Deciphering the Role of Ferroptosis in the Pathogenesis of Peripheral Artery Disease Myopathy.

Lastly, the inflammation-related gene STAT3 exhibited a negative trend in expression in erastin myotubes, though this trend was not statistically significant ( p = 0.1882; Figure 2 L).

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Comparing the expression of autophagy-related genes, ELAVL1 was significantly downregulated in erastin myotubes ( p = 0.0137; Figure 2 J), which contradicts our findings in CLI patients, whereas BECN1 showed a trend of upregulation that was not statistically significant ( p = 0.2024, Figure 2 K).

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Although HMOX1 did not show a statistically significant change compared to controls ( Figure 3 B), there was a clear trend of increasing HMOX1 expression in CLI patients, as seen in the Western blot results ( Figure 3 A).

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NCOA4 did not show a strong trend in either direction ( Figure 1 E).

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Although the change in HMOX1 protein abundance did not reach statistical significance, the upward trend noted in the muscle from CLI patients ( Figure 3 A) paralleled the changes seen in HMOX1 RNA expression.

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