Barely Significant
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showed a trend

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showed a trendp = 0.0501.0× alpha
Almost reaching significance was the presence of PETs other than gastrinomas in patients with an MEN1-related death (47% vs 33%, p = 0.058), whereas thyroid disease showed a trend toward higher occurrence in patients with a non-MEN1-related death (0 vs 2.95%, p = 0.050).
showed a trendp > 0.051.0× alpha
At the beginning of the trial, males showed a trend toward choosing the EO-treated arm, although no statistical differences were found (χ 2 = 2.46; p > 0.05), whereas females showed a preference for the EO-treated arm (χ 2 = 4.17; p = 0.04) ( Table 2 ), but no significant differences were observed at the end of the trial (χ 2 =3.11; p > 0.05).
showed a trendp > 0.051.0× alpha
In addition, we evaluated changes for genes NefH and Ngf, also involved in axonal function, growth, maintenance and neuron survival ( Ryden et al., 1997 ; Hayakawa et al., 2012 ; Turney et al., 2016 ; Fornaro et al., 2020 ) although changes between vehicle and boldine SCI samples were not significant and only showed a trend ( Supplementary Figures 9G, H ; p > 0.05).
Later age of symptom onset (70+ years) was associated with lower odds of genetic testing completion (OR 0.23; 95% CI 0.12–0.43; P < 0.001) compared to the reference group (10–19 years), while early symptom onset (0–9 years) showed a trend toward higher odds of genetic testing completion that approached but did not reach statistical significance (OR 1.53; 95% CI 1–2.37; P = 0.05).