“showed a trend”

At steady state after twice-daily administration, C max increased dose proportionally over the entire dose range while the exposure in terms of AUC showed a trend to increase more than dose proportionally (Table 3 ).

The Erk2 +/– heterozygous mice did show significant reductions in fractional shortening after TAC compared with wildtype mice and Erk1 –/– mice showed a trend toward reduced function, showing that while ERK1/2 activity may not be necessary for concentric hypertrophy, it does play a role in the process.

PKCδ-deficient monocytes showed a trend towards decreased CCR2 expression, which remained unaltered after TsSP treatment (Fig. 7b ).

The study showed a trend towards disease stabilization for the treatment group on the GDS ( Reisberg et al., 1982 ) on the MMSE and on the functional assessment staging measure (FAST; Reisberg, 1988 ).

In the first case (>45% recovery) statistical analysis showed a trend towards lower values of total cholesterol (p 0,0584) in patients showing recovery.

A small study conducted at the University of Minnesota [ 20 ] showed a trend toward an improved outcome in patients treated with imatinib during the pre- and posttransplantation periods.

Three of the four studies reported significantly less estimated blood loss in the LESS group, and two studies showed a trend towards shorter hospital stays for LESS patients.

Although not statistically significant, patients with moderate and high myopia patients also showed a trend towards less doctor-shopping behaviors.

Although numbers were small, intravenous corticosteroid use (eg, at enrolment 52 patients treated with intravenous corticosteroids, 28 of whom received ≥3 ‘pulses’) also showed a trend towards being associated with MetS (OR 1.60, 95% CI 0.87 to 2.97).

Although the 1.0 mg dose showed a trend towards a therapeutic effect for induction of clinical remission, the results were less robust than those observed with the 0.5 mg dose.

Lumbar Overall, the 23 patients who received lumbar surgery showed a trend toward decreased DRT.

The AMDase mutants M159V and P14V/P15G both showed a trend towards lower K m values, with the entire set of malonate substrates tested, compared with the K m values observed with the wild-type AMDase.

In a phase II study ( NCT00773890 ), an oral P-selectin blocker used chronically lowered plasma sVCAM and showed a trend toward improving microvascular flow [ 107 ].

innocua showed a trend toward an increasing effect with increasing isoeugenol concentration in both assays, but the effect was not statistically significant at 1⁄2 × MIC (Figure 4 ).

Although RT3DE showed a trend toward underestimating LA volume, it correlated strongly with CT measurements.

Of 22 pairwise comparisons from interrupted time series, 18 showed stepwise increases in compliance with hand hygiene, and all but four showed a trend for increasing compliance after the intervention.

Brief Pain inventory (BPI) Results of the BPI showed a trend in the reported reduction of mean pain severity from 5.0 (ten-point scale) to 3.7 [-1.20 (95 % CI: -1.66 to -0.75)], and these scores were maintained at three months [-1.12 (95 % CI: -1.65 to -0.58)] (see Fig. 2 and Table 1 ).

The iP content in the leaves showed a trend similar to that in the petioles, whereas ZT was maintained at a relatively stable level during carrot growth.

Comparison of this data showed a trend towards a higher success rate when using SCID mice, compared to the use of nude mice either for the F1 generation (28.2% vs. 19.3%) or for the final successful establishment (16.9% vs. 13.6%), although these differences were not statistically significant.

Other clinical trials in the context of graft-versus-host disease (GVHD) or hematopoietic stem cell transplantation (HSCT) also showed a trend to more infections after MSC therapy.

Compared to controls, non-activated and CD3+CD28-activated CD4 + T cells from patients showed a trend toward reduced respiration and glycolysis ( Figure 1 Ci), and the increase in OCR and ECAR levels upon CD3+CD46 activation—which was present in all HDs—was absent in CD46-deficient individuals ( Figure 1 Ci).

Analysis of this dataset alone showed a trend towards an effect of age on the rise in Aβ levels in the first 6 hours.

However, when computing coherence across all trials and comparing the decision stage with baseline, we found a very similar pattern of results (with P2, P3, and P6 showing a significant enhancement of low-frequency coherence during the decision stage; P4 showed a trend for significance of 0.031).

In accordance with the AXIOM trial, the majority of trials with IM IFNb-1a showed a trend towards better quality of life, particularly in the physical domains, or at least a stable quality of life [ 19 , 20 , 21 ].

Mutations of STAG2 and TP53 showed a trend for co-occurrence with a synergistic negative effect on prognosis when both mutations were present.