Factors entered in the MVA were significant or of borderline significance in univariate analysis.
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“of borderline significance”
In the literature
In the first years of the period considered, a positive association between PAC and abortion emerged, although of borderline significance due to the small number of cases; the PR was 1.08 (95%CI: 0.92–1.26) in 2010–2012, 1.21 (95%CI: 1.03–1.42) in 2013–2015 and 1.17 (95%CI: 0.98–1.40) in 2016–2018.
Patients with pT1 stage tumors (HR: 2.04, p -value = 0.0159) and high-grade tumors, according to the 1973 WHO classification (HR: 1.83, p -value = 0.0522), had a higher risk of recurrence, although the latter association was of borderline significance.
The work‐related difference in annual decline in FEV1 was more pronounced in current smokers than never smokers although this difference was only of borderline significance.
Additionally, the prevalence of disc herniations increased significantly among the controls and had an increasing trend of borderline significance among pilots.
This finding was of borderline significance due to stopping recruitment early but is consistent with the results of large-scale, published meta-analyses. 9 , 17 MiECC improved a visual analogue quality-of-life measure.
Increasing folate intake reduced plasma homocysteine levels and induced an increase in total antioxidant capacity that was of borderline significance.
Morbidity in the exposed cohort in relation to the unexposed cohort (external analysis) In the external analysis ( table 2 ), we observed a very small increase of borderline significance in all-disease risk among Chernobyl cleanup workers (RR=1.01; 95% CI 1.00 to 1.03).
Only HIV-1 infection and HR-HPV types were statistically significantly associated with HSIL in univariate analysis ( Table 3 ), while low CD4 cell count (<200 cells μ l −1 ) had an association of borderline significance.
The analysis of exposure to combinations of oxygenated solvents (Table 5 ) showed that men exposed to ketones, alcohols and tetrahydrofuran had a significantly higher risk of hypopharyngeal cancer (OR = 2.79; 95% CI [1.12–6.95]); an increased OR of borderline significance was also observed for laryngeal cancer (OR = 2.25; 95% CI [0.94–5.38]).
In a follow-up study of the preterm infants randomised to breast milk or pre-term formula, differences in total cholesterol between the groups at age 13–16 years were of borderline significance [ 65 ], but there were differences in other lipoproteins, including a lower ratio of LDL to HDL cholesterol in the breast milk group. 3.5.2.
After adjustment for maternal smoking, BMI, and paternal depression preceding the maternal depression (model 2), the risk of very preterm birth was of borderline significance (OR 1.23, 95% CI 0.97–1.56), and the risk of moderately preterm birth was unaltered (OR 1.34, 95% CI 1.22–1.46).
In men, apart from high HDL-C levels, low physical activity, and non-HDL-C levels of borderline significance, all variables were related to CHD mortality.
Further, significantly lower odds of vaccine acceptance were found in the 5th (aOR: 0.10; 95% CI: 0.04–0.24) and 4th (aOR: 0.34; 95% CI: 0.16–0.74) wealth index quintile, and lower odds of borderline significance were found in the 2nd (aOR: 0.49, 95% CI: 0.23–1.04) wealth index quintile when compared to the 1st quintile, i.e. the poorest households.
None of the attitudinal or belief scales were significantly associated with test selected, although the fatalism and gender-equity scales were of borderline significance.
38 39 On the other hand, the subgroup analysis is based on a comparison between trials; it is not robust across statistical analyses (the effect did not appear in the univariable analysis but only in the meta-regression, and the meta-regression is at high risk of over-fitting—six trials account for 92.5% of the weight), and was not prespecified; the apparent reduction in mortality with GLP-1 is both small and of borderline significance.
In contrast, the divergence between species does not significantly differ between NEX and ENDEX genes in the BA46 data set, although the human–chimpanzee difference is of borderline significance ( P human–chimpanzee BA46 = 0.06; P human–rhesus BA46 = 0.63; P chimpanzee–rhesus BA46 = 0.84).
All the adjusted HRs above were accounted for smoking-alcohol interaction Significant trends suggesting increased risk with daily smoking amount (p for trend = 0.01) and cumulative consumption (pack-years) (p for trend = 0.01) were observed in the adjusted HRs of Model 1, but the trend was of borderline significance for smoking duration (p for trend = 0.06) (Table 2 , Model 1).
Adding deprivation to this model (model G) did not significantly improve the fit, although the test for trend was of borderline significance.
The SNPs most strongly associated with either systolic or diastolic BP were of borderline significance and none have been reported as associated with BP in previous BP GWASs.
GDF15 was of borderline significance.
After the 2nd dose, there was again a trend to lower rates in men of fatigue (RR 0.78, p = 0.07), headache (RR 0.71, p = 0.052) and myalgia (0.68, p = 0.054), although these differences were of borderline significance.
Gamba et al 26 note the highest proportion of significant findings in the expected direction among studies examining presence of food stores (vs proximity or density), the approach we have used; however, significant findings were noted to be commonly quite small and of borderline significance.
Our previous controlled evaluation of the intervention found statistically significant reductions in demand for CT scans and full blood counts, a reduction in demand for urea and electrolytes of borderline significance, and no change in demand for liver function tests [ 22 , 23 ].
The differences in survival are statistically significant for overall survival, but they are of borderline significance for relapse-free survival. 4.