“nominally significant”

Step 5: We generate a ranked list of drug repositioning candidates and MOA categories that show enrichment of nominally significant ( p < 0.05) gene-based associations (MAGMA and S-PrediXcan) across compounds within each category.

Overall, nine of the 11 of the outcomes reported nominally significant summary results ( p < 0.05), with 4 associations surviving the application of the more stringent p value ( p < 10 −6 ).

As an exploratory study, we also indicated associations that are nominally significant with a P-value <0.05.

Using these phenotypes, we computed the odds ratio of the proportion of nominally significant ( p < 0.05) hits in the EPAS1 gene region (chr2:46,150,000–46,450,000) encompassing our regulatory elements compared with variants in a randomly selected matched window.

None of these were nominally significant in the full UKBB dataset ( p -value > 0.05).

Among these, 267 were nominally significant at p < 0.05, of which 87 related to FODMAPs, 71 to gluten and 109 to placebo, i.e. with no enrichment of associations to treatment groups vs placebo.

Multi-omics analyses revealed nominally significant associations with specific gut microbes (e.g., Lactobacillus), inflammatory proteins (TNFSF12, CXCL5), immunophenotypes, and plasma metabolites (all P <.05).

∗Nominally significant ( P < 0.05).

Of the 12 haplotypes with P < 10 -6 in GS:SFHS, none were nominally significant ( P ≥ 0.05) in ELSA.

Among complete blood count, red cell distribution width, PLT, and PCT showed nominally significant pre–post differences ( P < .05).

To be included as a training feature in the outer loop, we required that a given functional connection exhibit at least one nominally significant behavioral correlation ( p < .05) across all folds of the inner loop.

We found nominally significant correlations between nausea (SSQ) and Path-Choice (r s = 0.26, p < 0.05), between sensory fidelity (PQ3) and Path-Choice (r s = 0.30, p < 0.05), between interface quality (PQ3) and Fishing (r s = 0.26, p < 0.05), and between somatic concerns (ASI) and Fishing (r s = 0.26, p < 0.05), but none survived correction for multiple testing.

Eleven were nominally significant for ADFI ( P < 0.05) and two were significant after Bonferroni correction.

Ninety-four proteins were nominally significant ( p < 0.05), yet none survived FDR-correction.

The enrichment for the nominally significant association ( p < 0.05) was evaluated by a 10,000‐permutation test.

When the Saline Solution group was compared with the remaining groups, the mean difference was 0.96667 versus SP Gel ( p = 0.474) and 3.17333 versus SP Macerate (standard error = 1.39615; p = 0.031), with the latter representing the only nominally significant difference ( p < 0.05).

Larger magnitude nominally significant (p<0.05) genetic correlations were also found with depression-related phenotypes (range of r g 0.46–0.52), self-reported osteoarthritis ( r g = 0.63), and ICD-10-defined osteoarthritis ( r g = 0.49) phenotypes.

In subsequent analyses stratified by genotype, we observed nominally significant associations in both homozygous major and homozygous minor allele carriers ( p < 0.05).

After multiple testing corrections, one of these SNPs was significant (rs73349121, p = 0.0001), 9 were nominally significant ( p < 0.05, with 5 expected), and 58/99 had a direction of effect that was consistent with the Whites-only analyses (one-sided p = 0.04, Fig. 2 ).

However, nominally significant ( p < 0.05) associations were found for 15 pairs, 14 of which involved small or very small VLDLs and CpG sites in either SREBF1 or CPT1A .

A further 142 had a false discovery rate (FDR) < 0.05 and 192 were nominally significant at P < 0.05 ( Supplementary Table 2 ).

Only the sociability and rs-fMRI trait pairs showing at least nominally significant ( p < 0.05) global, bivariate genetic correlations were further explored at the local genomic level.

BNC2 rs10756819 was not genome-wide significant but showed a consistent and nominally significant effect in all studied cohorts ( p value <0.05); this therefore replicated our previous finding from a candidate gene study (Jacobs et al. 2012 ) suggesting that BNC2 influences subtle variation in skin color.

However, in the subsample of AN restricting patients only, the SCZ PGS showed a nominally significant (i.e., p < 0.05) negative association with the CIA score.

Of these 20 metabolites, only five showed nominally significant univariate differences between ME/CFS cases and controls (indole-3-propionic acid, aminomalonate, ornithine, leucine, and succinic acid; all p < 0.05), while the majority—including proline and indole-3-lactate, the constituents of the top-ranked interaction term—did not reach univariate significance in isolation ( p = 0.777 and p = 0.237, respectively).