However, the near-significant association of time to ART initiation with neutralization, while not reaching statistical significance, suggests a potential but less pronounced role of early ART initiation in shaping neutralization responses.
Among comorbidities, AUCs remained low, though in patients with chronic kidney disease, lactate clearance reached an AUC of 0.43 compared to 0.33 for PCTc, with a near-significant p -value of 0.054.
The near-significant difference in cognitive distortions suggests potential clinical relevance, warranting further study with larger samples.
Boxplots for the comparisons of the abundances for taxa with near-significant p values (e.g., 0.063–0.059) are available in Figure S3 .
Nevertheless, an analysis using the last observation caring forward method could largely replicate our results but only at a near-significant level for the impact of childhood trauma on therapy outcome (data on request).
Cyanocobalamin supplemented at 1 μg/mL (750 nM) did not increase the cell number in homocystine-treated HCT116 and MC38 cells ( Figure 1 A,B), and a small near-significant increase in CT26 cells was observed ( Figure 1 C).
Also, as expected, we found near-significant correlations between ICS adherence and ACQ-6, corroborating that taking one’s medication regularly improves asthma control, but the present study might be underpowered to demonstrate proper significance.
Overall, while gender did not significantly affect outcomes in either group, the near-significant result in the intervention arm may warrant further investigation in a larger cohort (Table 5 ).
A similar explanation could be provided for non-verbal IQ being a significant (or near-significant) influencer of internalising symptoms only when communication difficulties were not yet included in the regression ( Table 3 and Table 4 ). 4.3.
In contrast, diabetic participants exhibited a near-significant difference in BMI across tertiles ( P ═ 0.082).
Notably, several core clock genes, including BMAL1 , PER1 , NR1D2 , and CRY1 , showed significant rhythmicity in both sample sets, whereas NR1D1 in adult EPSCs ( p = 0.062) and PER2 in fetal EPSCs ( p = 0.065) exhibited only near-significant oscillatory patterns (Fig. 1C and Supplementary Fig. 1G ).
Interestingly, we found that in addition to causing increases in amino acids that shuttle nitrogen out of tissues (alanine, glutamine, and proline), chronic treatment with tirzepatide also led to near-significant increases in levels of urea cycle intermediates (citrulline and ornithine) in BAT.
We also observed a near-significant correlation for miR-21 expression between primary tumor TAFs and TAFs found in LN metastases.
However, when we minimized the effect of extinction by analyzing a smaller number of trials at the beginning of the test session (5 instead of 10), the near-significant effects disappeared in the unpaired (sham) group, but not the paired group (data not shown).
The near-significant effects of genotype on trials ( Fig. 2C ) and incorrect responses ( Fig. 2D ) to criterion in the full reversal test could be accounted for by retarded egocentric discrimination learning (trials, F 1,30 = 0.64, p = .43; incorrect responses, F 1,30 = 0.57, p = .46).
MAP data was not available in COGENT-BP and UK Biobank, so we also examined the association of an MAP variant of SCGN with SBP, since it was also near-significant for this trait in our discovery sample.
Hybridisation was negatively associated with age but positively correlated with the number of listed plants and their reported uses, while multilingualism showed a near-significant positive trend.
Functional connectivity within DM-SNs In FC analysis with normal ICA / dual-regression procedure, neither significant nor even near-significant group differences were detected on any model order for the DM-SNs.
The near-significant association supports the need for larger prospective studies to confirm this relationship, particularly given the high co-prevalence of both conditions in Chinese pregnant women and the potential clinical implications for targeted supplementation.
However, that was not the case here providing further support that the near-significant trends seen in this study likely reflect real negative effects of these nonstandard diets on body size, weight, and fat composition.
When responding to a psychological stressor, the children in the control group showed a significant increase in cortisol levels, whereas the children in the OCD group showed a near-significant decrease.
55 revealed that linezolid demonstrated statistically significantly higher clinical cure rates when compared with its bactericidal comparators and reported near-significant association of increased mortality in patients treated with tigecycline.
There was a near-significant difference for final sensory with GSW mechanism, resulting in the worst outcomes.
In particular, the observation of significant or near-significant increases in diethyl phthalate and several other phthalate metabolites among adolescents who used cosmetic products; the associations of deodorant/perfume use with diisopentyl phthalate, face/body cream use with benzyl butyl phthalate, and face/body wash use with di-n-hexyl phthalate support the possibility that these compounds may enter the body through product formulations or packaging materials.
While none of the OTUs were statistically significant ( p FDR < 0.05; see Additional file 3 : Table S5a), two out of the three near-significant OTUs ( p FDR < 0.10) in the meta-analysis were also discovered in our original analysis.