“nominally significant”

Genes with nominally significant differential expression ( p < 0.05) between the chronic and acute time points in untreated or P. gingivalis - or C. pneumoniae -treated ApoE -/- mice are tabulated in Figure 3 .

In addition, the ovarian cancer patients had a nominally significant decrease in the number of 12 and 22 genotype carriers compared to the controls (p = 0.05) suggesting that the duplication may be protective for the disease with an odds ratio of 0.72 (95% CI, 0.53–0.99).

Where the linear dose term was nominally significant at P<0.05, we also used a complementary means of analysis to examine within-subject QTc effects.

For any nominally significant findings ( P <0.05) in the sex‐specific end points, a post hoc hypothesis test was performed to evaluate whether the MR estimates between the male and female end point were significantly different ( P value <0.05) from each other.

No significant PRS-by-environment interactions were observed after accounting for multiple comparisons, but alcohol consumption and physical activity had nominally significant interaction terms with PRS ( p -value < 0.05). 4.

To determine CNV enrichment, we only considered loci that were nominally significant between the comparative groups ( P < 0.05).

Nominally significant positive correlations (p < 0.05) were observed in kidney, liver, lung and muscle (Supplementary Fig. 6D-G).

Survival Pre-HSCT weight, BMI, fat mass, RAPA-Aerobic activity score, Positive Affect, GCGQ score, and ASAS-Wellness all correlated with longer survival; however, these were nominally significant ( p < 0.05) and did not reach significance at our pre-determined level ( p < 0.01).

Very little epistasis was apparentin the hotspot regions, with less than 7% of trans methQTL in these hotspots possessing a nominally significant (P<0.05) epistatic interaction, and less than 1%of trans methQTLwith a significant epistatic interaction(see Supplementary Table 3 ).

Smoothed methylation values over nominally significant ( p < 0.05) DMRs from each comparison were obtained using the “getMeth” function in the bsseq R package v1.36.0.

Nominally significant associations with p < 0.05 were also reported.

In these analyses, 8 of 28 publicly available GWAS summary statistics displayed nominally significant ( P < .05) genetic correlations with TRS, of which 5 survived multiple testing correction (FDER p < 0.05; Figure 4 ; eTable 4 in Supplement 1 ).

All nominally significant associations, classified as an uncorrected p < 0.05, are reported in the text. p ‐values were corrected for multiple comparisons for all VEGF predictors across all data types and outcomes using false discovery rate (FDR) procedure, including 615 models.

In the PSF2 cross, fully 28.7% (155 of 541) of the loci we mapped exhibited departures from a 1∶1 ratio that were nominally significant at the P = 0.05 level.

The resulting p -values were considered nominally significant at p < 0.05 level.

The nominally significant threshold ( P < .05) was used for alternative mendelian randomization methods.

As shown in Table 2 , although in our GWAS none of the two SOX6 gene SNPs achieved nominally significant p values ( p <0.05) for univariate association with BMI, FM or hip BMD, both SNPs achieved p values of 10 −6 to 10 −7 for bivariate association with BMI-hip BMD or FM-hip BMD.

In brain (ROS/MAP, n = 515), four of 45 CpGs having one or more nearby transcripts were related to nearby gene expression at FDR < 0.05, and 11 (24%) showed nominally significant (p < 0.05) associations with expression ( Supplementary Table 8 ).

In addition, nominally significant differences (ie, P < 0.05) between groups were obtained in secondary analyses comparing the treatment groups with respect to measures of pain interference with function and sleep using items from the BPI interference question.

A strong correlation (|r|≥ 0.80) between the gene expression and DNA methylation profiles was observed at 27% of loci (166 CpGs in 153 genes) in HCT116 cells, out of them, 47 CpGs corresponding to 44 genes were nominally significant ( p < 0.05) ( Supplementary Table 3 ) indicating that observed hypermethylations affect cellular function by altering gene expression in cancer cell lines.

Cg25212453 (model C) was surrounded by 13 other CpGs, of which three were nominally significant ( P values < 0.05).

If the MR analysis results were nominally significant ( P < 0.05), we considered that there might be a causal relationship between the intestinal flora and the lipids.

Using this approach, JoineRML identified 10 proteins with nominally significant association with the disease risk (Wald test p < 0.05), of which two had measurements from at least five individuals in both classes and AUROC >0.75 in at least the two last evaluation points (Figure 4a ).

Then, associations between alcohol dependence and all nominally significant SNPs (p<0.05 in AAs) in PHF3-PTP4A1 were retested in EAs.

A subset of 80/233 (34.3%) FDR significant associations also were nominally significant in at least one population of non-European ancestry ( p value <0.05; Supplementary Data 13 , 14 ).