“nominally significant”

Each of the independent variables in the regression models was nominally significant, with p < 0.05.

As shown in Table 1 , results of the Gene ontology term enrichment analysis revealed 14 nominally significant (uncorrected p <0 .05) associations, but only the mitochondrion GO:0005739 (Benjamini Hochberg p adj = 0.002) survived correction for multiple testing.

We test what happens if we select as targets sets of genes that are both within a pathway or a network module that is itself significantly enriched for genetic association to a disease as measured by a GWAS (based on a Pascal gene score threshold) and have a nominally significant (P < 0.05) Pascal gene score to the same disease in the same GWAS.

The conditional analysis shows that 45 (including 42 genes) out of the total 74 (~60.8%) unique associations are still nominally significant when conditioned on known GWAS variants ( p < 0.05, Supplementary Table S4 ).

Additionally, for each of the 594 eGFR signals, we queried further genetic association data relevant to the kidney researcher: (7) To highlight the relevance of a genetic association with creatinine-based eGFR for kidney function rather than creatinine metabolism, we included information on whether the locus association was directionally consistent and nominally significant for blood urea nitrogen (BUN) or cystatin-based eGFR (eGFRcys; i.e. locus lead variant P < 0.05; opposite or same direction of effect for BUN or eGFRcys, respectively; n = 852,678 or 460,826, respectively; yielding 491 of 594 signals validated); (8) Since genetic effects with steeper decline versus more stable eGFR over time might point to particularly deleterious mechanisms for the kidney, we included information on whether the signal showed significant association on eGFR decline (N = 343,339 [ 25 ], yielding 8 decline signals).

Six miRNAs were nominally significant ( p < 0.05) in VDAART and three were present in Project Viva.

To determine if any annotations were enriched in both mouse and human, even though individual genes were not shared, separate lists of genes nominally significant in human (915 genes p ≤ 0.05) and human homologues of the 42 mouse genes with p ≤ 0.05 were entered into DAVID.

The top SNP, located in the DET1 gene, was nominally significant (p<0.05) but did not withstand correction for multiple testing (p = 0.42).

According to BADGERS, the reference panel comprises 1738 traits from the UKB 17 , selected on the basis of nominally significant SNP-based heritability ( P < 0.05).

Despite our large sample size, AgeAccelENCen40 + exhibits only nominally significant associations with educational level, income, and handgrip strength ( p < 0.05, Supplementary Fig.

We found nominally significant correlations between nausea (SSQ) and Path-Choice (r s = 0.26, p < 0.05), between sensory fidelity (PQ3) and Path-Choice (r s = 0.30, p < 0.05), between interface quality (PQ3) and Fishing (r s = 0.26, p < 0.05), and between somatic concerns (ASI) and Fishing (r s = 0.26, p < 0.05), but none survived correction for multiple testing.

Only behavioral measures showing a nominally significant association ( p < 0.05) with the same PRS factor in all three analytical scenarios (primary, updated GWAS, and PRS‐CS) were carried forward to the mediation analysis.

We identified 368 SNPs at this stage that were nominally significant (P < 0.05) in the combined stage analysis, suggesting association with pulmonary TB in the Indonesian population.

Evidence of 22 (51%) non‐genetic biomarkers exhibited a nominally significant effect ( p < 0.05) on AS, and 7 associations (14%) showed small‐study effects.

For associations with infections, we visualized the results of all allelic associations which had at least nominally significant p-values (P ≤ 0.05) with at least one infection category or with the “any infection” phenotype.

Three of these loci also showed at least nominally significant association ( p < 0.05) with a longitudinal change in EM performance ( Table 2 A), with effects pointing in the same direction in all instances.

Markers with nominally significant p-values in one or more cell populations ( P ≤ 0.05; e.g CD39, CD38, Ki-67, PD-1) were visualized in boxplots; statistical significance computed using the linear mixed model were further confirmed using non-parametric Wilcoxon rank sum test.

Further, based on the nominally significant (single CpG site p -value < 0.05) CpGs within each of the DMRs, there was a general trend towards consistent association directions with increasing BTEX exposure for the DMRs.

Nominally significant ( p < 0.05) negative association was seen between PRS SCZ and EY in the NPSYCH group, but not in the PSYCH group (Fig. 3b ).

The criteria for a highly suggestive association were met if: P < 10 −6 , >1000 participants, and largest study in the meta-analysis presenting nominally significant estimate (i.e., P < 0.05).

A total of 110 of 176 (63%) were nominally significant ( P < 0.05), and all but one had concordant direction of effect.

Three further SNP‘s showed nominally significant interactions ( p < 0.05).

When using cutoff value 0.05 to separate the genes into three gene sets (i.e., nominally significant genes were defined as those with gene-wise P value < 0.05), we found that the DEPgenes in the subnetwork had a significantly larger proportion of nominally significant genes in the GWAS dataset (Fisher's exact test, P = 4.13 × 10 -4 ) compared to the remaining genes.

Of the 118 disease signatures tested, 12 showed a nominally significant association ( p < 0.05) with at least one of the three dichotomized PCS scores (Table 2 ).

Given the possibility that the observed lack of correlation for LDL-C could be due to reduced power from a limited number of variants attaining a suggestive p -value (<5 × 10 −07 ), we repeated the analysis with a subset of 122 nominally significant ( p -value < 0.05) LDL-C associated variants in this locus.