In the subgroup analysis, former-smoker (HR 0.481) and patients with Ex19del (HR 0.622) showed a trend toward a not significant increase of PFS in favour of the combination arm, as previously observed in other similar studies ( 56 ).
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It showed a trend of better efficacy with methylprednisolone (MP) and intravenous (IV) treatment but no significant difference between the short (five days) or long (15 days) duration of therapy [ 47 ].
SA- β -gal staining of ovarian sections showed a trend consistent with that of the in vitro experiments.
However, T + 3-MA group showed a trend opposite to that of TEAS group, but the difference was not statistically significant ( Figure 3(a) , 3(b) ) (compared with Sham group, ∗∗∗ P < 0.001; compared with Model group, # P < 0.05). 3.6.
The organic carbon content, total nitrogen, total carbon, available phosphorus, moisture content of the soil samples showed a trend of first increasing and then decreasing with the increase of altitude.
Bifidobacterium showed a trend of decrease in our study worth to discuss.
Only the RNFLD angle slope showed a trend toward a significant correlation with the visual field slope, and this did not differ with glaucoma stage ( Fig. 3 , Table 3 ).
Intriguingly, the Atm-Null MEFs showed a trend towards increased nuclear envelope rupture inside the small constrictions ( Figure 5H ), consistent with previous findings in lamin A/C-deficient cells ( Denais et al., 2016 ; Raab et al., 2016 ), although this trend did not reach statistical significance ( p = 0.11).
In our study, ALC values showed a trend to recover 6 months after the end of RT in the hypoF group but not in the standard group, in which the number of Grade 1 leukopenias was significantly higher at this time point.
The increase in AF incidence is accompanied by an increase of risk factors and comorbidities related to AF while the burden of coronary artery disease and heart failure showed a trend towards reductions over time.
Pain Pain intensity showed a trend towards lower values in the thermal hyperalgesia compared with the sensory loss phenotype, but these results were not consistent across questionnaires addressing pain intensities (GCPS, BPI, and subscores [Tables 1 – 3 ]) and can therefore be explained by the lower amount of patients with CPSP in the thermal hyperalgesia phenotype (Table 3 ).
PC786 showed a trend toward reduction of symptom score and mucous weight.
Total polar surface area (TPSA) showed a trend similar to that in other QSAR descriptors.
Furthermore, we found that different types of secretome showed a trend toward a positive effect on cell viability.
Mitochondrial respiration as measured by OCR showed a trend toward reduction after IR as compared to shams.
At T2 and T3 time points, the lid margin irregularity and thickening scores of the upper and lower eyelids of ApoE –/– mice tended to increase compared with WT mice, while the scores in ApoE –/– mice treated with IPL irradiation showed a trend of decrease, although the difference was not statistically significant ( Figures 1E–H ).
The microstate D of group I showed a trend of increasing from top to bottom before treatment, and it could be observed that the process of increasing microstate D gradually slowed down in the course of the treatment, showing a trend of increasing standard microstate D from top to middle.
For the MAL, both groups showed a trend toward greater improvements from baseline.
The geographical distribution of incidence rates in China in 2017 showed a trend of high in the northern regions and low in the southern regions.
While the results of ACNS-0831 intention-to-treat analyses showed a trend in favor of treatment combining radiotherapy and chemotherapy in these patients, preliminary results of “per-protocol” analyses confirmed a significant clinical benefit in favor of treatment combining radiotherapy and chemotherapy for children older than 1 year following complete resection.
There were more differential metabolites in the UUO group and the Sham group, and the differential metabolites showed a trend of decrease in the UUO mice after drug intervention.
Unstimulated neurons expressing mGFP PICK1 and mCherry PICK1 showed a trend toward a shorter mGFP fluorescence lifetime compared to controls, which did not reach statistical significance, suggesting weak FRET between mGFP and mCherry in the PICK1 dimer under basal conditions.
In the NCI group, total cPLA2 did not significantly differ between the APOE3/E3 and APOE3/E4 carriers, while the phosphorylated cPLA2 level showed a trend increase in APOE3/E4 carriers as compared to APOE3/E3 carriers (Fig. 4 A).
Unlike the expression of mRNA, the expression of AMPK-ɑ and pAMPK-ɑ was also up-regulated when TNF-ɑ, IL-6, MMP1, and MMP3 showed a trend of up-regulation ( Figure 6D ).
The first category showed a trend of first rising and then falling, and included (Z)-3-Hexen-1-ol acetate, 3(Z)-Hexenyl butanoate, and(Z)-3-Hexen-1-ol benzoate.