Prognostic Value of Regnase-1 in High-Grade Soft Tissue Sarcoma: Favourable in UPS, Yet Inverted in Adjuvantly Irradiated Patients.

Cancers (Basel) · 2026 · PMC13162679 · PMID 42122218

Europe PMC DOI

hedged sentences

0.0593

closest p · 1.2× alpha

0.0745

boldest claim

The sentences

a strong trendp = 0.0593so close (0.05 < p ≤ 0.1)

In Cox regression analysis, there was a strong trend toward reduced mortality risk (HR = 0.4, 95% CI = 0.16–1.0; p = 0.0593). 3.3.3.

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showed a trendp = 0.0745so close (0.05 < p ≤ 0.1)

Intratumoural PD-1 status was not associated with OS overall, although PD-1 + AS showed a trend towards poorer survival ( p = 0.0745; Supplementary Figure S4A–D ).

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nominally significantno p-value reported

All results are summarised in Supplementary Table S12 and highlight that some nominally significant findings—particularly in small treatment-defined subgroups—may be imprecise and prone to overestimation. 3.3.7.

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a negative trendno p-value reported

As observed previously, the favourable prognostic effect of Regnase-1 in the total cohort and in surgery-only patients was lost—and shifted towards a negative trend—after adjuvant radiotherapy.

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did not reach statistical significanceno p-value reported

In the UPS subgroup, higher Regnase-1 expression trended toward improved survival (HR = 0.986, 95% CI 0.971–1.001, p = 0.060; n = 31, events = 20), though this did not reach statistical significance.

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