Barely Significant
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showed a trend

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showed a trendP = 0.0501.0× alpha
Overall, the results did not reveal statistically significant associations in any of the tested models, with the marginal exception of SNP rs743572 ( CYP17A1 ) under the dominant model, which showed a trend toward association (OR = 1.56; 95% CI: 1.00–2.45; P = 0.050), despite moderate heterogeneity ( I 2 = 55.6%).
showed a trendp > 0.051.0× alpha
At the beginning of the trial, males showed a trend toward choosing the EO-treated arm, although no statistical differences were found (χ 2 = 2.46; p > 0.05), whereas females showed a preference for the EO-treated arm (χ 2 = 4.17; p = 0.04) ( Table 2 ), but no significant differences were observed at the end of the trial (χ 2 =3.11; p > 0.05).