“nominally significant”

All nominally significant associations, classified as an uncorrected p < 0.05, are reported in the text. p ‐values were corrected for multiple comparisons for all VEGF predictors across all data types and outcomes using false discovery rate (FDR) procedure, including 615 models.

On chromosome 16p12, nominally significant lod score increases (p ≤ 0.05), up to a lod score of 2.9 in 32 families, were observed with several covariate orderings.

In the PSF2 cross, fully 28.7% (155 of 541) of the loci we mapped exhibited departures from a 1∶1 ratio that were nominally significant at the P = 0.05 level.

The resulting p -values were considered nominally significant at p < 0.05 level.

The nominally significant threshold ( P < .05) was used for alternative mendelian randomization methods.

In brain (ROS/MAP, n = 515), four of 45 CpGs having one or more nearby transcripts were related to nearby gene expression at FDR < 0.05, and 11 (24%) showed nominally significant (p < 0.05) associations with expression ( Supplementary Table 8 ).

In these analyses, 8 of 28 publicly available GWAS summary statistics displayed nominally significant ( P < .05) genetic correlations with TRS, of which 5 survived multiple testing correction (FDER p < 0.05; Figure 4 ; eTable 4 in Supplement 1 ).

In our phenome-wide analysis, we identified a total of 179 nominally significant associations ( p < 0.05; Fig. 1 , Supplemental Table 5 ) with respect to TTR Ala81Thr, His90Asn, and Val122Ile mutations (60, 54, and 65 associations, respectively).

However, 38,797 probes were nominally significant (at p < 0.05) in the caudate and 35,622 probes in the ACC - Fig. 1 and Supplementary File 1 .

A strong correlation (|r|≥ 0.80) between the gene expression and DNA methylation profiles was observed at 27% of loci (166 CpGs in 153 genes) in HCT116 cells, out of them, 47 CpGs corresponding to 44 genes were nominally significant ( p < 0.05) ( Supplementary Table 3 ) indicating that observed hypermethylations affect cellular function by altering gene expression in cancer cell lines.

Genetic causal relationships across 21 digestive disorders Among 91 pairs of the 14 disorders with significant heritability, 64 pairs showed positive genetic correlation with Bonferroni correction (p ≤ 0.05/91), and the other 18 pairs had nominally significant genetic correlations (p ≤ 0.05), indicating considerable genetic basis of complex relationships among these disorders ( Figure 3 A; Table S5 ).

Excess significance test was used to investigate whether the observed number of studies (O) with nominally significant results (‘positive’ studies, p<0.05) was larger than the expected number of significant results (E).

In addition, nominally significant differences (ie, P < 0.05) between groups were obtained in secondary analyses comparing the treatment groups with respect to measures of pain interference with function and sleep using items from the BPI interference question.

Very little epistasis was apparentin the hotspot regions, with less than 7% of trans methQTL in these hotspots possessing a nominally significant (P<0.05) epistatic interaction, and less than 1%of trans methQTLwith a significant epistatic interaction(see Supplementary Table 3 ).

Because we detected a nominally significant difference (p = 0.05) in the amount of fruit consumed by the members of Mica's group (7.9%, 95% CI: 0.0–8.3%) and the members of Viola's group (2.2%, 95% CI: 1.0–7.3%) during the sampling period, we also compared our results to a published data set of seasonal differences in gut microbiome composition in humans ( Davenport et al., 2014 ).

While some numerical differences existed in the proportions of patients who underwent open vs laparoscopic surgery across the four warming treatment arms, this difference was not found to be nominally significant (P > 0.05) on post-hoc testing of the distribution using a chi-squared test.

Using this approach, JoineRML identified 10 proteins with nominally significant association with the disease risk (Wald test p < 0.05), of which two had measurements from at least five individuals in both classes and AUROC >0.75 in at least the two last evaluation points (Figure 4a ).

We also observed nominally significant (p < 0.05) single SNP associations at several other SNPs in PGIS .

A model consisting of 15 previous SNPs that also showed nominally significant associations ( p < 0.05) in this Korean study did not achieve sufficient predictability for DCVD (AUC, 53.7%).

SNPs associated with LDL-C and CAD 84 of the 2966 LDL-C associated SNPs (25 of 172 loci) had nominally significant associations (at P < 0.05) with CAD risk in CARDIoGRAMplusC4D (including 63,746 cases and 130,681 controls of European ancestry) (Supplementary Fig. 1) (Consortium et al. 2013 ).

If the MR analysis results were nominally significant ( P < 0.05), we considered that there might be a causal relationship between the intestinal flora and the lipids.

For this purpose, nominally significant (p < 0.05) TWMR effects were retained and their direction was compared to the direction of the probe with the smallest nominally significant p value (p < 0.05) in the mirror association model for the corresponding gene ( ± 10 kb) and trait.

There was predominantly a candidate gene approach using common alleles, which despite small sample sizes (median 93 [IQR 40–222]) with no trend to an increase over time, generated a high proportion (74.5%) of nominally significant (p<0.05) reported associations suggesting the possibility of significance-chasing bias.

Of these, 11 (4.4%) had nominally significant association (p-value < 0.05) with TNFα receptor 2 levels.

For CD4 + T cells, baseline β7 integrin expression had a nominally significant (unadjusted p < 0.05) effect on the following genes: ITGA4, GATA3, GZMA, BATF, HIFA, ICOS and IRF4, although none of these genes had an FDR below 0.1.