“showed a trend”

Furthermore, patients with only a single metastatic site showed a trend toward improved overall survival in comparison to those with multiple metastatic sites (19.0 vs. 13.5 months), while this difference did not reach statistical significance ( p = 0.119) ( Figure 3 D).

Proline and cysteine showed a trend of first increasing and then decreasing, and first decreasing and then increasing, respectively.

An exploratory post hoc analysis of the phase 3 PENELOPE-B trial showed a trend in improved survival and invasive disease-free survival with palbociclib at 6 years in the subgroup of patients with lobular breast cancer [ 126 ].

PME treatment at all doses showed a trend toward reducing pro-inflammatory cytokine levels.

By week 12, both FMT groups showed a trend toward increased IL-10 levels, which may reflect a host adaptive response to ongoing tumor progression.

Results : In BLM mice, pulmonary [ 68 Ga]Ga-DATA 5m .SA.FAPi uptake showed a trend toward increase as early as 5 weeks of treatment compared with the controls, which was confirmed by ex vivo analysis (BLM: 3.31 ± 0.29%ID/g, n = 5; control: 1.61 ± 0.29%ID/g, n = 4; p = 0.0035).

RN7IN6 showed a trend for increasing EE% with loading concentration, with values increasing from 10.3% to 17.8% ( Figure 4 a); however, this trend was not statistically significant.

In terms of response magnitude, the DENV1-4 CD8 MP showed a trend of concentration-dependent IFN-γ production ( Figure 1 B).

Interestingly, from days 8 to 14 p.i., infected animals showed a trend of having lower platelet counts than control mice, with a significant difference observed on day 8.

In the fully adjusted model, high adherence to the DASH diet showed a trend toward better BP control, although the association did not reach conventional statistical significance ( Table 4 ).

A randomized controlled trial showed that the average phototherapy time required by infants receiving AP-32 was approximately 7 h less than that of the placebo group, and the CP-9 group also showed a trend of shortened treatment time ( Tsai et al., 2025 ).

Although not significantly increased overall, IL-6 levels showed a trend toward being higher in the group of COVID-19 patients with neurological symptoms compared to those without symptoms and controls.

However, while most regimens showed a trend toward OS benefit, none reached statistical significance compared to VRd ( Supplementary Figures S8 and S9 ), indicating that longer-term follow-up data are required to confirm their definitive impact on OS.

Age and polypharmacy did not reach statistical significance but showed a trend toward association with the outcome.

Notably, following GNH administration, the expression levels of these differential metabolites showed a trend of reverting towards the normal state of the CON group.

Patients with elevated baseline CRP (>ULN) and IL-6 (>LLOQ) showed a trend toward more pronounced treatment response—a finding potentially attributable to higher IL-6 activity and greater pathogenic significance of this cytokine in these patients.

In this standalone setting, the VMN, with its higher aerosol output rate and superior aerosol characteristics (lower MMAD and higher FPF), as also reported in the literature [ 27 , 28 , 29 ], showed a trend toward slightly higher drug delivery compared to the JN, although this difference did not reach statistical significance ( p = 0.309).

This variability may be attributed to environmental fluctuations during sampling period, which may have limited the detection of statistical differences, although SiKe generally showed a trend toward positive responses.

Significant group × time interactions were found for cortisol in females and cortisone in males, while amylase showed a trend toward interaction in females.

By the 18th month, the Empirical group showed a trend toward improvement in SBP (27.90% vs. 13.63%), DBP (58.13% vs. 45.45%), and MAP target achievement rates (41.86% vs. 31.81%), though the differences were not statistically significant and were accompanied by considerable blood pressure fluctuations.

Near endpoint, mice receiving CAR-T cells showed a trend towards lower tumor volume compared to the naïve T cell group, without changes in body weight between treatment groups ( Figure 4 D-E ).

The weak binding from SLO Q476N showed a trend to further reduction after HPCD treatment in WT and spt2 − /+SPT ( Figure 4 ).

Only TJP1 showed a trend towards interaction with miR-146a-3p, however, there was again a large variation in binding levels among donors (Fig. 4 D).

Influence of Different Motion Speeds on Depth Perception The results of Experiment 1 showed a trend where relatively high motion speeds (10.0 and 15.0 arcmin/s) tended to promote greater perceived depth compared to the static condition, whereas low speed (5.0 arcmin/s) tended to inhibit it.

The studies analyzed showed a trend towards the use of active and experiential strategies focused on key competencies such as empathy, active listening, and nonverbal communication.