“nominally significant”

We performed over-/under-representation analysis of GO themes in the genes where the RBP plus model was nominally significant (p < 0.05), using uncorrected p-values for GO analysis to reduce the false negative rate of a stricter FDR-based threshold.

We found that 18 of the 108 proteins investigated were influenced by storage time (Supplementary Table 1, nominally significant, p < 0.05), and one protein (Cancer antigen 125; CA-125 also known as Mucin 16) remained statistically significant after correction for testing of multiple hypotheses (Bonferroni, p < 0.05/108 = 4.6 × 10 − 4 ).

Seventy CpGs (in 41 genes) showed nominally significant associations ( P < 0.05) with AD-ND codependence in both AAs and EAs.

CMR LV phenotypes all showed nominally significant evidence of heritability ( P -value < 0.05), with LV end diastolic volume index showing the strongest evidence (h 2 QTDT , 42 ± 10%; h 2 IBS>0.05 , 47 ± 12%).

As an exploratory study, we also indicated associations that are nominally significant with a P-value <0.05.

To be included as a training feature in the outer loop, we required that a given functional connection exhibit at least one nominally significant behavioral correlation ( p < .05) across all folds of the inner loop.

However, in the subsample of AN restricting patients only, the SCZ PGS showed a nominally significant (i.e., p < 0.05) negative association with the CIA score.

Epigenome-wide association study of Frailty Index Testing 723,029 lsBINs in 50 FI discordant MZ twin pairs (Gr1) implementing paired t tests revealed overall N D = 27,485 bins that showed nominally significant associations ( P < 0.05), and of these, the top 20 association signals were ranged P = 7.01 −5 to 2.17 −6 .

Moderate certainty was assigned when the effect size was more than 5% and all other criteria were met, while low certainty was assigned to associations that were nominally significant ( P < 0.05) but did not satisfy the thresholds for high or moderate certainty.

Of the 66 significant loci in the European Caucasian meta-analysis, 56 were nominally significant ( P < 0.05), and 37 after Bonferroni correction ( P < 7.6e-04) in the meta-analyzed replication cohort.

Among complete blood count, red cell distribution width, PLT, and PCT showed nominally significant pre–post differences ( P < .05).

Clinical Characteristics of Patients with Upper-Limb Melanoma ( Table 4 ) As illustrated in Table 4 , when comparing nine melanoma patients with upper-limb tumors with the remaining 124 melanoma patients, the only nominally significant findings were a higher frequency of the CT heterozygous genotype (OR = 5.01, p = 0.050) and a lower frequency of the CC homozygous genotype (OR = 0.11, p = 0.040).

None of these were nominally significant in the full UKBB dataset ( p -value > 0.05).

For all nominally significant associations ( p < 0.05), effect sizes were strongly correlated when using imputed vs.

In subsequent analyses stratified by genotype, we observed nominally significant associations in both homozygous major and homozygous minor allele carriers ( p < 0.05).

Step 5: We generate a ranked list of drug repositioning candidates and MOA categories that show enrichment of nominally significant ( p < 0.05) gene-based associations (MAGMA and S-PrediXcan) across compounds within each category.

Since the primary endpoints in both trials did not reach statistical significance, all other p-values <0.05 for both predefined subgroups and post hoc analyses are considered nominally significant and hypothesis-generating.

We performed the association analyses with FG, FI, HOMA-B, HOMA-IR and BMI SDS for the 42 variants, assuming an additive genetic model implemented in linear regression and detected nominally significant associations ( P < 0.05) at eight FG, eight T2D and two FI loci with the phenotypes tested (Material and Methods, Supplementary Material, Table S1 ).

Exploratory analyses and results are also presented for PCA metabolite factors that were nominally significant (unadjusted for multiple comparisons p < 0.05) in the discovery correlation analyses.

The association remained nominally significant in the T2D-unadjusted and case subject-only analyses ( P < 0.05 for both).

Gene-based association signals of genes that showed significant associations with CAD ( P < 2.72 × 10 − 6 ) were compared to that of nominally significant genes related to plasma lipid levels ( P < 0.05, Fig. 4 ).

However, nominally significant ( p < 0.05) associations were found for 15 pairs, 14 of which involved small or very small VLDLs and CpG sites in either SREBF1 or CPT1A .

In mediation analyses, nine metabolites and five plasma proteins showed nominally significant mediation effects in the SGLT2–DR pathway (uncorrected P < 0.05; Supplementary Table S16 ).

Eleven SNPs had ORs >1, and 5 from ADAMTS9 , WFS1 , CDKAL1 , JAZF1 , and TCF7L2 trended or had nominally significant evidence of T2D association ( P < 0.05).

To reduce the multiple testing burden, candidate TFs were tested for interaction with a given gene only if their marginal association with the target probe set was nominally significant ( p <0.05).