“modest significance”

Therefore, our results, especially for factors with modest significance levels, should be considered hypothesis-generating rather than definitive.

We discovered several other directional effects of modest significance ( Table 2 ), including lagged health on closeness (0.45, 0.09–0.81) and lagged prosocial behavior on closeness (0.46, 0.02–0.91).

A post-test LR of 2 was also of modest significance, increasing the disease probability by 15% [ 26 ].

The FAX-1 LBD was most similar to the NR2F2 COUP LBD, albeit with modest significance.

2013 ), which may explain the modest significance level for some of our results.

However, such level of clinical response is of modest significance to patient functionality, while an ACR 70 response that would enable patients to work and look after their family is reached in only 20–25%.

Remarkably, these genes exhibit significant importance in PheSeq analysis, despite showing relatively modest significance in sequence analysis.

For each SNP, checking the expected and observed genotypic/allelic frequencies in single groups of affected cases and healthy controls, a modest significance in deviation from the Hardy–Weinberg equilibrium is highlighted, regarding the group of positive controls for genotypes containing allele C of the polymorphism rs10859871 (VEZT) (HWE p -value = 0.0435.) This violation of the proportions of the Hardy–Weinberg equilibrium could constitute a bias selection ( Table 4 ).

[ 11 ] reported a modest significance of VEGF -2578C/A polymorphism as a risk factor for bladder cancer.

Given the sample size, the relatively modest significance levels are surprising, but may result from the large variance seen both within and across age and diagnostic groups ( Figure 2 ).

Motivations: Professional versus Jury-Determined Standards Before delving into those specifics, I step back to reflect on why Stewart and Peck appear this concerned about a provision that, by most accounts, addresses a technical issue of only modest significance.

The nine DHSs reaching modest significance in the ileum were not near any gene known to be regulated by microbiota (Supplemental Table S7; Rawls et al. 2006 ; Donohoe et al. 2011 ; El Aidy et al. 2012 ; Larsson et al. 2012 ; Pott et al. 2012 ).

Furthermore, there is an interaction between the two CTCF sites flanking the region encompassing both the LCR and the gene cluster, albeit one of modest significance.

It is anticipated that most disease-phenotype associations of complex traits are likely to be of modest significance, with OR <1.5 [ 52 ].

Furthermore, compared with SSCVs identified by juncmut, the variant chosen by SpliceAI 23 , a machine learning-based splicing effect predictor, showed modest significance (Fig. 1e , see “Methods” section for details).

Among the significant factors for overall survival, male gender ( p =0.078), pulmonary parenchymal involvement ( p =0.044) and negative BM ( p =0.080) also had modest significance on multivariate analysis.

Interestingly, however, G114E did rescue docking with modest significance, and notably, D184W elicited a highly significant rescue of BB depth compared to knockdown (Fig. 4F–H ).

Statistical analysis demonstrated that the individual parameters by themselves displayed only modest significance and had low predictive power compared to the pyrexia scores calculated by the proposed algorithm.

Excluding non-significant variables and those with modest significance, patient age, sex, race, marital status, histological classification, and Ann Arbor stage were used as factors to construct the nomogram for OS and DSS in the training dataset.

Given the modest significance of our findings, further research is needed to confirm these suggestive associations.

Across the three comparisons, we observed downregulation of processes related to ‘extracellular matrix organization’ and ‘cell adhesion’, although these terms reached only modest significance in our cohort, likely due to the narrower focus on DT-G1 meningiomas.

The role of structural variables exerts a constructive impact on bridging the financial depth gap, albeit with modest significance.

Tumors with loss of the other miRNAs showed a modest significance for this region (hsa-mir-137; Fig. 6 B ) or no significance (hsa-mir-23b; data not shown).

In BRCA, clustering on all variables yields no significant separation ( P = 0.28), while SPLS and the CCA‐based methods achieve modest significance only when using all 5 components (SPLS: P = ; PMDCCA: P = ; RGCCA: P = ) but fail when restricted to their selected features.

In the genes ABCC9 (LocusLink ID 10060) and LIPC (LocusLink ID 3990), single SNPs of modest significance were associated with disease status in the case control and therefore are not discussed further here.