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“showed a trend”

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In the literature

2-4 In addition, a randomized trial of sarilumab, another interleukin-6 receptor monoclonal antibody, showed a trend toward lower mortality among critically ill patients. 6 Two randomized, open-label trials exploring the use of tocilizumab in patients receiving supplemental oxygen without noninvasive or invasive mechanical ventilation were recently published. 8 , 9 In one, tocilizumab treatment appeared to reduce the need for mechanical or noninvasive ventilation or death by day 14. 8 It should be noted that dexamethasone was used more frequently in the control group than in the tocilizumab group, which may have mitigated the treatment effect.
32–34 Two pilot trials, not powered for clinical endpoints, showed a trend of more delirium, ventilation time and lengths of stay associated with early deep sedation. 35 36 To collate the literature regarding early sedation and its potential impact on outcome, our research group conducted a comprehensive systematic review and meta-analysis, which demonstrated that early light sedation, compared with deep sedation, was associated with: (1) lower mortality; (2) less delirium; and (3) fewer ventilator days. 37 The ED could be a high-yield clinical arena in which to target sedation depth to improve outcome.
20 In a Duchenne muscular dystrophy study, the primary endpoint of safety was met, and the study showed a trend for maintenance of the 6 min walk test, lean body mass, and bone mineral density versus placebo without reaching statistical significance. 21 Atara Biotherapeutics PINTA745 showed good efficacy in a stroke mouse model, in which it attenuated loss of body weight and improved body weight recovery after cerebral ischaemia.
Blocking myostatin: muscle mass equals muscle strength?
J Cachexia Sarcopenia Muscle · 2020 · PMC7749583