“showed a trend”

In randomised phase III trials in advanced gastric cancer, FP led to improved response rates compared with 5-FU, doxorubicin and mitomycin (FAM) or 5-FU single-agent therapy ( Kim et al , 1993 ), and showed a trend towards improved response rates compared with 5-FU, doxorubicin and methotrexate (FAMTX) or etoposide, leucovorin and bolus 5-FU (ELF) ( Vanhoefer et al , 2000 ).

The results showed a trend to higher 5-FU dose for younger patients in treatment arms 1 and 2, where no IFN was applied.

No losses were identified, although one carci- noma showed a trend towards loss of chromosome 18.

The symptoms reported were similar, except for nausea and vomiting which showed a trend towards lesser severity in A, and overall condition which was rated higher in A, particularly following the second and subsequent cycles (Table 4).

Two studies mentioned that p27 was strongly reduced in endometrial carcinoma ( Ahn et al , 1998 ; Bamberger et al , 1999 ), whereas a recent study showed a trend of increased p27 protein staining with high grade endometrial carcinoma ( Nycum et al , 2001 ). p27 expression in endometrial carcinoma still remains contradictory.

Pregnant women showed a trend for increased high-risk human papilloma virus clearance during the third trimester and postpartum compared to non-pregnant women (hazard ratios 3.3 (0.8–13.7) and 4.6 (1.6–12.8), respectively).

Antigen treated patients showed a trend toward suppression of IL6 and GMCSF production; there was a higher level of spontane- ous cytokine present in the absence of antigen than when antigen was added in vitro.

Furthermore, these markers showed a trend for correlation with clinical conditions.

Although 10 day ethanol treatment groups showed a trend to lower body weights, body weight was not significantly different from controls.

Several of the compounds that are released naturally from lima bean showed a trend towards an increase in EFN secretion, although the difference was not significant: EFN secretion in response to Linalool was on average higher by 40% than in control plants, and DMNT ((3 E )-4,8-dimethylnona-1,3,7-triene) increased EFN secretion by 50% (see Table 1 in Kost and Heil 2006 ).

Both showed a trend toward a higher incidence for the internal medicine patients.

In a randomized study of 192 patients, Svendsen et al (1995) also showed a trend to improved survival in Dukes C patients.

While the present study showed a trend toward higher in-patient costs for de Gramont (other than to receive chemotherapy) these differences did not reach statistical significance (de Gramont vs Lokich, mean difference=£874, P =0.181, de Gramont vs raltitrexed, mean difference=£828, P =0.206), although this must be considered in the light of the small sample size.

However, low microvessel density showed a trend towards better response rate in the docetaxel arm (RR 68% vs 40%, Table 2 ).

The progression free survival (PFS) and the overall survival (OS) showed a trend in favor of arm A, but did not meet the statistical significance.

The MVP regimen showed a trend towards a higher response rate than the other regimens in certain trials with no benefit on survival ( Ruckdeschel et al , 1985 ).

Any degree of uPA–PAI-1 complex accumulation inside the tumour cells showed a trend towards a significant association with nodal metastasis.

The latency to drowsiness decreased significantly after sleep deprivation, and the latency to SWS showed a trend toward a decrease (Fig. 4B ).

Conclusion Generally the results showed a trend of increase in mosquito resistance status with cross-resistance against all the three pyrethroid insecticides.

In contrast, mice that received ATL-801 did not lose body weight and showed a trend towards recovery of their body weight.

Injury significantly decreased nicotinamide adenine dinucleotide phosphate staining and FK1706 treatment showed a trend toward increased staining [ 81 , 82 ]. 5.3.

Interestingly, garlic-only intervention arms of reviewed studies which were not suitable for meta-analysis also showed a trend for greater reduction in BP with higher starting BP.

More importantly, the TORCH study also supported the safety of LABAs in individuals with COPD, and showed a trend towards increased survival for patients treated with salmeterol alone compared with placebo (hazard ratio 0.879, 95% CI 0.729–1.061) and no increase in adverse events ( 93 ).

In the first experiment, tadpoles with resistant haplotypes ( f and j ), but not those with a susceptible haplotype ( g ), showed a trend of reduced growth when exposed to the pathogen, which suggests a possible tradeoff between growth and immune function.

When subjects with metabolic syndrome and with diabetes were compared with those without diabetes, those with diabetes showed a trend toward a lower prevalence of abnormal HDL (50.1% vs. 62.8% in those subjects with metabolic syndrome without diabetes) and triglycerides (59.3% vs. 65.9%).