“may be significant”

Similar experiments have been carried out with P450 isozymes 2E1 and 2B1. The possible occurrence and role of FMO in the nervous system appears to be important not only because TDZ and several of its metabolites have similar biological properties and activation within the target tissue may be significant but also because the FMO has been shown to activitate phosphonates by metabolism to their oxons (43,87,88) and to carry out the sulfoxidation of phorate and other Environmental Health Perspectives * Vol 104, Supplement I * March 1996 102 PESTICIDES AND ENVIRONMENTAL HEALTH insecticides.

It may be significant that the measured stoichiometric ratio of Na efflux/ATP used is less than 3, as also observed by Garrahan and Glynn (1967a) and Blostein (1983).

Although their age distribution is similar to that of express terminal sorters, there may be significant differences in terms of work experience, physiological fitness, and lifestyle habits.

There may be significant differences between youth who have not disclosed their orientation versus those who have in terms of family functioning, drug use, sexual risk behavior, and depressive symptoms.

Thus, the progressive accumulation of uremic metabolites, especially ones that may be poorly filtered by conventional dialysis membranes, may be significant contributors to the progressive decline of mitochondrial health observed in patients with CKD.

We also agree with the reviewer's second point that there may be significant variability in the level of autofluorescence exhibited by touch samples.

On Mars, the effects of any electrical conductivity enhancement are likely small, but on Titan they may be significant.

By performing computer simulations, as well as experiments, Nell and Myers (7) determined that even if the focal spot is targeted more than 4 cm from bone, heating at the interface may be significant.

While thermal stresses may be significant under field conditions, particularly for large-area patches (1000 × 1000 mm) subjected to wide diurnal or seasonal temperature ranges, their quantification is considered beyond the scope of this investigation and is identified as a priority area for future research.

The processes observed by the Williams group may be significant for ion formation in previously disclosed ion sources, including ESI and ambient ion sources.

One limitation of the study is that patients were recruited at various stages of the disease process therefore there may be significant variation in time frame for weight loss.

Since the number of people in the vaccinated group was significantly smaller than that in the unvaccinated group, there may be significant differences in other key characteristics, making the comparison results between the two groups inaccurate or subject to selection bias.

Thus, like in larval transmission, it may be significant for YFV transmission or persistence in enzootic foci in sylvan environments.

The potential efficacy of low doses (25 and 50 ng/mL) in reducing factors of the NF-κB and MAPK pathways, similar to COX-2 and iNOS, may be significant for inflammation treatment.

Other studies have suggested that male sex and cholesterol levels may be significant risk factors for high vascular calcification in young adults ( 20 - 22 ), while others have proposed that psychological factors and emotional stresses may also play a role ( 23 , 24 ).

Even with an accurate set-up, internal displacement of the tumour may be significant: Hansen et al .

Nursing mothers may have to limit amount of breast milk intake as distribution may be significant.

20 Thus, the order in which bevacizumab plus chemotherapy and EGFR‐TKIs are administered to patients harboring EGFR mutations may be significant.

Among these mechanisms, the release of transforming growth factor (TGF)-beta and Th2 cytokine production, ameliorate myelination ( 25 ), inhibiting B and T cell migration through the blood brain barrier ( 26 ), increasing cytokine levels such as interleukin (IL)-10, tumor necrosis factor-alpha, and IL-4 ( 27 ) and decrease in matrix metalloproteinase activity ( 28 ) may be significant.

There may be significant heterogeneity due to the different types of Tai Chi and duration and frequency of practice.

Studies suggest the effects of PRVS may be significant in daily life in healthy non-clinical individuals [ 6 ].

A further consideration is the area around a person’s home in which the contribution of green space may be significant with respect to their health.

Particularly concerning are families because the increased poverty rate is more prevalent among them compared with the general population, and because children’s consequences may be significant [ 4 ].

When non-sleepy/less symptomatic patients were evaluated, a DBP reduction of less than 1 mmHg was found in compliant patients and may be significant, but its clinical meaning is debatable [ 11 ].

Regardless of the dust-source region or the agricultural region being impacted, the economic and possible human consequences that may result from ignoring obvious transoceanic routes of dispersion may be significant and, more importantly, may directly affect the ability of a region to optimally produce and sustain food supplies.