psychiatric disease.
Meanwhile, due to different random fluctuations in the absolute molecule numbers of KaiC phosphoforms, regulation of these hexamers in gene expressions can swing among deterministic, pseudo-stochastic or stochastic modes, which may be significant to the stochastic gene expressions in the out-of-steady-state system [40] .
Circadian KaiC phosphorylation: a multi-layer network.
PLoS Comput Biol · 2009 · PMC2773046
However, there are several points of concern: (a) our approximate and exact equations do not include the effects of wire-to-wire capacitances, and these may be significant; (b) the out-of-phase component of V H (3,4) has been reduced to about 1 × 10 −4 R H I Ot by removing lead 5, but great care must be taken to correct for the in-phase (phase defect) contributions of the bridge components used to null the out-of-phase signal because these in-phase (phase defect) signals can be unintentionally added to the real, second-order terms of the in-phase component of V H (3,4) in Eqs.