“nominally significant”

We report nominally significant associations at the P ≤ 0.05 level.

To determine if any annotations were enriched in both mouse and human, even though individual genes were not shared, separate lists of genes nominally significant in human (915 genes p ≤ 0.05) and human homologues of the 42 mouse genes with p ≤ 0.05 were entered into DAVID.

Nine (35%) reported nominally significant summary results at P < 0.05 (2 had P < 0.001).

To calculate the excess of nominally significant ( p < 0.05) lipids for the different main effects and interactions, permutation test was performed.

The criteria for a highly suggestive association were met if: P < 10 −6 , >1000 participants, and largest study in the meta-analysis presenting nominally significant estimate (i.e., P < 0.05).

Other effective measures include a count of significant genes [ 6 , 9 ], the ratio of nominally significant (P < 0.05) to non-significant SNPs [ 10 ], max mean and re-standardization of gene measures [ 7 ].

A total of 110 of 176 (63%) were nominally significant ( P < 0.05), and all but one had concordant direction of effect.

Markers with nominally significant p-values in one or more cell populations ( P ≤ 0.05; e.g CD39, CD38, Ki-67, PD-1) were visualized in boxplots; statistical significance computed using the linear mixed model were further confirmed using non-parametric Wilcoxon rank sum test.

Interestingly, the two nominally significant CpG sites ( P < 0.05) that overlap between the cannabis-only and the cannabis with tobacco data are located within the MARC2 and CUX1 genes, which both have reported roles in brain function; a SNP in MARC2 has been provisionally associated with the biological response to antipsychotic therapy in schizophrenia patients 77 , and the CUX1 gene has an established role in neural development 78 .

When using cutoff value 0.05 to separate the genes into three gene sets (i.e., nominally significant genes were defined as those with gene-wise P value < 0.05), we found that the DEPgenes in the subnetwork had a significantly larger proportion of nominally significant genes in the GWAS dataset (Fisher's exact test, P = 4.13 × 10 -4 ) compared to the remaining genes.

Nominally significant association (P<0.05) was observed for markers in: TCF7L2, RBMS1, CDKAL1, ZNF239, KCNQ1 and TCF1 and a significant bias (P<0.05) towards OR>1 was observed for markers selected from previous T2D genome-wide association studies, consistent with a role for Old World variants in susceptibility to T2D in Latin Americans.

Nominally significant ( p < 0.05) negative association was seen between PRS SCZ and EY in the NPSYCH group, but not in the PSYCH group (Fig. 3b ).

We performed a test for excess significance to evaluate whether the number of studies reporting nominally significant results ( p -value < 0.05) is greater compared to their expected number [ 24 , 25 ].

Nominally significant associations ( p < 0.05) were observed for obesity, BMI, dementia, asthma, COPD/asthma-related infections, and serum urate ( Table S20 ).

While these results were nominally significant (p < 0.05), they did not maintain statistical significance after Hochberg correction.

Sex-specific SI Trends during Growth The interaction effect of categorical age (<6 or ≥6 years) and sex on SI was nominally significant ( p = 0.05).

Above this, in the validation cohort, associations between increasing kynurenine or the kynurenine/tryptophan ratio with decreasing LVEF were nominally significant ( p < 0.05), but failed the correction for multiple testing (FDR > 0.05).

Of the 204 primary meta-analyses performed, nominally significant associations ( P < 0.05) with the risk of sepsis were found with 26 (34%) variants of 21 genes for at least one genetic model containing TLR1 rs5743551-7202A/G; LBP rs2232618 Phe436Leu; the MBL2 A/O haplotype; RAGE rs1800625-429 T/C and rs1800624-374 T/A; NOD2 rs2066844 Arg702Trp and rs2066847 Leu1

Briefly, drugs were ranked by their frequency of being at least nominally significant ( p < 0.05) across the four time windows and eight models ( Table 4 ).

23 We specifically identified outcomes for which meta-analyses of observational studies showed nominally significant associations (at P≤0.05), did not have large between study heterogeneity, were based on evidence from more than 500 cases (or more than 5000 total participants if the type of metric was continuous), and showed no evidence of small study effects or excess significance.

Results Allelic associations The European Caucasian sample set revealed nominally significant ( P <0.05) associations with gout at two block-3 SNPs: rs475688 and rs7932775 (SLC22A12; OR = 1.26, P = 0.043; OR = 1.32, P = 0.033, respectively) (Table 1 ).

Fourth, a nominally significant association (p-value < 0.05) was considered “weak” evidence.

We identified several nominally significant ( P < 0.05) causal dietary factors associated with mvPuberty status, with oily fish intake (β = −0.11, P = 6.55 × 10 −3 ) and the serum retinol level (β = −0.18, P = 4.49 × 10 −4 ) surpassing the Bonferroni-corrected threshold for multiple comparisons (Table 3 ).

Differentially abundant proteins in each group were defined based on the following criteria: Proteins identified in at least 60% of samples in at least one group and nominally significant difference in protein abundance (unadjusted p < 0.05).

Given the possibility that the observed lack of correlation for LDL-C could be due to reduced power from a limited number of variants attaining a suggestive p -value (<5 × 10 −07 ), we repeated the analysis with a subset of 122 nominally significant ( p -value < 0.05) LDL-C associated variants in this locus.