“nominally significant”

Step 5: We generate a ranked list of drug repositioning candidates and MOA categories that show enrichment of nominally significant ( p < 0.05) gene-based associations (MAGMA and S-PrediXcan) across compounds within each category.

However, the ADL scale had a nominally significant ( p ‐value <0.05) association with total cerebellar volume and cervical spinal cord CSA (Table S4 ).

This effect was nominally significant (p < 0.05) for four of the eight fingers tested: left 2 nd finger, left 5 th finger, right 2 nd finger, and right 4 th finger ( Table 2 ).

As an exploratory study, we also indicated associations that are nominally significant with a P-value <0.05.

To be included as a training feature in the outer loop, we required that a given functional connection exhibit at least one nominally significant behavioral correlation ( p < .05) across all folds of the inner loop.

At a nominally significant level (P<0.05) only three loci were associated with vertebral fracture and all 14 BMD loci were associated with non-vertebral fracture , but these difference in effects between fracture sites were not significant.

None of these were nominally significant in the full UKBB dataset ( p -value > 0.05).

Among complete blood count, red cell distribution width, PLT, and PCT showed nominally significant pre–post differences ( P < .05).

Epigenome-wide association study of Frailty Index Testing 723,029 lsBINs in 50 FI discordant MZ twin pairs (Gr1) implementing paired t tests revealed overall N D = 27,485 bins that showed nominally significant associations ( P < 0.05), and of these, the top 20 association signals were ranged P = 7.01 −5 to 2.17 −6 .

To verify the reliability of these polygenic associations, we repeated the analyses using PRS comprising only the 108 sentinel genome-wide significant schizophrenia variants 15 , based on the assumption that the effect size estimates of genome-wide significant variants should be less affected by population structure than non-significant variants; 77 of the 104 associated traits were nominally significant ( P < 0.05) based on the PRS comprising only genome-wide significant variants.

However, nominally significant ( p < 0.05) associations were found for 15 pairs, 14 of which involved small or very small VLDLs and CpG sites in either SREBF1 or CPT1A .

Larger magnitude nominally significant (p<0.05) genetic correlations were also found with depression-related phenotypes (range of r g 0.46–0.52), self-reported osteoarthritis ( r g = 0.63), and ICD-10-defined osteoarthritis ( r g = 0.49) phenotypes.

The enrichment for the nominally significant association ( p < 0.05) was evaluated by a 10,000‐permutation test.

A total of 1587 SNPs showed a nominally significant association with ESCC ( p < 0.05 and 95% CI did not include OR = 1).

SNPs associated with LDL-C and CAD 84 of the 2966 LDL-C associated SNPs (25 of 172 loci) had nominally significant associations (at P < 0.05) with CAD risk in CARDIoGRAMplusC4D (including 63,746 cases and 130,681 controls of European ancestry) (Supplementary Fig. 1) (Consortium et al. 2013 ).

To reduce the multiple testing burden, candidate TFs were tested for interaction with a given gene only if their marginal association with the target probe set was nominally significant ( p <0.05).

Of the 245 UKB associations (226 previously reported + 19 previously unreported associations), we find that 72% (176) show at least nominally significant ( p < 0.05 ) age-specific effects within UK women ( Figure 2 C). 37 of these 176 associations, representing 15% of all associations, have a slope with a genome-wide significant p value ( p < 5 × 10 − 8 ), constituting a more stringent criterion (strong and moderate evidence in Figure 2C).

We did not identify any metabolites significantly related in the meta-analysis to any of the four traits (FDR < 0.05) where there was even a nominally significant association (uncorrected P < 0.05) in African-Americans where the effect estimate was in the opposite direction. 3.

In subsequent analyses stratified by genotype, we observed nominally significant associations in both homozygous major and homozygous minor allele carriers ( p < 0.05).

To avoid complex causality relationships, we excluded the results that showed a nominally significant MR estimate in the other direction ( P < 0.05).

Excess significance test was used to investigate whether the observed number of studies (O) with nominally significant results (‘positive’ studies, p<0.05) was larger than the expected number of significant results (E).

In cases of sample overlap and nominally significant results ( P -value < 0.05), we employed MRlap[ 47 ], a recently developed tool to account for potential sample overlap in univariable MR studies.

Among these results, we identified three additional genes with nominally significant differential expression ( P < 0.05) in both the qPCR study and BA10 microarray data as well as a consistent direction of effect (GRM5, NSF, SNCA, Fig. 3 ).

Of these 20 metabolites, only five showed nominally significant univariate differences between ME/CFS cases and controls (indole-3-propionic acid, aminomalonate, ornithine, leucine, and succinic acid; all p < 0.05), while the majority—including proline and indole-3-lactate, the constituents of the top-ranked interaction term—did not reach univariate significance in isolation ( p = 0.777 and p = 0.237, respectively).

Lastly, we classified the sex-mQTLs with FDR-adjusted P diff < 0.05 into one of the following three categories: (i) concordant effect: association found to be FDR-significant in one sex and nominally significant ( P < 0.05) or FDR-significant in the other sex with a consistent effect direction but different magnitude; FDR-adjusted P diff < 0.05.