Barely Significant
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“showed a trend”

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In the literature

29 , 30 , 32 , 34 , 38 , 41 Three did not detect a significant change – one showed a trend towards increase insulin resistance but failed to reach statistical significance, 55 another had a sample size of only six participants 27 and the remaining study did not measure body composition changes so it is unclear whether changes to this occurred. 39 All but one study 55 was prospective longitudinal in design but none had a control group.
According to the analysis of amplitude variation curve, the amplitude of Group B signals also showed a trend of gradual decrease with the increase of cycle number, and the amplitude with a dominant frequency of 88 kHz decreased most significantly in the 400–500 cycles; the amplitude with a dominant frequency of 60 kHz decreased significantly in the 10–100 cycles, and the amplitude decreased slowly in the 100–600 cycles.
In a large prospective study (EPIC-Norfolk) evaluating the risk of CAD in association with the Val34Leu variant and fibrinogen levels, it was found that Val34Leu homozygotes in the lowest tertile of fibrinogen concentration had increased risk of CAD, whereas individuals in the highest tertile showed a trend towards reduced risk of CAD [ 122 ].
111 Similarly, another randomized placebo-controlled trial with NASH patients with F1-F3 fibrosis with emricasan (5 mg or 50 mg) for 72 weeks did not improve liver histology in patients with NASH fibrosis and showed a trend towards worsening of fibrosis and ballooning. 112 This drug is unlikely to hold promise.