Barely Significant
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“showed a trend”

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In the literature

Results showed a trend towards increased tumoral immune activity and increased peripheral blood cytokine/chemokines levels in a cavrotolimod dose-dependent manner [87].” This was removed: “Of four subjects with MCC, a difficult cancer to treat, two patients had sustained reduction in tumor size 12 to 24 weeks after starting therapy [89].
Concerning satisfaction with life scale and perceived stress levels ( Figures 2A,B , respectively), no significant intra- and inter-group differences were observed ( p > 0.05); however, the exercise group showed a trend to increase their life satisfaction (exercise group, Δ = 1.56 points (95% CI -0.52, 3.63) vs. control group, Δ = −0.17 points (95% CI -1.76, 1.43)) and to decrease their perceived stress levels (exercise group, Δ = −3.67 points (95% CI -6.97, −0.364) vs. control group, Δ = 0.94 points (95% CI -2.57, 4.45)) after the 16-weeks of intervention.
14 Similarly, a prior Mayo Clinic study documented new cytogenetic abnormalities in 25% of patients with PV and change in karyotype from “normal” to “abnormal”, in the absence of overt disease transformation, showed a trend for adverse survival. 15 Collectively, these findings strengthen the argument for conducting karyotypic analysis at the time of diagnosis but also underscore the case for follow-up reassessment of karyotype to ensure continued surveillance.