In addition, very recent meta-analysis, paradoxically, showed a significant increase in the risk of myocardial infarction and an increase in cardiovascular death of borderline significance with rosiglitazone, a member of PPAR γ agonists that is widely used as antidiabetic agent [ 49 ].
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“of borderline significance”
In the literature
The difference among the groups with respect to AUC 0–∞ was of borderline significance, with a mean ratio of 0.77.
Since prior studies had reported that GDMT utilization was related to patient age, 5 , 6 , 14 , 19 we also considered age as a continuous rather than dichotomous variable and found that increasing age had only a modest impact of borderline significance on optimal GDMT utilization.
The Hoorn study, conducted in an older Caucasian population, found that known diabetes was associated with PAD, while newly diagnosed diabetes was of borderline significance. 6 , 20 Unlike other studies, 5 , 6 we did not demonstrate an association between systolic BP and PAD or a protective association between HDL and PAD, but this might have been due to the sample size not being large enough.
The results reached statistical significance on years 3 and 4, and they were of borderline significance for years 1 and 2.
Moreover, a correlation of borderline significance was found between cRAGE and patient exhaustion. 3.5.
0.8±1.4%, p=0.08) of borderline significance at the tibia in the BS compared to no change in LI arm.
Age at diagnosis was a significant factor in HER2 and TN subtypes though of borderline significance in the Luminal B subtype.
An excess of borderline significance was found among mothers of children with CNS tumours (O 32, SIR 1.2, 95%CI 0.9–1.8).
The mean number of calcifications was higher in the study group than in the control group, but the difference was of borderline significance.
Similarly, the Danish study indicated an association of borderline significance between maternal mobile phone use during pregnancy and hearing loss in children at age 7 years, but the authors were cautious about drawing inference due to potential biases. 37 A large Danish cohort study reported 10–20% higher rates of hospitalizations and outpatient visits for migraine among mobile phone subscribers, especially those with a recent subscription. 13 This result was difficult to interpret and may reflect reverse causation, i.e. people with migraine being more likely to use a mobile phone.
Two of these concerned early vocabulary and word combination scores and were of borderline significance at the traditional 5% level.
In consequence, the association between increased confidence and previous Indigenous experience was no longer statistically significant (aRR 0.86, 95% CI 0.73–1.01), and the association between the outcome and rural Australian origin was of borderline significance (aRR 0.83, 95% CI 0.68–1.00).
ACCORD showed a 42% increase in risk of macrovascular complications, but this was of borderline significance, possibly due to the smaller sample.
Results showed that the effect of telmisartan on the primary outcome was of borderline significance, probably because of an unexpectedly lower number of outcome events [5] .
The association for women remained significant or of borderline significance with further adjustment for quintile ∑PCBs or quintile DDE.
Comparing highest versus lowest HbA 1c quartiles and adjusting for age, race, sex, weight, and height, strength was significantly lower (−4.70 ± 2.30 N · m; P value trend = 0.02) and results were unchanged after adjustment for physical activity ( P value trend = 0.045) but of borderline significance after additional adjustment for peripheral neuropathy ( P value trend = 0.05).
While the increase was of borderline significance, it suggests the CPI’s potential for more equitable park use between sexes.
While late-life EPT posed an increased risk, the estimates were only of borderline significance.
Besides aggressive fluid replacement, AKI was identified as a positive predictor of prolonged hospitalization while male sex was of borderline significance (Table S4, Supplemental Digital Content 1, http://links.lww.com/MPA/B397 ).
Primary Outcome: Pain Intensity Following a 4-week intervention period, all exercise modalities demonstrated varying degrees of pain intensity reduction in comparison to the control group, with three of them showing statistically significant reductions, and one exhibiting an effect of borderline significance.
The association with birth weight disappeared after adjustment for birth length and head circumference, while the association with birth length persisted, and remained of borderline significance, after adjustment for birth weight and head circumference.
9.45 ± 6.2 ng/mL; p = 0.046) were elevated in the plaque group, although the difference in BMP-2 was of borderline significance ( Table 2 ).
Although our findings are of borderline significance, and our study is small, they are plausible and consistent with numerous experimental data and require corroboration.
At multivariable analysis, obstructive jaundice was also significantly associated with the presence or development of DM during follow-up (HR = 4.92; 95% CI 1.75–13.9), while the association with smoking and blue-collar professions remain only of borderline significance.