Excerpts

However, a clear trend was observed: patients who were prescribed more than 8 medications during hospitalization were at significantly higher risk of experiencing at least one DDI ( p < 0.01), emphasizing the importance of polypharmacy monitoring as a clinical risk factor.

Densitometric analysis revealed a highly significant delay in colony formation in ITIH5-expressing CCC-5 cells by 38.29 % ( p < 0.01).

They found in a multivariate analysis, laterality becomes highly significant ( p < 0.01) and that right-sided tumors have a worse OS than left-sided tumors (15 vs. 18 months; respectively) [ 39 ].

A highly significant inhibitory effect ( p ≤ 0.01) on viability was observed for 2.5 μM CBD and for 5.0 μM THC and CBD when applied individually.

When stratified by type, there was a decreasing trend for melanoma in both men and women (males: −6.4, p = 0.01; females: −4.3, p = 0.032).

Other factors associated with PFS (or with nearly significant trends) included the number of positive sentinel nodes ( p < 0.01), mitoses ( p = 0.07), primary presentation ( p = 0.06), and BRAF mutation ( p < 0.01), whereas LVI ( p = 0.1) was not associated with PFS. 3.2.3.

Upon analyzing the outcomes of the two approaches, it was found that significant differences exist between them in all 12 cases ( p < 0.05), with some cases showing highly significant differences ( p < 0.01 or p < 0.001).

Cluster 10 consisted of 201 cells from both the Lin− and Lin+ cell populations from each patient, with over 1800 genes that were highly significant ( p value ≤ 0.01) ( File S3 ).

In the AGS cells and AGS-exo, we detected 552 miRNAs, of which 133 miRNAs are statistically significant, 37 miRNAs are highly significant (|log2 (multiple)| >1 and p < 0.01), and 96 miRNAs show significant differences ((|log2 (multiple)| >1 and 0.01 ≤ p < 0.05).

A statistically significant difference was considered when p ≤ 0.05 and highly significant p ≤ 0.01.

The Kruskal–Wallis Test with Bonferroni correction identified nine of our 754 miRNAs tested to correlate significantly with our VEGF expression and for PTEN, we could find 11 miRNAs with this approach ( Table 4 ) which is a highly significant overrepresentation of miRNAs identified ( p <0.01).

Among the genes associated with worse OS, several exhibited a highly significant impact on patients’ OS ( p -value < 0.01).

Statistical differences were defined as significant for * p < 0.05 and highly significant for ** p < 0.01 and *** p < 0.001. 3.

The concentrations were also found to be highly significant ( p < 0.01) in 500 mg/kg BW (P.T) and in 250 mg/kg BW.

The EFS and OS for patients with stage I, II, III, and IV MGCTs showed a decreasing trend, with EFS rates of 95.27%, 93.06%, 73.63%, 70.43% ( p < 0.01) and OS rates of 100%, 93.31%, 87.69%, 84.64% ( p = 0.04), respectively.

The results remained consistent: patients with poor pathological response (ypIIA/IIIA) exhibited significantly higher recurrence risks, and intensified adjuvant IO + Chemo showed a clear trend toward superior EFS ( p = 0.011, Supplementary Figures S1 and S2 ). 3.5.

All four endometrial cell lines demonstrated an enrichment of endometrial cancer heritability in the anchors of promoter-associated loops ( Table 2 ), although the enrichment in Ishikawa loops did not reach statistical significance (Bonferroni threshold, p < 0.0125). 2.3.

We observed an increasing trend in diversity from the HC to CRC ( p = 0.013, compared to HC) ( Figure 2 a).

The Number of CD103+ Lymphocytes Correlates with the Infiltration of CD4+ and CD8+ T-Lymphocytes Correlation analyses indicated a highly significant positive correlation between the densities of intratumoral CD8+ and CD103+ T-lymphocytes (r = 0.380; p = 0.013).

Consistent with earlier findings, LOH3 conferred a worse prognosis ( Figure S2C ) ( p = 2.5 × 10 −5 ), and there was a significant trend with chromosomal 8q gain ( p = 0.013) ( Figure S2D ), as reported previously.

Highly significant differences in the absolute lymphocytes and platelets counts were observed among DTC/−T2DM and DTC/+T2DM patients ( p = 0.015 and p = 0.002).

Moreover, for lymphoid and hematopoietic malignancies, a strong and nearly significant association was observed (HR: 1.72; 95% CI: 1.11–2.67, p = 0.015; Figure 3 ).

Lymphocyte count exhibited a decreasing trend of 20% ( p = 0.015), while neutrophil count, platelet count, and NLR and PLR displayed an opposite trend, with increases of 9%, 11.1%, 19.6%, and 39.1%, respectively ( p = 0.532, p = 0.034, p = 0.009 and p = 0.002, respectively), in the DTC/−T2DM patients following the administration of the recommended dose of 131 I.

Not surprisingly, in the control group, there was a positive trend between the number of Ki67-positive cells and absolute tumor volume in males and females ( p = 0.01727).

The normal-like samples did not stain for GLUT1, HK2, and LDHA, with the differences being significant and near-significant with regard to the LDHA and HK2 expression in the cancer sections (44.9% positivity for LDHA, p = 0.018; 35.5% positivity for HK2, p = 0.050).