“nominally significant”

Of these, 10 had significantly different effect sizes ( p -value < 7.8 × 10 −4 , Bonferroni correction for 64 variants) and 22 were nominally significant ( p -value < 0.05).

Gene-based analysis revealed 76 nominally significant ( p ≤ 0.050) longevity-associated genes, and we call these 76 genes the “longevity-associated gene set” (Tables S3 and S4 ).

We reported genetic associations that were nominally significant ( P < 0.05) and directionally consistent with observational findings.

Specifically, we identified a total of 169 nominally significant enriched terms ( p -value < 0.05 and FDR < 0.2), which represent a medium-confidence set, including a subset of 37 high-confidence terms that passed multiple test correction with an FDR of <0.05 ( Figure 3 ).

In addition, there was substantial enrichment of nominally significant associations ( p <0.05) among disease SNPs.

To verify the reliability of these polygenic associations, we repeated the analyses using PRS comprising only the 108 sentinel genome-wide significant schizophrenia variants 15 , based on the assumption that the effect size estimates of genome-wide significant variants should be less affected by population structure than non-significant variants; 77 of the 104 associated traits were nominally significant ( P < 0.05) based on the PRS comprising only genome-wide significant variants.

Comparison of miRNA profiles between low- and high-risk tumors identified multiple candidate miRNAs with nominally significant differential expression ( p < 0.05).

Multivariable modelling and the relations between predictor variables All predictor variables having shown nominally significant (p < 0.05) effects on hand preference in univariable testing (i.e. all but maternal smoking) were then included in the multivariable analysis, using general linear modelling (Methods), with hand preference as the dependent variable.

While none of the GO terms from the trio univariate GSEA met the FDR significance threshold, nominally significant (p < 0.05) pathways suggest some overlap with Cohort 1 results, including neuron recognition , cerebral cortex cell migration and axonal fasciculation and GO terms related to.

Variable Selection Based on linear mixed models including the factors of time, age at enrollment, sex, and stimulus version, 23 speech variables from the picture description task showed nominally significant ( P < 0.05) effects of time at the group level.

In a per-protein analysis, replacing values below the limit of detection with protein specific LOD-values, five proteins (CSF-1, NTRK3, ICOSLG, SCF and PECAM-1) were found to have nominally significant differences between the two time-points (p < 0.05, Wilcox test).

Secondly, we estimated genetic correlations between each of the traits with nominally significant (p<0.05) univariate values.

We note that although APOE has previously been identified as a AD TWAS gene in microglia 83 , we did not highlight it in our scTWAS results because it did not pass Stage 1 screening, despite nominally significant Stage 2 associations in proliferate, surveilling, and reacting microglia (nominal p -values < 0.05).

If such interaction was nominally significant ( P < 0.05), the analysis was conducted separately in cases and control subjects (eg, after stratifying by asthma).

Although 75 proteins showed nominally significant abundance differences ( p ≤ 0.05), all corresponding q‐values were 0.99, indicating no statistically robust differences in abundance between PEA and VC at 36 h.

Of those, 38,776 (95%) showed the same direction of effect, 33,128 (81%) also had a nominally significant p value ( p < 0.05), and 25,544 (63%) had an FDR-adjusted p < 0.05 in the BLUEPRINT data (Fig. 1b , Supplementary Data 1 ).

So it should be kept in mind that each individual p value has a one-in-twenty chance of being nominally significant (p < 0.05) purely from random fluctuations.

We found 92 (53 increased and 39 decreased) nominally significant DEGs of KRAS mut with a p -value < 0.05, which FREM1 , ERMP1 (up-regulated), and CCL8 (down-regulated) were significant after multiple test corrections (FDR < 0.05).

Differential methylation analysis identified 6095 nominally significant differentially methylated CpG sites (DMCs; p < 0.05, log fold-change > 0.1), associated with 2935 unique genes.

IL‐1b and IL‐4 showed a trend toward being higher in serum in the high IFN patients as compared with the low IFN SLE patients (nominally significant P < 0.05 for both).

A FDR-adjusted P value < 0.05 was considered statistically significant; unadjusted P value < 0.05 was considered nominally significant and unadjusted P value = 0.05 was considered borderline significant.

Fourteen MGSs were nominally significant for the broad spectrum (Wilcoxon signed-rank test, unadjusted p < 0.05).

A total of 7 SNPs (related to genes FNTB, MVD, PDSS1, and PDSS2) showed a nominally significant association ( p < 0.05) with the BP-induced change in spine BMD, whereas 15 SNPs (in FDPS, FNTA, FNTB, IDI1, MVD, MVK, PDSS1, and PDSS2 genes) were associated with hip BMD changes ( Table 2 ).

Of these, 12 were nominally significant at P < 0.05 and none were nominally significant at P < 0.01 (Table 3 ).

Each of the independent variables in the regression models was nominally significant, with p < 0.05.