Acute latrepirdine administration was associated with modest improvements in the performance of a delayed matching to sample task in young adult and aged monkeys and showed a trend towards attenuation of scopolamine-induced impairments in young adult monkeys. 48 Recent studies have provided further insight into the potential mechanisms of action that may underlie latrepirdine's cognitive-enhancing properties.
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55 After 4 weeks of treatment, obese mice receiving the nonapeptide showed a trend toward lower body weight (being around 10% lighter than controls) and weight gain was significantly reduced, to around 20% of that observed in control mice.
The frequency of the APOE ε4 allele in the SCI group showed a trend toward being an intermediate level between the AD/MCI and healthy control groups (SCI: 14.7%, AD: 23.6%, MCI: 21.4%, and controls: 7.3%).
4 ) though miR-21 showed a trend of increasing with the emergency of atherosclerosis.
In MCF7-AROM1 xenografts, letrozole plus everolimus showed a trend toward enhanced tumor regression, versus the single agents.
As far as TIC signatures are concerned, GSEA comparison of the HIS with three published TIC signatures [ 36 , 84 , 85 ] showed a trend for anti-correlation between our signature and the tumor-initiating gene profile (that is, genes that are upregulated in TICs are significantly enriched in the downregulated genes of the HIS, whereas genes that are downregulated in TICs are significantly enriched in the upregulated genes of the HIS (see Additional File 9 )).
Soluble vascular endothelial growth factor receptor-1 by quartile of baseline selenium status Given the significant effect of Se treatment on sFlt-1 concentration in women in the lowest quartile of Se status at baseline, we decided to determine whether the effect showed a trend by quartile.
Of particular interest was the observation that non- HpaII CpG dinucleotides flanking this HELP-seq tagged HpaII site also showed a trend of hypomethylation (from 90.4% to 34.4%).
AD cases showed a trend for elevated expression levels of PRGN when compared with the levels in non-AD cases, but the difference did not reach statistical significance ( P = 0.5304) (Figure 6 Ba,D).
Moreover, CsA showed a trend to decreased glomerular filtration rate (GFR).
Enriched cbMSCs showed a trend toward higher expression of HLA-ABC and lower expression of CD34 and CD133.
HPAI-H5N1 virus infected ferrets showed a trend toward prolonged APTT on 3 dpi with a mean of 28 (17.1-38.9) seconds and on 4 dpi 26.3 (17.3-25.3) seconds, which was statistically significant when compared to all APTT results in pre inoculation samples (3 dpi p = 0.02, 4 dpi p = 0.02) .
ORR was comparable between patients with standard and high-risk profile, the subgroups (25.8% versus 24.6%), while time-to-event endpoints showed a trend of shorter duration in high-risk patients, including median duration of response (5.6 months versus 8.3 months) and overall survival (9.3 versus 19.0 months).
But for potassium leves, participants on Tenofovir (TDF)-based therapy showed a trend of lower levels of biochemical parameters compared to those on Efavirenz (EFV) and Nevirapine (NVP)-based antiretroviral regimens.
Our results showed a trend toward these statements since a reduction in the abundance of taxa with oligotrophic characteristics, such as Verrucomicrobia [34] , and Planctomycetes [58] were detected in cultivated fertilized soils.
We found no significant association between cord blood 25(OH)-Vitamin D level and subsequent development of allergic sensitization or allergic rhinitis although the effect estimates showed a trend of decreased risk of allergic outcomes by deficient Vitamin D levels which has also been suggested by others [37] .
In situ hybridization data showed a trend: hsa-miR-21 levels were the lowest in normal tissue, and increasingly higher in adenocarcinoma and metastasis, meanwhile, a similar expression was observed in cancer cells nodes and liver recurrences, suggesting that hsa-miR-21 upregulation could predict an advanced metastatic disease.
The lenticular reduced glutathione also showed a trend toward normalization in these groups.
Several parameters, including lower gestational age, maximum temperature, low alkaline phosphatase, low serum bicarbonate and high Acute Physiology and Chronic Health Evaluation II showed a trend towards association with fetal mortality, but not reaching statistical significance.
In fact, 5 years after primary vaccination with 2- or 3-component aP vaccines, the children immunized with the 3-component vaccine showed a trend to a longer persistence of anti-PT IgG after the preschool boost compared with the recipients of the 2-component vaccine ( 18 ).
These probiotics resulted in significant improvement of infection or showed a trend in that direction.
Low admission phosphate showed a trend, but was not significantly associated with low iCa ( P = 0.052; Table 4 ).
In this study, including 83 intubated patients undergoing continuous subglottic secretion drainage (SSD), the authors found that patients with persistent intra-cuff pressures below 20 cm H 2 O showed a trend towards a higher risk of VAP (relative risk (RR) = 2.57, 95% CI = 0.78, 8.03), and a statistically significant risk of VAP among patients not receiving antibiotics (RR = 4.23, 95% CI = 1.12, 15.92).
We observed that tumors expressing TBX2 showed an increased tendency towards metastasis while CST6 expressing tumors showed a trend towards a decrease in metastatic potential.
Secondarily, we found that the children in the treatment group scored as needing significantly less caregiver assistance during self-care and social activities and showed a trend toward higher skills in these areas.